Merck
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PHR1748

Supelco

Glacial Acetic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Acetic acid, Glacial acetic acid
Linear Formula:
CH3CO2H
CAS Number:
Molecular Weight:
60.05
Beilstein:
506007
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

Agency

traceable to USP 1005706

vapor density

2.07 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

packaging

ampule of 3x1.5 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.371 (lit.)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

density

1.049 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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General description

Glacial Acetic Acid is a simple monocarboxylic acid, which is devoid of water. Pharmaceutically, it is commonly used as a topical antibiotic that treats infections caused by bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Glacial Acetic Acid may be used as a reference standard for the determination of the analyte in raw materials and pharmaceutical formulations by titrimetry and gas chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2954 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

FlameCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

102.2 °F

Flash Point(C)

39 °C

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Quantitative analysis of volatile fatty acids in aqueous solution by gas chromatography
Mahadevan V and Stenroos L
Analytical Chemistry, 39(13), 1652-1654 (1967)
Glacial Acetic Acid
USP43/NF38: United States Pharmacopei and National Formulary
United States Pharmacopeia/National Formulary, 36(3), 77-77 (2018)
Part 5: Pharmaceutical Manufacturing
Remington: The Science and Practice of Pharmacy, 1083-1083 (2005)
B S Nagoba et al.
Journal of infection and public health, 6(6), 410-415 (2013-09-04)
Pseudomonas aeruginosa is a significant cause of burn wound infections and, skin and soft tissue infections. The antiseptic management is an integral part of the management of wound infections and is essential to control wound infection. Although commonly used, concerns

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