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R2751

Sigma-Aldrich

Ruthenium Red

Technical grade

Synonym(s):
Ammoniated ruthenium oxychloride
Linear Formula:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
CAS Number:
Molecular Weight:
786.35
Colour Index Number:
77800
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

assay

34-39% ruthenium (Ru) basis (ICP)

form

powder

application(s)

hematology: suitable
histology: suitable

solubility

water: 10 mg/mL

εmax

200-750 at 533-534 nm

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]

InChI

1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6

InChI key

ZXYSDUPLHOJIOR-UHFFFAOYSA-H

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General description

Ruthenium Red is a hexavalent polysaccharide stain. It inhibits mitochondrial Ca2+ uniporter. It is a capsaicin antagonist and blocks vanilloid receptor-1 (VR-1)-coupled ion channels.

Application

Ruthenium Red has been used for microscopic characterization of cotton tip morphology. It has also been used as a TRPV2 channel blocker.
Inhibits mitochondrial Ca2+ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Packaging

1, 5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release
Jae Hoon Bae
Biochemical and Biophysical Research Communications, 303 (2003)
Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties*
Carolina Garcia-MArtinez
The Journal of Biological Chemistry (2000)
TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells
Yuan Wang
Oncotarget, 7(32) (2016)
George Goodwin et al.
Neuroscience, 429, 10-22 (2019-12-25)
Radiating pain is a significant feature of chronic musculoskeletal pain conditions such as radiculopathies, repetitive motion disorders and whiplash associated disorders. It is reported to be caused by the development of mechanically-sensitive ectopic receptive fields along intact nociceptor axons at...
Ruthenium red as a capsaicin antagonist.
Amann R and Maggi CA
Life Sciences, 49(12) (1991)

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