All Photos(1)

D5946

Sigma-Aldrich

PD 150606

≥97% (HPLC)

Synonym(s):
(2Z)-3-(4-iodophenyl)-2-mercapto-2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid
Empirical Formula (Hill Notation):
C9H7IO2S
CAS Number:
Molecular Weight:
306.12
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥97% (HPLC)

form

powder

storage condition

protect from light

color

yellowish

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)\C(S)=C\c1ccc(I)cc1

InChI

1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-

InChI key

DJCVSFWGKYHMKH-YVMONPNESA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PD 150606 is a selective; cell-permeable; non-peptide; uncompetitive calpain inhibitor.

Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Shuchen Hsieh et al.
Journal of nanoscience and nanotechnology, 9(5), 2894-2901 (2009-05-21)
Aminopropylsilatrane (AP-silatrane) was investigated as an adhesive layer for anchoring Au nanoparticles on silicon substrates. We compared the preparation procedure and film quality of the AP-silatrane films to those of 3-aminopropyltriethoxysilane (APTES), which is commonly used for nanoparticle attachment on
Rosalie Heilig et al.
Life science alliance, 3(6) (2020-04-30)
Caspase-1 drives a lytic inflammatory cell death named pyroptosis by cleaving the pore-forming cell death executor gasdermin-D (GSDMD). Gsdmd deficiency, however, only delays cell lysis, indicating that caspase-1 controls alternative cell death pathways. Here, we show that in the absence
Debora Gentile et al.
Biochemical and biophysical research communications, 533(4), 764-769 (2020-09-30)
The molecular target and mechanism by which d-limonene induces LC3 lipidation and autophagosome formation remain elusive. Here, we report that this monoterpene rapidly enhances Ca2+ levels in SH-SY5Y cells; yet this effect does not lead to calpain- or caspase-mediated proteolysis
Hong Wang et al.
Journal of inorganic biochemistry, 172, 16-22 (2017-04-19)
Calcium, as a ubiquitous second messenger, governs a large array of cellular processes and is necessary for cell survival. More recently, it was observed that the cytosolic Ca
Elina Välimäki et al.
Journal of immunology (Baltimore, Md. : 1950), 197(8), 3315-3325 (2016-09-18)
Extracellular ATP is an endogenous danger signal that is known to activate inflammatory responses in innate immune cells, including macrophages. Activated macrophages start to secrete proteins to induce an immune response, as well as to recruit other immune cells to

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