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64319

Sigma-Aldrich

L-Methionine

BioUltra, ≥99.5% (NT)

Synonym(s):
(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid
Linear Formula:
CH3SCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
149.21
Beilstein:
1722294
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

biological source

synthetic

product line

BioUltra

assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D +23.7±0.5°, c = 5% in 5 M HCl

impurities

insoluble matter, passes filter test
≤0.5% foreign amino acids

ign. residue

≤0.1%

loss

≤0.1% loss on drying, 20 °C (HV)

color

white

mp

284 °C (dec.) (lit.)

solubility

1 M HCl: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in 1 M HCl

UV absorption

λ: 260 nm Amax: 0.40
λ: 280 nm Amax: 0.05

SMILES string

CSCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Gene Information

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Other Notes

Synthesis of labels for protonation studies by Fourier Transform Infrared Methods for L-glutaric-513C acid; Spacer in isotachophoresis of serum proteins; Essential in culture media for some malignant human cell lines; Growth requirement of various microorganisms

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

T. Hine et al.
Electrophoresis ?83, 541-541 (1984)
W Kreis
Cancer treatment reports, 63(6), 1069-1072 (1979-06-01)
Published reports indicate that normal rodent cells can grow in medium containing either L-methionine or L-homocysteine, whereas malignant rodent cells have an absolute requirement for L-methionine. Our studies with two normal human cell lines (fetal lung fibroblasts and bladder epithelial
CRC Handbook of Microbiology, 4, 1-1 (1974)
W Kreis et al.
Cancer research, 40(3), 634-641 (1980-03-01)
Human embryonic lung fibroblasts (F-136-35-56) capable of growing in medium containing DL-homocysteine instead of L-methionine and human acute lymphoblastic leukemia cells (CCRF-HSB-2) with absolute methionine requirement exhibited dose-dependent growth inhibition when semipurified L-methionine-degrading enzyme (L-methioninase, EC 4.4.1.11) was added to
Bacteriorhodopsin: fourier transform infrared methods for studies of protonation of carboxyl groups.
G Dollinger et al.
Methods in enzymology, 127, 649-662 (1986-01-01)

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