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F8315

Sigma-Aldrich

Fucoidan from Undaria pinnatifida

≥95%

CAS Number:
NACRES:
NA.25

Quality Level

biological source

algae (Undaria pinnatifida)

assay

≥95%

form

powder

General description

Fucoidan has a complex chemical composition. It contains mannose, galactose, glucose, xylose and other monosaccharides. It is also composed of uronic acids, acetyl groups and protein.
Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Undaria pinnatifida has been used to assess its antimicrobial potential in vitro.

Packaging

500 mg in poly bottle

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation which subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Fucoidan: structure and bioactivity
Li B, et al.
Molecules (Basel), 13(8), 1671-1695 (2008)
Arumugam Ponnan et al.
Environmental science and pollution research international, 27(25), 31760-31766 (2020-06-07)
Fucoidan is a unique bioactive and dietary polymer enriched mainly in the cell wall matrix of the brown seaweeds. This present study was intended to reveal the antigenotoxicity effect of fucoidan on 4-nitroquinolin-1-oxide (4-NQO) induced genetics damage and apoptosis in
Xiang Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1661-1667 (2014-06-07)
Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic plaques have a strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques, but not on the endothelium overlying inactive fibrous plaques. We proposed a new approach for noninvasive
Anna Pielesz et al.
The Analyst, 140(13), 4599-4607 (2015-06-02)
Differential scanning calorimetry (DSC) and thermogravimetric (TGA) investigations, acetate electrophoresis (CAE), Fourier-transform infrared spectrometry (FTIR), scanning electron microscopy (SEM) analysis and microbiological procedures were all carried out after heating the samples to a temperature sufficient for simulating a burn incident.
Wentong Cui et al.
Laboratory investigation; a journal of technical methods and pathology, 94(4), 382-393 (2014-03-13)
Endothelial dysfunction, characterized by impairment of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) bioavailability, has been implicated in diabetic cardiovascular pathogenesis. In this study, low-molecular-weight fucoidan (LMWF), which has multiple biological activities including anti-inflammatory and anti-oxidative properties, was

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