SAB2500443

Anti-GAD1 (Isoform GAD67) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-SCP, Anti-Glutamate decarboxylase 1, Anti-GAD, Anti-FLJ45882
• MDL number: MFCD01322096
• NACRES: NA.41

Properties

• Quality Level: 100
• biological source: goat
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human, rat, pig, canine, bovine
• technique(s): indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: Q99259
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... GAD1(2571)

Description

General description

Glutamate decarboxylase 1 (GAD1) or GAD67 has a molecular weight of 67kDa. It is one of the two isoforms of GAD protein. GAD1 is present in the cell bodies of most γ-amino butyric acid (GABA)-containing neurons in the central nervous system. The protein is expressed in interneurons of the basolateral amygdala (BLA) and in the central amygdala (CEA) in GABA-ergic projection neurons. The gene encoding GAD1 is localized on human chromosome 2q31.1.

Immunogen

Peptide with sequence C-PDSPQRREKLHK from the internal region of the protein sequence according to NP_000808.2.

Biochem/physiol Actions

Glutamate decarboxylase 1 (GAD1) is the predominant γ-amino butyric acid (GABA) synthesizing protein and has a role in the rate-limiting step in the synthesis of GABA from glutamate in brain. GAD1 gene might be linked to genetic susceptibility to schizophrenia. It is also associated with stiff man syndrome.

Features and Benefits

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Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.