Merck
All Photos(2)

D0162

Sigma-Aldrich

2′,3′-Dideoxyinosine

≥98% (HPLC)

Synonym(s):
ddI, ddIno
Empirical Formula (Hill Notation):
C10H12N4O3
CAS Number:
Molecular Weight:
236.23
Beilstein:
3619529
MDL number:
PubChem Substance ID:
NACRES:
NA.55

Quality Level

assay

≥98% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

InChI key

BXZVVICBKDXVGW-NKWVEPMBSA-N

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Related Categories

Packaging

100 mg in poly bottle
1, 5, 25 mg in glass bottle

Biochem/physiol Actions

Nucleotide antagonist

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Elizabeth Ojewole et al.
Planta medica, 78(4), 354-361 (2011-12-14)
The buccal mucosal route offers several advantages but the delivery of certain drugs can be limited by low membrane permeability. This study investigated the buccal permeability properties of didanosine (ddI) and assessed the potential of Aloe vera gel (AVgel) as
Alejandro Arenas-Pinto et al.
Antiviral therapy, 17(2), 275-282 (2012-02-02)
Genetic predisposition to dideoxynucleoside-induced mitochondrial dysfunction might be related to mitochondrial DNA (mtDNA) polymorphisms. Severe hyperlactataemia is probably the best model to assess such a predisposition. For this exploratory study in White European and Black African HIV-infected adults, hypervariable region
Gilles Casano et al.
Bioorganic & medicinal chemistry, 18(16), 6012-6023 (2010-07-20)
In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial
Jan Balzarini et al.
European journal of medicinal chemistry, 44(1), 303-311 (2008-04-19)
A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral potency (EC(50)=0.67 microM). The new
Yuan-Zhen Xiong et al.
European journal of medicinal chemistry, 43(6), 1230-1236 (2007-09-18)
A series of novel 6-naphthyloxy substituted DATA analogues bearing different substituents on the C-6 position of triazine ring were synthesized and evaluated for their in vitro anti-HIV activity in MT-4 cells. The results demonstrated that most of the compounds in

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