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N-Nitrosodiethylamine solution

certified reference material, 5000 μg/mL in methanol

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certified reference material

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current certificate can be downloaded


ampule of 1 mL


5000 μg/mL in methanol


HPLC: suitable
gas chromatography (GC): suitable

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single component solution

storage temp.




InChI key


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Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Legal Information

TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC

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Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids



Certificate of Analysis

Certificate of Origin

Kei Tamura et al.
The Journal of toxicological sciences, 41(6), 801-811 (2016-11-18)
To clarify the major pathway of liver tumor development induced by imazalil (IMA), an imidazole fungicide, male constitutive androstane receptor (CAR)-knockout (CARKO) and wild-type (WT) mice were treated with IMA at 500 ppm in the diet up to 27 weeks...
Hao Hu et al.
International journal of medical sciences, 17(13), 1897-1908 (2020-08-14)
Retinal dehydrogenase 5 (RDH5) is an important enzyme in the visual cycle. Several studies have reported that the RDH family may play crucial roles in tumor prognosis. However, the role of RDH5 in tumor prognosis is still unclear. We examined...
Xu Zheng et al.
Nutrients, 10(3) (2018-03-03)
Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50...
L Verna et al.
Pharmacology & therapeutics, 71(1-2), 57-81 (1996-01-01)
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA...
Ziyan Wang et al.
Hepatology (Baltimore, Md.), 57(5), 1869-1881 (2013-01-10)
Hepatocellular carcinoma (HCC) is a devastating consequence of chronic inflammatory liver diseases. The goal of this study was to investigate whether Toll-like receptor 4 (TLR4) activity contributes to HCC initiation and progression in mice. A mouse model of diethylnitrosamine (DEN)-induced...

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