S1885

Sigma-Aldrich

Suberic acid bis(N-hydroxysuccinimide ester)

≥95%, powder

Synonym(s):
Disuccinimidyl suberate, Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)
Empirical Formula (Hill Notation):
C16H20N2O8
CAS Number:
Molecular Weight:
368.34
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

solubility

chloroform: 50 mg/mL
DMF: soluble
aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.)

storage temp.

2-8°C

SMILES string

O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

InChI key

ZWIBGKZDAWNIFC-UHFFFAOYSA-N

Related Categories

General description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

Application

Suberic acid bis(N-hydroxysuccinimide ester) has been:
  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers

Packaging

500 mg in poly bottle
1, 5 g in poly bottle

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Wei Wu et al.
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Zebrafish have the capacity to regenerate lost tissues and organs. Amputation of the caudal fin results in a rapid, transient increase in H
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Baskin DS, et al.
Analytical Biochemistry, 404(2), 118-126 (2010)
Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor
Zhou X, et al.
Cell death discovery, 5(1), 18-18 (2018)
Scutellarin suppresses NLRP3 inflammasome activation in macrophages and protects mice against bacterial sepsis
Liu Y, et al.
Frontiers in Pharmacology, 8, 975-975 (2018)
Bastien Casu et al.
Scientific reports, 7(1), 14907-14907 (2017-11-04)
The increasing frequency of antimicrobial resistance is a problem of global importance. Novel strategies are urgently needed to understand and inhibit antimicrobial resistance gene transmission that is mechanistically related to bacterial virulence functions. The conjugative transfer of plasmids by type...

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