≥1,000 NIH units/mg protein (E1%/280, 18.3)
HIV and HBsAg, source material tested negative
Diagnostic Assay Manufacturing
human ... F2(2147)
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Thrombin from any vertebrate species will clot the fibrinogen of virtually any other species. Fibrinogen from any mammalian source will cross-react with thrombin from any mammalian source, but it is not well known how thrombin and fibrinogen from different animals differ in their sequence. When any mammalian thrombin is injected into a different mammal, clotting will occur.
One NIH unit of thrombin is equivalent to approximately 1.8 International Unit (IU) of thrombin.
Thrombin from human plasma gave a clear very faint yellow solution when dissolved at 100 unit vial plus 1 ml of 28 mM sodium barbital, 0.125M sodium chloride, 1% BSA, 0.5% PEG, pH 7.35. Thrombin from bovine plasma (T4648) is soluble in water at 10 mg/mL.
By analogy to thrombin from bovine plasma (T4648), we expect stock solutions of thrombin from human plasma to be stable for one week kept refrigerated at 2-8° C. Since thrombin solutions adsorb to glass, it is recommended to aliquot the solutions in plastic tubes and store frozen at -20°C or colder for long term storage.
The isoelectric point (pI) range of the human thrombin isozymes is 6.35 - 7.6. The major isoform has a pI of 7.31.
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