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Y0001980

Folic acid for impurity I identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):
Folic acid, PteGlu, Vitamin M, Pteroyl-L-glutamic acid
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
Beilstein:
100781
EC Number:
MDL number:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

Inchi Key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Folic acid, a water-soluble B vitamin, is found in several food products. As it is not generated naturally in the human body, diet is one of the easiest ways to obtain it. It plays a crucial role in the biochemical synthesis and repair of DNA and is used in the management of megaloblastic anemias, neural tube defects such as anencephaly and spina bifida. Pharmaceutical drug forms of folic acid are desirable for supplementing its consumption through the diet.

Application

Folic acid for impurity I identification may be used as a reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Packaging

Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Flow injection chemiluminometric determination of folic acid in pharmaceutical formulations
Al-Warthan.AA
Analytical Sciences, 10(6), 919-922 (1994)
A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests
Matias R, et al.
Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)
Folic acid hydrate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6(9), 5662-5663 (2018)

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