244252

Sigma-Aldrich

Perchloric acid

ACS reagent, 70%

Synonym(s):
PCA
Linear Formula:
HClO4
CAS Number:
Molecular Weight:
100.46
MDL number:
PubChem Substance ID:

Quality Level

grade

ACS reagent

vapor pressure

6.8 mmHg ( 25 °C)

assay

69.0-72.0% (ACS specification)
70%

form

liquid

reaction suitability

reagent type: oxidant

application(s)

toxicology assay: suitable

impurities

≤0.001% N compounds
≤5 ppm Silicate and phosphate (as SIO2)

ign. residue

≤0.003%

color

APHA: ≤10

density

1.664 g/mL at 25 °C

anion traces

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.001%

cation traces

Fe: ≤1 ppm
heavy metals: ≤1 ppm (by ICP)

SMILES string

OCl(=O)(=O)=O

InChI

1S/ClHO4/c2-1(3,4)5/h(H,2,3,4,5)

InChI key

VLTRZXGMWDSKGL-UHFFFAOYSA-N

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General description

Perchloric acid (HClO4), an oxygen acid of chlorine, is strongly acidic in nature. Hydrates of perchloric acid are obtained on its dissolution in water.

Application

Perchloric acid has been used to deactivate chloramine-T during the spectrophotometric determination of collagen content of the rat tibialis anterior (TA) tendons and tendon constructs.

It also may be used in the following studies:
  • Determination of reduced glutathione (GSH) and oxidized glutathione (GSSG) content in liver tissues by high performance liquid chromatography (HPLC).
  • As an oxidizing agent in the estimation of sulfur (S) in plant samples.
  • As a solvent for the dissolution of plutonium.

Packaging

100, 4×100, 500 mL in glass bottle
1, 2.5, 4×2.5 L in glass bottle
poly-coated bottles available: product numbers 244252-2.5L-CB

signalword

Danger

hazcat

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Ox. Liq. 1 - Skin Corr. 1A - STOT RE 2

Target Organs

Thyroid

storage_class_code

5.1A - Strongly oxidizing hazardous materials

WGK Germany

WGK 1

Flash Point F

No data available

Flash Point C

No data available

Certificate of Analysis

Certificate of Origin

Sarah Calve et al.
Journal of applied physiology (Bethesda, Md. : 1985), 108(4), 875-881 (2010-01-30)
Tissue-engineered tendons, derived from an autologous cell source, have the potential to provide an ideal replacement graft that is biologically compatible and has the ability to adapt to the specific mechanical requirements of the in vivo environment. Scaffold-free tendon constructs...
Eagleson M.
Concise Encyclopedia Chemistry, 849-849 (1994)
E Driehuis et al.
PloS one, 15(5), e0231588-e0231588 (2020-05-19)
We have recently established a protocol to grow wildtype human oral mucosa organoids. These three-dimensional structures can be maintained in culture long-term, do not require immortalization, and recapitulate the multilayered composition of the epithelial lining of the oral mucosa. Here...
Sulfur in plant materials by digestion with nitric and perchloric acid.
Blanchar RW, et al.
Soil Science Society of America Journal. Soil Science Society of America, 29(1), 71-72 (1965)
Taro Takami et al.
Cancer research, 67(20), 9844-9851 (2007-10-19)
Hepatocyte growth factor (HGF) has been reported to have both positive and negative effects on carcinogenesis. Here, we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout...

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