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SML1094

Sigma-Aldrich

CHIR 98014

≥98% (HPLC)

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Synonym(s):
N-6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine, CHIR-98014
Empirical Formula (Hill Notation):
C20H17Cl2N9O2
CAS Number:
252935-94-7
Molecular Weight:
486.31
MDL number:
MFCD10565922
PubChem Substance ID:
329825471
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 0.5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

NC1=C(C=CC(NCCNC2=NC(C3=C(Cl)C=C(Cl)C=C3)=C(N4C=CN=C4)C=N2)=N1)[N+]([O-])=O

InChI

1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)

InChI key

MDZCSIDIPDZWKL-UHFFFAOYSA-N

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CHIR 98014 ≥98% (HPLC)

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SML1094

CHIR 98014

CHIR99021 ≥98% (HPLC)

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SML1046

CHIR99021

CHIR124 ≥98% (HPLC)

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SML3054

CHIR124

CBR-5884 ≥98% (HPLC)

Sigma-Aldrich

SML1656

CBR-5884

form

powder

form

powder

form

powder

form

paste

color

white to brown

color

white to light brown

color

white to beige

color

white to beige

solubility

DMSO: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons. It has also been used as a Wnt/β-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons.

Biochem/physiol Actions

CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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