Merck
All Photos(4)

G1626

Sigma-Aldrich

L-Glutamic acid monosodium salt hydrate

≥99% (HPLC), powder

Synonym(s):
Monosodium glutamate, L-Glutamic acid monosodium salt, Glu, MSG, (S)-2-Aminopentanedioic acid
Empirical Formula (Hill Notation):
C5H8NNaO4 · xH2O
CAS Number:
Molecular Weight:
169.11 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.32

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Application

L-Glutamic acid monosodium salt hydrate has been used-
  • as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine
  • as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice
  • as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce′s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants
  • as a component of the stock solution for the equilibration of intracellular and extracellular [H+] in segmental nerves obtained from the ventral ganglion of Drosophila larvae
  • as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage

Packaging

1 kg in poly bottle
100, 500 g in poly bottle

Biochem/physiol Actions

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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João Carlos Campanharo et al.
Current microbiology, 46(2), 99-102 (2003-01-10)
For the first time, growth curves are shown for the phytopathogen Xylella fastidiosa on traditional growth media such as PW (periwinkle wilt), BCYE (buffered charcoal yeast extract), and on new ones such as GYE (glutamate yeast extract) and PYE (phosphate
Bo Løfgren et al.
Experimental physiology, 95(1), 140-152 (2009-09-01)
We have found that cardioprotection by l-glutamate mimics protection by classical ischaemic preconditioning (IPC). We investigated whether the effect of IPC involves amino acid transamination and whether IPC modulates myocardial glutamate metabolism. In a glucose-perfused, isolated rat heart model subjected
Serum-free media for neural cell cultures.
Price, P J, and Gregory J. B
Protocols for Neural Cell Culture, 255-264 (2001)
Adam J Rossano et al.
The Journal of physiology, 591(7), 1691-1706 (2013-02-13)
All biochemical processes, including those underlying synaptic function and plasticity, are pH sensitive. Cytosolic pH (pH(cyto)) shifts are known to accompany nerve activity in situ, but technological limitations have prevented characterization of such shifts in vivo. Genetically encoded pH-indicators (GEpHIs)
R L Barker et al.
The Journal of clinical investigation, 88(3), 798-805 (1991-09-01)
Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine. MBP has been localized on damaged helminths and tissues in hypersensitivity diseases including bronchial asthma. The

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