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J Kolodziejczyk-Czepas et al.
Molecular and cellular biochemistry, 410(1-2), 229-237 (2015-09-10)
This study includes a comparative evaluation of antioxidant effects of plant extracts (1.5-50.0 μg/ml), derived from six clover (Trifolium) species: T. alexandrinum L., T. fragiferum L., T. hybridum L., T. incarnatum L., T. resupinatum var. majus Boiss., and T. resupinatum
Tara L Vollmerhausen et al.
Journal of medical microbiology, 63(Pt 12), 1575-1583 (2014-10-10)
We investigated the ability of Escherichia coli isolated from septic patients with urinary tract infection (UTI) to translocate through the gastrointestinal (GI) tract of the same patients using cell-culture models. Forty-seven hospitalized patients with urosepsis were included in this study.
Sang Hun Lee et al.
Genes, chromosomes & cancer, 54(6), 353-360 (2015-03-31)
Ovarian microcystic stromal tumor (MCST) is a very rare neoplasm; hence, its nomenclature was recently designated as "Distinctive morphologic and immunohistochemical features" in 2009. Its exact origin, etiological genetic alterations, and background are not yet clearly known. Familial adenomatous polyposis
Ricardo G Correa et al.
Oncotarget, 5(6), 1666-1682 (2014-04-01)
Prostate cancer (PCa) is among the leading causes of cancer-related death in men. Androgen receptor (AR) signaling plays a seminal role in prostate development and homeostasis, and dysregulation of this pathway is intimately linked to prostate cancer pathogenesis and progression.
Damiano Carbonari et al.
Toxicology letters, 231(2), 205-212 (2014-06-27)
This study investigated the effect of polymorphic genes GSTT1, GSTM1, GSTA1, EHPX1, NQO1, CYP2E1, CYP1A and MPO on the urinary concentrations and ratio (R) of the benzene metabolites trans,trans-muconic acid (t,t-MA) and S-phenyl mercapturic acid (S-PMA) in 301 oil refinery
Ji Hyun Jang et al.
Basic research in cardiology, 110(3), 21-21 (2015-03-26)
Angiotensin II (Ang II), a potent precursor of hypertrophy and heart failure, upregulates neuronal nitric oxide synthase (nNOS or NOS1) in the myocardium. Here, we investigate the involvement of type 1 and 2 angiotensin receptors (AT1R and AT2R) and molecular
Shinji Sakuma et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(5), 1227-1236 (2015-03-01)
We are investigating an imaging agent that detects early-stage primary colorectal cancer on the mucosal surface in real time under colonoscopic observation. The imaging agent, which is named the nanobeacon, is fluorescent nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide). Its
Karine Nozeret et al.
Bioorganic & medicinal chemistry, 23(17), 5932-5945 (2015-07-21)
Synthetic minor groove-binding pyrrole-imidazole polyamides labeled by fluorophores are promising candidates for fluorescence imaging of double-stranded DNA in isolated chromosomes or fixed and living cells. We synthesized nine hairpin and two head-to-head tandem polyamides targeting repeated sequences from mouse major
Sarah R Catalano et al.
Parasitology, 142(8), 1066-1079 (2015-04-17)
Dicyemids, poorly known parasites of benthic cephalopods, are one of the few phyla in which mitochondrial (mt) genome architecture departs from the typical ~16 kb circular metazoan genome. In addition to a putative circular genome, a series of mt minicircles
Zachary D Abbott et al.
mBio, 6(3), e00595-e00595 (2015-06-11)
Critical to microbial versatility is the capacity to express the cohort of genes that increase fitness in different environments. Legionella pneumophila occupies extensive ecological space that includes diverse protists, pond water, engineered water systems, and mammalian lung macrophages. One mechanism
Anna Smolira et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1811-1816 (2015-09-04)
The PR-39 porcine cathelicidin occurs naturally in animal neutrophils. Its main function is antimicrobial activity, which potentially can be used in antibiotic treatments in veterinary medicine. Investigations concerning such a use require the detection and quantification of PR-39 in a
Andrés A Ojanguren-Affilastro et al.
Molecular phylogenetics and evolution, 94(Pt A), 159-170 (2015-09-01)
A phylogenetic analysis of the scorpion genus Brachistosternus Pocock, 1893 (Bothriuridae Simon, 1880) is presented, based on a dataset including 41 of the 43 described species and five outgroups, 116 morphological characters and more than 4150 base-pairs of DNA sequence
Laura Manelyte et al.
PLoS genetics, 10(3), e1004157-e1004157 (2014-03-22)
Active and repressed ribosomal RNA (rRNA) genes are characterised by specific epigenetic marks and differentially positioned nucleosomes at their promoters. Repression of the rRNA genes requires a non-coding RNA (pRNA) and the presence of the nucleolar remodeling complex (NoRC). ATP-dependent
Jaroslav Malina et al.
Dalton transactions (Cambridge, England : 2003), 44(33), 14656-14665 (2015-07-28)
Bulged structures have been identified in nucleic acids and have been shown to be linked to biomolecular processes involved in numerous diseases. Thus, chemical agents with affinity for bulged nucleic acids are of general biological significance. Herein, the mechanism of
Rachel M Smith et al.
Nucleic acids research, 42(9), 5809-5822 (2014-03-19)
Type II restriction-modification systems cleave and methylate DNA at specific sequences. However, the Type IIB systems look more like Type I than conventional Type II schemes as they employ the same protein for both restriction and modification and for DNA
Thomas Walzthoeni et al.
Nature methods, 12(12), 1185-1190 (2015-10-27)
Chemical cross-linking in combination with mass spectrometry generates distance restraints of amino acid pairs in close proximity on the surface of native proteins and protein complexes. In this study we used quantitative mass spectrometry and chemical cross-linking to quantify differences
Francisco Les et al.
Food & function, 6(6), 2049-2057 (2015-06-02)
Pomegranate juice and related products have long been used either in traditional medicine or as nutritional supplements claiming beneficial effects. Although there are several studies on this food plant, only a few studies have been performed with pomegranate juice or
Roopali Saxena et al.
Biochimica et biophysica acta, 1848(8), 1699-1705 (2015-05-13)
The function of membrane receptors in the nervous system depends on physicochemical characteristics of neuronal membranes such as membrane order and phase. In this work, we have monitored the changes in hippocampal membrane order and related parameters by cholesterol and
Franco A Rossato et al.
PloS one, 9(6), e101060-e101060 (2014-06-26)
The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in
Song-sheng Shi et al.
Journal of molecular neuroscience : MN, 57(4), 538-545 (2015-09-08)
Our previous studies demonstrated that propofol protects rat brain against focal cerebral ischemia. However, whether propofol attenuates early brain injury after subarachnoid hemorrhage in rats remains unknown until now. The present study was performed to evaluate the effect of propofol
Monika Hartmann et al.
The Journal of biological chemistry, 290(28), 17041-17054 (2015-05-01)
Ectodomain shedding of transmembrane precursor proteins generates numerous life-essential molecules, such as epidermal growth factor receptor ligands. This cleavage not only releases the regulatory growth factor, but it is also the required first step for the subsequent processing by γ-secretase
Lijun Zhu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(7), 977-983 (2015-04-10)
Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate the in vitro UDP-glucuronosyltransferase (UGT) metabolism
Hüseyin Tuncay et al.
Nature communications, 6, 8128-8128 (2015-08-27)
Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The contribution of cell adhesion molecules to the cortical localization of the dynein-dynactin complex is poorly understood. Here
Yujia Sun et al.
Gene, 563(2), 136-141 (2015-03-17)
The aim of this study was to examine the association of cofilin2 (CFL2) gene polymorphisms with growth traits in Chinese Qinchuan cattle. Three single nucleotide polymorphisms (SNPs) were identified in the bovine CFL2 gene using DNA sequencing and (forced) PCR-RFLP
L Liu et al.
Poultry science, 94(9), 2221-2227 (2015-07-19)
The present study was conducted with broiler chicks exposed to dexamethasone (DEX) to explore its effects on hypothalamic target of rapamycin (TOR) signaling and regulating appetite in diets containing different energy levels. At 5 d age, 48 chicks were divided
Benjamin Rothé et al.
Nucleic acids research, 42(16), 10731-10747 (2014-08-30)
Biogenesis of eukaryotic box C/D small nucleolar ribonucleoprotein particles (C/D snoRNPs) involves conserved trans-acting factors, which are proposed to facilitate the assembly of the core proteins Snu13p/15.5K, Nop58p/NOP58, Nop56p/NOP56 and Nop1p/Fibrillarin on box C/D small nucleolar RNAs (C/D snoRNAs). In
Pui-Mun Wong et al.
Nature communications, 6, 8048-8048 (2015-08-28)
Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation is that amino acid starvation triggers more rapid autophagy than pharmacological inhibition of mTORC1
Rubén Cereijo et al.
PloS one, 10(8), e0136571-e0136571 (2015-08-26)
Highly active antiretroviral therapy has remarkably improved quality of life of HIV-1-infected patients. However, this treatment has been associated with the so-called lipodystrophic syndrome, which conveys a number of adverse metabolic effects and morphological alterations. Among them, lipoatrophy of subcutaneous
Sarah Huet et al.
Genes, chromosomes & cancer, 54(10), 595-605 (2015-08-08)
We report five chronic myeloid leukaemia (CML) patients in whom we identified and characterized undescribed BCR-ABL1 fusion transcripts. We investigated the precise features of the molecular rearrangements and the minimal residual disease follow-up for these five patients. Three resulted from
Nedim Mutlu et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 128(9), 1791-1798 (2015-06-04)
We developed highly reliable co-dominant SCAR markers linked to the Frl gene. FORL testing is difficult. The marker is expected to be quickly adapted for MAS by tomato breeders. Fusarium oxysporum f. sp. radicis-lycopersici causes Fusarium crown and root rot
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