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C3630

Sigma-Aldrich

Creatine monohydrate

≥98%

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Synonym(s):
Creatine hydrate, Creatine, monohydrate, N-(aminoiminomethyl)-N-methyl-glycine hydrate
Empirical Formula (Hill Notation):
C4H9N3O2 · H2O
CAS Number:
Molecular Weight:
149.15
Beilstein:
7942755
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

Assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

292 °C

SMILES string

O.CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2

InChI key

MEJYXFHCRXAUIL-UHFFFAOYSA-N

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This Item
P7936L9037T5816
Creatine monohydrate ≥98%

Sigma-Aldrich

C3630

Creatine monohydrate

-
L-Lysine monohydrate BioReagent, suitable for cell culture, from non-animal source

Sigma-Aldrich

L9037

L-Lysine monohydrate

Essential+ Grade
Tricine BioPerformance Certified, suitable for cell culture, ≥99% (titration)

Sigma-Aldrich

T5816

Tricine

Premium Grade
form

powder

form

powder

form

crystalline powder

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

color

white to off-white

color

white

color

white

color

-

mp

292 °C

mp

-

mp

215 °C

mp

187 °C

Application

Creatine (Cr) and phosphocreatine (PCr) are involved with rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). Creatine may be used as a supplement to study its uptake mechanism and metabolism of action.

Biochem/physiol Actions

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Yohei Tomita et al.
Diabetologia, 64(1), 70-82 (2020-10-26)
Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes
Caro-Lyne DesRoches et al.
Gene, 565(2), 187-191 (2015-04-12)
Creatine transporter deficiency (CRTR-D) is an X-linked inherited disorder of creatine transport. All males and about 50% of females have intellectual disability or cognitive dysfunction. Creatine deficiency on brain proton magnetic resonance spectroscopy and elevated urinary creatine to creatinine ratio
Andrina Stäubli et al.
Human molecular genetics, 26(21), 4203-4214 (2017-11-01)
Membrane transporters influence biological functions in the ocular lens. Here, we investigate the monocarboxylate transporter 12 (MCT12), also called creatine transporter 2 (CRT2), which is found in the ocular lens and is involved in cataract. As the age-related form affects
Clare E Turner et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(4), 1773-1780 (2015-01-30)
Impairment or interruption of oxygen supply compromises brain function and plays a role in neurological and neurodegenerative conditions. Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular
Domenic A LaRosa et al.
Pediatric research, 80(6), 852-860 (2016-07-29)
Maternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles. Pregnant spiny mice were fed a

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