Merck
All Photos(2)

A8056

Sigma-Aldrich

3-Amino-1,2,4-triazole

≥95% (TLC)

Synonym(s):
3-AT, 1,2,4-Triazol-3-amine, Amitrol
Empirical Formula (Hill Notation):
C2H4N4
CAS Number:
Molecular Weight:
84.08
Beilstein:
107687
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.83

biological source

synthetic (organic)

assay

≥95% (TLC)

form

powder

potency

30 μM Ki

mp

150-153 °C (lit.)

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Nc1nc[nH]n1

InChI

1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)

InChI key

KLSJWNVTNUYHDU-UHFFFAOYSA-N

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General description

3-Amino-1,2,4-triazole is a herbicide effective against weeds especially bermuda and quack grass. It enters plant circulation through roots and is majorly present in the meristem. 3-Amino-1,2,4-triazole inhibits chlorophyll synthesis resulting in chlorotic leaves and albino plants. In addition, it also affects the growth of the plants. It is exploited to destroy unwanted weeds. It is synthesized from aminoguanidine formate and corresponds to a molecular weight of 84 Da.

Application

3-Amino-1,2,4-triazole has been used:
  • as an organelle-specific perturbant in human embryonic kidney (HEK293T) cells
  • as histidine biosynthesis inhibitor in medium for screening co-transformants from yeast two-hybrid interactions
  • for preservation of midgut sample from honey bee
  • for the determination of tryptophan in proteins.

Packaging

10, 25, 100 g in glass bottle

Pictograms

Health hazardEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 2 - Repr. 2 - STOT RE 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Understanding organellar protein folding capacities and assessing their pharmacological modulation by small molecules
Sharma R, et al.
European Journal of Cell Biology, 97(2), 114-125 (2018)
Thermoanalytical study of the pesticide 3-amino-1, 2, 4-triazole
Sanchez-Soto P, et al.
Journal of Thermal Analysis and Calorimetry, 45(5), 1189-1197 (1995)
Nt-RhoGDI2 regulates Rac/Rop signaling and polar cell growth in tobacco pollen tubes
Klahre U, et al.
The Plant Journal, 46(6), 1018-1031 (2006)
The Biology and Control of Weeds in Sugarcane, 88-88 (2012)
Aarthi Putarjunan et al.
Nature plants, 5(7), 742-754 (2019-06-27)
Cell fate in eukaryotes is controlled by mitogen-activated protein kinases (MAPKs) that translate external cues into cellular responses. In plants, two MAPKs-MPK3 and MPK6-regulate diverse processes of development, environmental response and immunity. However, the mechanism that bridges these shared signalling

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