Merck
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45760

Sigma-Aldrich

Ethyl acetate

puriss. p.a., ACS reagent, ≥99.5% (GC)

Synonym(s):
EtOAc
Linear Formula:
CH3COOC2H5
CAS Number:
Molecular Weight:
88.11
Beilstein:
506104
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

ACS reagent
puriss. p.a.

vapor density

3 (20 °C, vs air)

vapor pressure

73 mmHg ( 20 °C)

assay

≥99.5% (GC)

form

liquid

autoignition temp.

801 °F

expl. lim.

2.2-11.5 %, 38 °F

impurities

substances darkened by H2SO4, in accordance
≤0.005% free acid (as CH3COOH)
≤0.05% water
≤0.1% 2-methyl-1-propanol (GC)
≤0.1% ethanol (GC)
≤0.1% methanol (GC)
≤0.1% methyl acetate (GC)

evapn. residue

≤0.001%

refractive index

n20/D 1.3720 (lit.)
n20/D 1.372

bp

76.5-77.5 °C (lit.)

mp

−84 °C (lit.)

density

0.902 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

CCOC(C)=O

InChI

1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3

InChI key

XEKOWRVHYACXOJ-UHFFFAOYSA-N

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Application

Ethyl acetate has been used to compose the eluent mixture for the flash silica gel chromatographic purification of the following compounds:
  • 3-(pyridin-2-yldisulfanyl)propan-1-ol
  • 16-((3-((2-cyanobenzo[d]thiazol-6-yloxy)carbonyloxy)propyl)disulfanyl)hexadecanoic acid
  • (S)-2-(6-((3-((15-carboxypentadecyl)disulfanyl)propoxy)carbonyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
  • (S)-2-(6-((3-((15-carboxypentadecyl)disulfanyl)propoxy)carbonyloxy)-benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
  • methyl 16-((3-((2-cyanobenzo[d]thiazol-6-yloxy)carbonyloxy)propyl)disulfanyl)hexadecanoate
It may be used as solvent for the synthesis of γ-benzyl-L-glutamic acid N-carboxy anhydride (BLG-NCA).

Other Notes

Sales restrictions may apply

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

26.6 °F - closed cup

Flash Point(C)

-3.0 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Andreas F Thünemann et al.
Langmuir : the ACS journal of surfaces and colloids, 22(5), 2351-2357 (2006-02-24)
Superparamagnetic iron oxide particles (SPIO) of maghemite were prepared in aqueous solution and subsequently stabilized with polymers in two layer-by-layer deposition steps. The first layer around the maghemite core is formed by poly(ethylene imine) (PEI), and the second one is
Elena Dubikovskaya et al.
Methods in enzymology, 538, 107-134 (2014-02-18)
The ability of white and brown adipose tissue to efficiently take up long-chain fatty acids is key to their physiological functions in energy storage and thermogenesis, respectively. Several approaches have been taken to determine uptake rates by cultured cells and
Complete oxidation of CO, ethanol, and ethyl acetate over copper oxide supported on titania and ceria modified titania.
Larsson PO and Andersson A.
J. Catal., 179(1), 72-89 (1998)
K H Young et al.
Journal of clinical microbiology, 10(6), 852-853 (1979-12-01)
Ethyl acetate appears to be a satisfactory subsitute solvent for diethyl ether in the Formalin-ether sedimentation technique. In comparative studies, concentration of organisms with ethyl acetate was equal to or greater than that with diethyl ether. No distortion or alteration
Flavio G Rocha et al.
Biomaterials, 29(19), 2884-2890 (2008-04-09)
Our group has previously created a functional neointestine that is capable of restoring absorptive function. However, the endogenous level of vascular endothelial growth factor (VEGF) is markedly reduced in the construct compared to native bowel. Therefore, we wanted to locally

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