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360457

Sigma-Aldrich

Acetonitrile

ACS reagent, ≥99.5%

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Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein:
741857
EC Number:
MDL number:
eCl@ss:
39031501
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

100
200

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

≥99.5%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

impurities

≤0.3% water
≤0.6 μeq/g Titr. base
≤8 μeq/g Titr. acid

evapn. residue

≤0.005%

color

APHA: ≤10

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

format

neat

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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1 of 4

This Item
271004CN34892110086
vibrant-m

360457

Acetonitrile

Essential Grade
vibrant-m

271004

Acetonitrile

-
vibrant-m

CN34892

Acetonitrile

-
vibrant-m

110086

Acetonitrile

-
Quality Level

100, 200

Quality Level

200

Quality Level

-

Quality Level

100

grade

ACS reagent

grade

anhydrous

grade

-

grade

-

expl. lim.

16 %

expl. lim.

16 %

expl. lim.

16 %

expl. lim.

16 %

refractive index

n20/D 1.344 (lit.)

refractive index

n20/D 1.344 (lit.)

refractive index

n20/D 1.344 (lit.)

refractive index

n20/D 1.344 (lit.)

impurities

≤0.3% water, ≤8 μeq/g Titr. acid, ≤0.6 μeq/g Titr. base

impurities

<0.001% water, <0.005% water (100 mL pkg)

impurities

≤0.005% free acid (as CH3COOH), ≤0.02% water (Karl Fischer), ≤1 mg/L non-volatile matter

impurities

-

General description

Acetonitrile (MeCN, ACN) is an aliphatic nitrile that is commonly used as a reaction solvent as well as a chemical intermediate in organic synthesis. In many chromatographic techniques, MeCN is used as a mobile phase solvent due to its low viscosity, high elution strength, and miscibility in water.

Application

Acetonitrile can be used as a solvent in:      
  • The solid-phase peptide synthesis.     
  • The sialylation reactions.      
  • The synthesis of copper nanoparticles by reduction of copper nitrate salt using NaBH4. During the preparation, ACN acts as a protecting solvent, which prevents the oxidation of nanoparticles.      
  • The preparation of diaryl selenides by Cu-catalyzed coupling reaction between aryl iodides and diphenyl diselenide. In this process, ACN also functions as a ligand for the copper catalyst to increase its catalytic activity.

Features and Benefits

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS) ,with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup


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