cell culture | mammalian: suitable
262-264 °C (lit.)
methanol: 25 mg/mL
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6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane and slightly soluble in chloroform.
The tissue culture grade product is dissolved in ethanol at a concentration of 1 mg/ml forming a clear, colorless solution. It is also possible to prepare a stock solution of dexamethasone in DMSO at 1.5 mM.
References can be found on the product detail page:Migliorati, G., et al., Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes. Pharmacol Res., 30(1), 43-52 (1994).Bansal, N., et al., Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. FASEB J. 5(2), 211-6 (1991).Shiao, R.T., et al., Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Leuk. Lymphoma, 17(5-6), 485-494 (1995).Migliorati, G., et al, Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes. Immunology, 81(1), 21-26 (1994).
Dexamethasone solutions are stable for at least 30 days when stored at 4 °C and protected from light. The solution may be aliquoted and stored at -20 °C. However, insufficient information is available to assess the shelf-life of the frozen solution.
The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.
The product has a 5 year shelf life.
Product D2915 is water soluble.
We do not perform animal studies with our products, but it can be used in cell culture (D2915 - cell culture grade version, or USP grade product D9184).
No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.