Glutamate decarboxylase 1 (GAD1) or GAD67 has a molecular weight of 67kDa. It is one of the two isoforms of GAD protein. GAD1 is present in the cell bodies of most γ-amino butyric acid (GABA)-containing neurons in the central nervous system. The protein is expressed in interneurons of the basolateral amygdala (BLA) and in the central amygdala (CEA) in GABA-ergic projection neurons. The gene encoding GAD1 is localized on human chromosome 2q31.1.
Peptide with sequence C-PDSPQRREKLHK from the internal region of the protein sequence according to NP_000808.2.
Glutamate decarboxylase 1 (GAD1) is the predominant γ-amino butyric acid (GABA) synthesizing protein and has a role in the rate-limiting step in the synthesis of GABA from glutamate in brain. GAD1 gene might be linked to genetic susceptibility to schizophrenia. It is also associated with stiff man syndrome.
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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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