Merck
All Photos(3)

O4876

Sigma-Aldrich

Oligomycin from Streptomyces diastatochromogenes

≥90% total oligomycins basis (HPLC)

CAS Number:
Beilstein:
7615308
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥90% total oligomycins basis (HPLC)

form

powder

antibiotic activity spectrum

fungi

Mode of action

enzyme | inhibits

storage temp.

−20°C

InChI

1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+

InChI key

MNULEGDCPYONBU-ZUSSGZTJSA-N

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General description

Chemical structure: macrolide

Application

Oligomycin from Streptomyces diastatochromogenes is used:
  • in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.
  • in ATP-linked respiration and maximal capacity respiration assay in astrocytes.
  • in measurement of oxygen consumption rate (OCR) and extracellular acidification rates in breast cancer cell lines.

Packaging

25 mg in poly bottle
5 mg in glass bottle
100, 250 mg in glass bottle

Biochem/physiol Actions

Oligomycin belongs to the macrolide group of antibiotics. It inhibits mitochondrial ATP-synthase enzyme and phosphoryl group transfer. Oligomycin interacts with ATP synthase subunit-c in the Fo portion and impairs proton transport.

Other Notes

A mixture of oligomycins A, B, and C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Oligomycin frames a common drug-binding site in the ATP synthase
Symersky J, et al.
Proceedings of the National Academy of Sciences of the USA, 109(35), 13961-13965 (2012)
Synthesis and cytotoxicity of oligomycin A derivatives modified in the side chain
Lysenkova LN, et al.
Bioorganic & Medicinal Chemistry, 21(11), 2918-2924 (2013)
LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
Furth N, et al.
Life science alliance, 1(5), e201800171-e201800171 (2018)
Oligomycin, inhibitor of the F 0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis
Shchepina LA, et al.
Oncogene, 21(53), 8149-8149 (2002)
Drug screening identifies Sigma-1-Receptor as a target for the therapy of VWM leukodystrophy
Atzmon A, et al.
Frontiers in Molecular Neuroscience, 11 (2018)

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