Merck
  • S7076
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S7076

Sigma-Aldrich

SB 202190 monohydrochloride hydrate

≥98% (HPLC)

All Photos(1)
Synonym(s):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
Empirical Formula (Hill Notation):
C20H14FN3O · HCl · xH2O
CAS Number:
350228-36-3
Molecular Weight:
367.80 (anhydrous basis)
MDL number:
MFCD17215958
PubChem Substance ID:
329824576
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white to beige

solubility

DMSO: ≥12 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2

Inchi Key

CZZOICWZVYZUNP-UHFFFAOYSA-N

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SB 202190 monohydrochloride hydrate ≥98% (HPLC)

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Benzamil hydrochloride hydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

solid

color

white to beige

color

yellow

color

white to beige

color

yellow

solubility

DMSO: ≥12 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

originator

GlaxoSmithKline

originator

GlaxoSmithKline

originator

GlaxoSmithKline

originator

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Application

SB 202190 may be used to inhibit p38-mediated cell signaling.
SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium and organoid culture medium It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.

Biochem/physiol Actions

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.
SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.
SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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