Merck
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SAB2500443

Sigma-Aldrich

Anti-GAD1 (Isoform GAD67) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-SCP, Anti-Glutamate decarboxylase 1, Anti-GAD, Anti-FLJ45882
MDL number:
NACRES:
NA.41

Quality Level

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat, pig, canine, bovine

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... GAD1(2571)

General description

Glutamate decarboxylase 1 (GAD1) or GAD67 has a molecular weight of 67kDa. It is one of the two isoforms of GAD protein. GAD1 is present in the cell bodies of most γ-amino butyric acid (GABA)-containing neurons in the central nervous system. The protein is expressed in interneurons of the basolateral amygdala (BLA) and in the central amygdala (CEA) in GABA-ergic projection neurons. The gene encoding GAD1 is localized on human chromosome 2q31.1.

Immunogen

Peptide with sequence C-PDSPQRREKLHK from the internal region of the protein sequence according to NP_000808.2.

Biochem/physiol Actions

Glutamate decarboxylase 1 (GAD1) is the predominant γ-amino butyric acid (GABA) synthesizing protein and has a role in the rate-limiting step in the synthesis of GABA from glutamate in brain. GAD1 gene might be linked to genetic susceptibility to schizophrenia. It is also associated with stiff man syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificate of Analysis

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Certificate of Origin

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