L5647

Sigma-Aldrich

Lidocaine hydrochloride monohydrate

solid

Synonym(s):
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
Molecular Weight:
288.81
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

form

solid

color

white

solubility

H2O: soluble

SMILES string

Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2

InChI key

YECIFGHRMFEPJK-UHFFFAOYSA-N

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General description

Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life.

Application

Lidocaine hydrochloride monohydrate has been used:
  • in the preparation of drug composite for the controlled delivery in vitro, evaluated by drug release profile in ultra-high performance liquid chromatography (UPLC) and as a reference standard for fourier transform infrared spectroscopy (FT-IR).
  • to record dose dependent response of sodium voltage (Nav1.7) channels in the injection-molded polymer device.
  • For inhibition of glial cells in brain tissue samples.

Packaging

15, 100 g in poly bottle

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

pictograms

Skull and crossbones

signalword

Danger

hcodes

hazcat

Acute Tox. 3 Oral

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Ion channel recordings on an injection-molded polymer chip
Tanzi S, et al.
Lab on a chip, 13(24), 4784-4793 (2013)
Giovanni Sarnelli et al.
Journal of neuroinflammation, 15(1), 94-94 (2018-03-27)
Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity....
Nienke van Staaveren et al.
Scientific reports, 10(1), 12978-12978 (2020-08-02)
The gut-microbiota-brain axis is implicated in the development of behavioural disorders in mammals. As such, its potential role in disruptive feather pecking (FP) in birds cannot be ignored. Birds with a higher propensity to perform FP have distinct microbiota profiles...
HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system
Esposito G, et al.
Scientific Reports, 7(1), 7735-7735 (2017)
Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery
Dubnika A, et al.
Ceramics International, 43(4), 3698-3705 (2017)

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