U3003

Sigma-Aldrich

Uridine

powder, BioReagent, suitable for cell culture

Synonym(s):
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
Molecular Weight:
244.20
Beilstein/REAXYS Number:
754902
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

Quality Level

biological source

synthetic (organic)

product line

BioReagent

assay

≥99%

form

powder

application(s)

cell culture | mammalian: suitable

mp

163-167 °C (lit.)

solubility

H2O: 50 mg/mL

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

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General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is a substrate for nucleotide synthesis in living organisms by de- novo and salvage pathways.

Application

Uridine has been used:
  • as an inhibitor of schwann cell proliferation in rat dorsal root ganglia (DRG) neurons culture
  • as a medium supplement for epiblasts culture
  • as a component of 5-fluoro-2′-deoxyuridine stock solution used for neuronal culture

Packaging

5, 50 g in poly bottle

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like, treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine induces insulin resistance.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Characterisation of bovine epiblast-derived outgrowth colonies
Oestrup E, et al.
Reproduction, Fertility, and Development, 22(4), 625-633 (2010)
Preparation of rat brain aggregate cultures for neuron and glia development studies
Koito H and Li J
Journal of Visualized Experiments, 22(31), 625-633 (2009)
Biochemistry of uridine in plasma
Yamamoto T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 412(19-20), 17121724-17121724 (2011)
Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating
Jin GZ, et al.
Neuroscience Letters, 501(1), 10-14 (2011)
CAD mutations and uridine-responsive epileptic encephalopathy
Koch J, et al.
Brain, 140(2), 279286-279286 (2016)

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