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Chemical Biology

Image of Laboratory equipment used in biochemical research of carbohydrates including monosaccharides, disaccharides, oligosaccharides, and polysaccharides.

Chemical biology products incorporate the techniques and strengths of chemistry to address fundamentally important questions in biology, medicine, and drug discovery. Sigma-Aldrich® chemical biology products provide solutions, expertise, and industry leadership to advance your research. We offer a market-leading range of innovative products for conjugation strategies, such as azide-alkyne cycloaddition chemistry, as well as synthetic intermediates and building blocks for the synthesis of biomolecules, such as peptides, carbohydrates, and oligonucleotides.   

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The image depicts a 3D molecular model with nine red and seven black atoms representing oxygen and carbon

Carbohydrates

Our broad portfolio of highly pure carbohydrates are used widely as supplements to cell culture media and as building blocks in glycan and glycoconjugate synthesis.

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Click Chemistry Reagents

Our portfolio of click chemistry reagents includes a variety of azides, alkynes, catalysts, and ligands to accelerate your progress in chemical biology, polymer chemistry, bioconjugation, and drug discovery.

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This example of click chemistry scheme shows the Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC)of alkynes to azides to form 1,4-disubsituted-1,2,3-triazole

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The image depicts a colorful biochemical diagram illustrating the bioconjugation process where two blue spiky shapes labeled “Protein Protein Interaction” are transformed into a “Crosslinked Proteins” shape through the action of a “Crosslinker.”
Crosslinkers

Our portfolio of linkers and crosslinkers provide structural stability and reliability in protein-protein, protein-peptide, and peptide/protein-small molecule interactions for all your bioconjugation needs.

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3D model of a co-crystal structure with the PROTAC in green binding to the target in yellow and the E3 ubiquitin in pink for targeted protein degradation.
Protein Degrader Building Blocks

Our protein degrader building blocks are the easiest way to generate libraries of protein degraders, such as proteolysis targeting chimeras (PROTAC®...

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A scientist in a lab coat and blue gloves is examining a detailed blue 3D model of a molecular structure with blurred laboratory equipment in the background.
Chemical Biology Tools

Our chemical biology tools incorporate techniques and strengths of chemistry to address fundamentally important research in biology, medicine, and drug discovery. 

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carbohydrates (677)

PROTACs (189)

monosaccharides (187)

dPEGs<SUP>&#174;</SUP> (164)

building blocks (119)

polysaccharides (98)

amine (171)

carboxylic acid (99)

Boc (62)

NHS ester (45)

azide (45)

hydroxyl (28)

cross-linking reagent (310)

ligand-linker conjugate (138)

linker (90)

chemical modification reagent (41)

ligand (32)

chelator (13)
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Showing 1-20 of 1464
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Copper(I) bromide
945528

Copper(I) bromide

≥99.5%, purum

Sucrose
S0389

Sucrose

Molecular Biology, ≥99.5% (GC)

Copper(II) sulfate pentahydrate
209198

Copper(II) sulfate pentahydrate

ACS reagent, ≥98.0%

<SC>D</SC>-(+)-Glucose
G8270

D-(+)-Glucose

≥99.5% (GC)

Lipopolysaccharides from <I>Escherichia coli</I> O111:B4
L2630

Lipopolysaccharides from Escherichia coli O111:B4

purified by phenol extraction

<SC>D</SC>-(+)-Glucose
G7021

D-(+)-Glucose

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.5%

Sucrose
S9378

Sucrose

≥99.5% (GC)

<SC>D</SC>-(+)-Glucose solution
G8769

D-(+)-Glucose solution

45% in H2O, sterile-filtered, BioXtra, suitable for cell culture

<SC>D</SC>-Sorbitol
S1876

D-Sorbitol

≥98% (GC)

Lipopolysaccharides from <I>Escherichia coli</I> O111:B4
L4391

Lipopolysaccharides from Escherichia coli O111:B4

γ-irradiated, BioXtra, suitable for cell culture

Heparin sodium salt from porcine intestinal mucosa
H3149

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture

Heparin sodium salt from porcine intestinal mucosa
H3393

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg

<SC>D</SC>-(+)-Trehalose dihydrate
T9531

D-(+)-Trehalose dihydrate

≥99% (HPLC), from Saccharomyces cerevisiae

Sucrose
S7903

Sucrose

≥99.5% (GC), BioXtra

Sucrose
84097

Sucrose

BioUltra, Molecular Biology, ≥99.5% (HPLC)

Copper(II) sulfate
C1297

Copper(II) sulfate

ReagentPlus®, ≥99%

Lipopolysaccharides from <I>Escherichia coli</I> O55:B5
L2880

Lipopolysaccharides from Escherichia coli O55:B5

purified by phenol extraction

<SC>D-</SC>(−)-Fructose
F0127

D-(−)-Fructose

≥99% (HPLC)

<SC>L</SC>-(+)-Arabinose
A3256

L-(+)-Arabinose

≥99% (GC)

Fluorescein isothiocyanate–dextran
FD4

Fluorescein isothiocyanate–dextran

average mol wt 3,000-5,000

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