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T6381

Supelco

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane

with 1% trimethylchlorosilane, for GC derivatization, LiChropur

Synonym(s):
BSTFA + TMCS
Linear Formula:
CF3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
Molecular Weight:
257.40
Beilstein:
2050024
MDL number:
PubChem Substance ID:

Quality Level

grade

for GC derivatization

quality

LiChropur
with 1% trimethylchlorosilane

contains

1% trimethylchlorosilane as additive

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

application(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.384 (lit.)

bp

45-50 °C/14 mmHg (lit.)

density

0.97 g/mL (lit.)

storage temp.

2-8°C

SMILES string

C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F

InChI

1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+

InChI key

XCOBLONWWXQEBS-KPKJPENVSA-N

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General description

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane is a silylating reagent generally used in estrogenic steroid hormone identification and quantification.

Application

BSTFA+TMCS has been used as derivatizing reagent for GC-MS determination of natural and synthetic estrogenic steroids.

Packaging

Sealed ampules contain 1 ml. Gram sizes are in screw-cap bottles.
Clear borosilicate glass, high hydrolytic resistance (Type I)

Other Notes

The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 3

Flash Point F

44.1 °F - closed cup

Flash Point C

6.7 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Pitfalls and solution for simultaneous determination of estrone and 17a-ethinylestradiol by gas chromatography?mass spectrometry after derivatization with N, O-bis (trimethylsilyl) trifluoroacetamide.
Zhang, Kai, and Yuegang Zuo.
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