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Poly-L-lysine hydrobromide

mol wt 70,000-150,000, lyophilized powder, γ-irradiated, BioXtra, suitable for cell culture

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product line



lyophilized powder

mol wt



pkg of 5 mg


cell culture | mammalian: suitable


H2O: soluble 50 mL/vial, clear, colorless

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storage temp.


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Recommended as a cell culture substratum when using 0.5 ml of a 0.1 mg/ml solution to coat 25 cm2. Optimal conditions for attachment must be determined for each cell line and application.
Poly-L-lysine hydrobromide has been used to precoat glass bottom dishes used for in vitro cell culture.


Poly-L-lysine is a positively charged amino acid polymer with approximately one HBr per lysine residue. The hydrobromide allows the poly-L-lysine to be in a crystalline form soluble in water. A small amount of product may be found in the beta structure because the HBr interferes with hydrogen bonding between amino and either the carboxyl groups or N or O containing moieties.


Sterile solutions are stable for up to 2 years when stored at 2-8°C. It should be stored desiccated at -20°C.

Analysis Note

Molecular weight based on viscosity. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Rahul Munshi et al.
Frontiers in neuroscience, 12, 560-560 (2018-08-30)
Determining the role and necessity of specific neurons in a network calls for precisely timed, reversible removal of these neurons from the circuit via remotely triggered transient silencing. Previously, we have shown that alternating magnetic field mediated heating of magnetic
Eberhard Grambow et al.
Platelets, 28(5), 509-517 (2016-11-08)
The volatile transmitter hydrogen sulfide (H
CXCR4 controls ventral migration of sympathetic precursor cells
Kasemeier KJC, et al.
The Journal of Neuroscience, 30(39), 13078-13088 (2010)
Oriane Mercati et al.
Biology open, 2(3), 324-334 (2013-03-23)
The neural cell-adhesion molecules contactin 4, contactin 5 and contactin 6 are involved in brain development, and disruptions in contactin genes may confer increased risk for autism spectrum disorders (ASD). We describe a co-culture of rat cortical neurons and HEK293
Does NAD (P) H oxidase-derived H 2 O 2 participate in hypotonicity-induced insulin release by activating VRAC in beta-cells?
Crutzen R, et al.
Pfluegers Archiv, 463(2), 377-390 (2012)

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