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P1867

Sigma-Aldrich

Plasmin from human plasma

lyophilized powder, ≥2.0 units/mg protein

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Synonym(s):
Fibrinolysin
CAS Number:
9001-90-5
Enzyme Commission number:
3.4.21.7 (BRENDA, IUBMB)
EC Number:
232-640-3
MDL number:
MFCD00131921
eCl@ss:
42030239
NACRES:
NA.54

form

lyophilized powder

Quality Level

200

specific activity

≥2.0 units/mg protein

impurities

HIV, Hepatitis B and Hepatitis C, tested negative

UniProt accession no.

P00747

application(s)

diagnostic assay manufacturing

storage temp.

−20°C

Gene Information

human ... PLG(5340)

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This Item
P7999SRP6518P9156
Plasmin from human plasma lyophilized powder, ≥2.0 units/mg protein

Sigma-Aldrich

P1867

Plasmin from human plasma

Sigma-Aldrich

Sigma-Aldrich

P7999

Plasminogen from human plasma

Plasminogen from human plasma ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6518

Plasminogen from human plasma

Plasminogen from bovine plasma lyophilized powder, ≥2.0 units/mg protein

Sigma-Aldrich

P9156

Plasminogen from bovine plasma

specific activity

≥2.0 units/mg protein

specific activity

≥2.0 units/mg protein

specific activity

-

specific activity

≥2.0 units/mg protein

impurities

HIV, Hepatitis B and Hepatitis C, tested negative

impurities

-

impurities

-

impurities

-

UniProt accession no.

P00747

UniProt accession no.

P00747

UniProt accession no.

P00747

UniProt accession no.

P00747, P06868

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

application(s)

histology

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

General description

Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes.

Application

A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. It has also been used in a study to investigate activation of human epithelial sodium channel (ENaC) by plasmin and chymotrypsin.

Biochem/physiol Actions

It is inhibited by α 2-antiplasmin and its interaction with fibrin is blocked. It digests the N-terminal region of the cytoplasmic protein αsynuclein preventing its uptake by surrounding cells.
Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products.
pH Optimum: 8.5
pH 7.5: ~40% of maximal activity, pH 9.5: ~50% of maximal activity
Temperature Optimum: 37 °C with rapid inactivation at 56 °C

Packaging

Package size based on protein content

Unit Definition

One unit will produce one μmole of p-Nitroanilide from D-Val-Leu-Lys-p-Nitroanilide per minute at pH 7.5 at 37 °C.

Physical form

Lyophilized powder containing sodium phosphate, mannitol, and NaCl.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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25G
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S Müllertz et al.
The Biochemical journal, 159(3), 545-553 (1976-12-01)
A complex between plasmin and an inhibitor was isolated by affinity chromatography from urokinase-activated human plasma. The complex did not react with antibodies against any of the known proteinase inhibitors in plasma. A rabbit antiserum against the complex was produced.
Tatiana Syrovets et al.
Journal of leukocyte biology, 92(3), 509-519 (2012-05-09)
The serine protease plasmin generated from its zymogen plasminogen is best known for its function as a key enzyme of the fibrinolytic cascade. However, beyond fibrinolysis, plasmin has a number of crucial functions in a variety of processes, including inflammation.
Efrat Shavit-Stein et al.
PloS one, 16(3), e0248431-e0248431 (2021-03-16)
Ischemic stroke is a common and debilitating disease with limited treatment options. Protease activated receptor 1 (PAR1) is a fundamental cell signaling mediator in the central nervous system (CNS). It can be activated by many proteases including thrombin and plasmin
Dejun Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(33) (2021-08-13)
Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function
Peter Stalmans et al.
Investigative ophthalmology & visual science, 54(10), 6620-6627 (2013-08-29)
To characterize the levels of active ocriplasmin over a period of ascending time points (range, 5 minutes to 7 days) from intravitreal injection of a 125-μg dose to sampling. During this 7-week controlled, open-label, phase 2 study, a single intravitreal
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