M8699

(R)-MG132

• Synonym(s): Z-L-Leu-D-Leu-L-Leu-al
• Empirical Formula (Hill Notation): C₂₆H₄₁N₃O₅
• CAS Number: 1211877-36-9
• Molecular Weight: 475.62

Properties

• assay: ≥98%
• Quality Level: 200
• solubility: DMSO or DMF: 25 mg/mL
• storage temp.: −20°C
• SMILES string: CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O

Description

Application

(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.

Packaging

1 mg

Biochem/physiol Actions

MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.

Physical form

crystalline solid or supercooled liquid

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable