Chromatography Systems for Bioprocessing
Single-use and multi-use chromatography systems are critical factors for the successful separation of your valuable molecules. From pilot to process-scale, our systems are designed to provide robust, consistent performance with the processing flexibility you need. We also offer an unmatched portfolio of chromatography resins and membranes, backed by unparalleled applications and validation support. With this complete product offering, we continue to support you in your efforts to increase productivity and process efficiency. Our experts can help you find the right product for your chromatography process.
Products
NA12-51 Single Position Indicator
NA18 Diaphragm EPDM
NovAseptic Valve, Diaphragm, EPDM
ANNUAL SPARES KIT 250mm GA & GS COLUMNS
QS300 KIT OF ADJUSTER SEALS
QS100 KIT BED SUPPORT ADJUSTER 10µM
DIAM.800 INFLATABLE SEAL AIR KIT
QS300 GA GLASS TUBE LENGTH 550
ANNUAL SPARES KIT 300mm GA & GS COLUMNS
IP ISOPAK VALVE SEAL KIT
QS450 ACRYLIC TUBE LENGTH 550
Spare part, Mobius® Chrom, Pinch Valve
NO PCV 3/8"
Spare part, Electromagnetic Flowmeter
1/4in Qmax 3 L/min
PRESSURE GAUGE KIT DIGITAL 3/4" SAN
VALVE PINCH 6mm BORE 1/2" SANITARY ENDS
DIAM.1000 INFLATABLE SEAL AIR KIT
DIAM.440 INFLATABLE SEAL AIR KIT
CLAMP SANITARY 3/4" ST/STL
Spare parts for QS450 BOTTOM BED SUPPORT 20 µm FOR GLAS
Spare parts for QuikScale® Chromatography columns- size 450
IP630 BED SUPPORT SEAL KIT
BUBBLE TRAP DIA 60
Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is a fully automated, single-use solution to operate continuous closed capture chromatography. It manages process parameters in real time with reference to changing column load, surge feed tank load, and monitoring resin performance. Coupled with an in-line dilution capability and intuitive software, the 3 columns system allows complete control of the capture step of your fed-batch or perfusion bioprocess. The Mobius® Multi Column Capture system is suitable for bioreactor volumes ranging from 50 L to 2000 L. Learn more on multi column chromatography.
Mobius® Chrom Systems
The Mobius® Chrom systems are a flexible, automated, single- use chromatography systems that enable consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales. The innovative single-use flowpath reduces contamination risk and gives you the confidence to tackle any chromatography challenge. The systems deliver optimal operational flexibility for processes from 50 to 2,000 L with flow rates from 0.1 to 20 L /min, a 5:1 turn down ratio at process scale and enhanced isocratic and linear gradient accuracy. Its single-use flow path offers the flexibility to operate in functionally or fully closed mode.
CoPrime® biochromatography systems
CoPrime® biochromatography systems are designed to achieve optimum separation and purification of monoclonal antibodies, vaccines, plasma, and therapeutic proteins. The systems support rapid scale-up and are ideally suited for pilot and process scale. They are based on 50 years of process knowledge and engineering expertise, providing a configurable, intuitive process-scale purification solution. CoPrime® B and C sizes have an extended flow rate span and optimized performance for greater gradient accuracy and purification reproduction. The CoPrime® size C covers higher scales and allows scale-up directly from CoPrime™ B.
Related Resources
- Application Note: Multi-Column Chromatography for Efficient Polishing Purification
The studies in this application note focus on Ion Exchange (IEX) chromatography in bind/elute mode using the Mobius® Multi Column Capture system.
- Application Note: Efficient Protein A Capture in Intensified Processes: Process Characterization and Scalability
Assess the efficiency of continuous mAb capture from a clarified and filtered harvest cell culture fluid (HCCF), using the Mobius® Multi Column Capture system and evaluate process scalability.
- In-Line Dilution Capabilities of Mobius® Multi Column Capture System for Effective Buffer Management Strategies
Enhancing Intensified Chromatography Performance through Automated Buffer Dilution
- Application Note: Process Development and Scale-Up Strategy for the Mobius® Multi Column Capture System
A methodology for developing and scaling up a process for a multi-column capture operation using the Mobius® Multi Column Capture.
- Data Sheet: Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- Data Sheet: Mobius® Chrom Systems
The Mobius® Chrom systems are a flexible, automated, single-use chromatography systems that enable consistent and reliable separation and purification.
- Application Note: Multi-Column Capture
Prototype Tests for Monoclonal Antibody Capture During Project nextBioPharmDSP (Horizon 2020).
- Technical Brief: Mobius® Breez Microbioreactor
Mixing and Gas Transfer in the Mobius® Breez Microbioreactor – How It Works?
- Spare Parts List: Mobius® Multi Column Capture System
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Performance Guide: Mobius® Multi Column Capture System
The purpose of this document is to describe the performance of the Mobius® Multi Column Capture system and highlight the working principles of its innovative features.
- Data Sheet: CoPrime® Biochromatography Process-Scale System
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications.
- Poster: Horizon 2020 - Fully Connected Single-use Downstream Platform for mAb Production
Within the biopharmaceutical industry, there is a significant shift toward higher productivity processes resulting in improved economics without compromising robustness. Therefore, integrated continuous production technologies are of greatest interest.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Application Note: Implementation of Multi-Column Chromatography Systems
The Multi-Column Capture (MCC) System enables efficient primary capture through three column operation, supporting continuous feedstream processing.
- Performance Guide: Mobius® Chrom 10 System
Discover Mobius® Chrom 10 system’s key performance highlights for scalable chromatography in clinical and commercial purification.
- Performance Guide: Mobius® Chrom 2 System
Discover the Mobius® Chrom 2 system, fully automated with operational flexibility, designed to reduce cross-contamination in scalable chromatography.
Related Webinars
Multi-column chromatography is a bioprocessing technique where multiple columns are loaded in series and then cycled for elution, regeneration, and equilibration.
The benefits of a novel Protein A affinity membrane, used as a high productivity, truly single-use chromatography platform for intensified mAb purification.
CEX flow-through frontal chromatography for the removal of mAb aggregates as well as the conditions that influence the removal of these aggregates.
An overview of custom affinity chromatography technologies for vaccine purification.
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