PHL89745

Oridonin

phyproof® Reference Substance

Synonym(s):
Isodonol, 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one
Empirical Formula (Hill Notation):
C20H28O6
CAS Number:
Molecular Weight:
364.43

grade

primary reference standard

product line

phyproof® Reference Substance

assay

≥98.0% (HPLC)

manufacturer/tradename

PhytoLab

Featured Industry

Food and Beverages

format

neat

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General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificate of Analysis

Certificate of Origin

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