K8625

L-Kynurenine

≥98% (HPLC)

• Synonym(s): β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
• Empirical Formula (Hill Notation): C₁₀H₁₂N₂O₃
• CAS Number: 2922-83-0
• Molecular Weight: 208.21
• MDL number: MFCD00069912
• PubChem Substance ID: 24896246

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• mp: 219 °C
• application(s): detection
• SMILES string: N[C@@H](CC(=O)c1ccccc1N)C(O)=O
• InChI: 1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
• InChI key: YGPSJZOEDVAXAB-QMMMGPOBSA-N

Description

Application

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.

Biochem/physiol Actions

L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases. L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.

Key intermediate in the breakdown pathway of tryptophan.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves