L5647

Lidocaine hydrochloride monohydrate

solid

• Synonym(s): 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
• Empirical Formula (Hill Notation): C₁₄H₂₂N₂O · HCl · H₂O
• CAS Number: 6108-05-0
• Molecular Weight: 288.81
• EC Number: 200-803-8
• MDL number: MFCD00150329
• PubChem Substance ID: 24277718

Properties

• form: solid
• Quality Level: 200
• color: white
• solubility: H₂O: soluble
• SMILES string: Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
• InChI key: YECIFGHRMFEPJK-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Description

General description

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

Application

Lidocaine hydrochloride monohydrate has been used:

• in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
• to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
• For inhibition of glial cells in brain tissue samples.

Packaging

15, 100, 250 g

Biochem/physiol Actions

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves