Merck
All Photos(4)

A1260

Sigma-Aldrich

Amantadine hydrochloride

Synonym(s):
NSC 83653, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, 1-Adamantanamine hydrochloride, Tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
Empirical Formula (Hill Notation):
C10H17N · HCl
CAS Number:
Molecular Weight:
187.71
Beilstein:
4198854
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

solubility

H2O: 50 mg/mL
ethanol: soluble

originator

Endo

SMILES string

Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3

InChI

1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;

InChI key

WOLHOYHSEKDWQH-SOVZANNPSA-N

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General description

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Application

Amantadine hydrochloride has been used:
  • to determine its effectiveness in reducing surgery-induced cognitive impairment
  • to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
  • to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
  • to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
  • to determine the pathway of internalization

Packaging

5, 25, 100 g in poly bottle

Biochem/physiol Actions

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.
Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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