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F8190

Sigma-Aldrich

Fucoidan from Fucus vesiculosus

≥95%

Synonym(s):
Fucoidin
CAS Number:
MDL number:

Quality Level

biological source

algae (Fucus Vesiculosus)

assay

≥95%

form

powder

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General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Fucus vesiculosus has been to:
  • study the application of heparin red in detecting fucoidan
  • study its bioactivity as an antimicrobial agent
  • study its effects on advanced glycation end-products

Packaging

500 mg in poly bottle

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis
Shinichi H et al.
Scientific Reports, 8(1), 5901-5901 (2018)
Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy.
Zhang, et al.
Biomedicine and Pharmacotherapy, 130, 110534-110534 (2021)
Fanlu Wang et al.
Marine drugs, 19(4) (2021-04-04)
Fucoidans, sulfated polysaccharides extracted from brown algae, are marine products with the potential to modulate bone formation and vascularization processes. The bioactivity and safety of fucoidans are highly associated with their chemical structure, which may vary with algae species and
Bioactivity of Fucoidan as an Antimicrobial Agent in a New Functional Beverage
Poveda-Castillo et al.
Becker-Shaffer's Diagnosis and Therapy of the Glaucomas (2018)
Li-Mei Chen et al.
Scientific reports, 7(1), 11864-11864 (2017-09-21)
Low-molecular-weight Fucoidan (Oligo-Fucoidan) is a sulfated polysaccharide that has a variety of biological effects and has also been shown to have beneficial health effects. However, the molecular mechanisms underlying the therapeutic effects of Oligo-Fucoidan in patients with cancer remain unclear.

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