All Photos(1)

C2505

Sigma-Aldrich

Corticosterone

≥92%

Synonym(s):
11β,21-Dihydroxy-4-pregnene-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione
Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
Molecular Weight:
346.46
Beilstein:
2339601
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

biological source

synthetic (organic)

assay

≥92%

form

powder

mp

179-183 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Gene Information

Looking for similar products? Visit Product Comparison Guide

Application

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
  • as a stress inducing hormone in pregnant mice
  • to test its effect on depression-related behaviors in mice

Packaging

500 mg in glass bottle

Biochem/physiol Actions

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)
Lattin CR and Romero LM
The Journal of Experimental Biology, 217(14), 2601-2608 (2014)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups
Afadlal S, et al.
Neuroscience Letters, 470(1), 24-27 (2010)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service