Monoclonal Anti-SAMHD1 (mouse IgG1 isotype) is derived from the hybridoma SM1.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is expressed at basal levels in a large number of tissues but is highly expressed in dendritic cells and other cells of the myeloid lineage. It is made up of sterile alpha motif (SAM) and an HD domain which occur in tandem. SAMDH1 is mapped on the human chromosome at 20q11.23.
Monoclonal Anti-SAMHD1 recognizes human and monkey SAMHD1.
synthetic peptide corresponding to a sequence at the C-terminal region of human SAMHD1
Monoclonal Anti-SAMHD1 antibody produced in mouse may be used in:
- flow cytometry
Mutations in SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) are associated with Aicardi-Goutières syndrome (AGS), a severe genetic infantile encephalopathy characterized by chronic cerebrospinal fluid lymphocytosis, elevated levels of interferon-α. Lower levels of SAMHD1 leads to the accumulation of full-length human immunodeficiency virus (HIV) DNA.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation beforeuse. Working dilution samples should be discarded if not used within 12 hours.
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