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Srinivasa R Penumutchu et al.
PloS one, 9(8), e103947-e103947 (2014-08-02)
The S100P protein is a member of the S100 family of calcium-binding proteins and possesses both intracellular and extracellular functions. Extracellular S100P binds to the cell surface receptor for advanced glycation end products (RAGE) and activates its downstream signaling cascade
Satoru Takanashi et al.
Veterinary research, 46, 80-80 (2015-07-15)
Cyclophilin A (CyPA) was originally discovered in bovine thymocytes as a cytosolic binding protein of the immunosuppressive drug cyclosporine A. Recent studies have revealed that in mice and humans, CyPA is secreted from cells in injured or infected tissues and
Chrissy M Leopold Wager et al.
Infection and immunity, 83(12), 4513-4527 (2015-09-10)
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an opportunistic fungal pathogen that primarily affects AIDS patients and patients undergoing immunosuppressive therapy. In immunocompromised individuals, C. neoformans can lead to life-threatening meningoencephalitis. Studies using a virulent strain of C.
Jill J Severson et al.
Cancer immunology research, 3(6), 620-630 (2015-02-24)
Regional metastatic differentiated thyroid cancer (mDTC) provides a unique model in which to study the tumor-immune interface. These lymph node metastases persist for years, generally without progression to distant metastases. Although the immune system likely impedes disease progression, it is
Y Yin et al.
Letters in applied microbiology, 61(6), 580-587 (2015-09-24)
(+)-Terrein shows multiple bioactivities, however, its mass production is a big challenge. Aspergillus terreus strain PF26 derived from South China Sea sponge Phakellia fusca has been cultured to produce (+)-terrein successfully, but artificial sea water (ASW) of high salinity used
Rainer Nikolay et al.
Nucleic acids research, 42(12), e100-e100 (2014-05-06)
While the structure of mature ribosomes is analyzed in atomic detail considerably less is known about their assembly process in living cells. This is mainly due to technical and conceptual hurdles. To analyze ribosome assembly in vivo, we designed and
F Vela-Soria et al.
Talanta, 129, 209-218 (2014-08-17)
The population is continuously exposed to endocrine disrupting chemicals (EDCs). This has influenced an increase in diseases and syndromes that are more frequent nowadays. Therefore, it is necessary to develop new analytical procedures to evaluate the exposure with the ultimate
So-Youn Min et al.
Journal of inflammation (London, England), 12, 53-53 (2015-09-18)
The activity of one of the major catechins in Green Tea, the polyphenol (-)-epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits. Recent studies suggest that EGCG can modulate both the innate and adaptive arms of the
Isabel Fernández de Castro et al.
The Journal of cell biology, 219(7) (2020-05-02)
Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses that replicate in cytoplasmic membranous organelles called viral inclusions (VIs) where progeny virions are assembled. To better understand cellular routes of nonlytic reovirus exit, we imaged sites of virus egress in infected, nonpolarized human
Caroline Park et al.
Nature communications, 6, 6823-6823 (2015-04-17)
Chaperone-mediated autophagy (CMA) is activated in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in disease and ageing. Here, we report that
Yuko Ishida et al.
International journal of legal medicine, 129(5), 1049-1054 (2015-04-08)
Endothelial progenitor cells (EPCs), a newly identified cell type, are bone marrow-derived progenitor cells that co-express stem cell markers and vascular endothelial growth factor (VEGF) receptor (Flk-1). In this study, a double-color immunofluorescence analysis was carried out using anti-CD34 and
Ke Chen et al.
Scientific reports, 5, 11909-11909 (2015-07-08)
Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetric and abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely unknown. We report here that miR-125a-3p and miR-483-5p are upregulated in the SAT of MSL patients
Allison Sang et al.
PloS one, 9(8), e102151-e102151 (2014-08-06)
The breakdown in tolerance of autoreactive B cells in the lupus-prone NZM2410-derived B6.Sle1.Sle2.Sle3 (TC) mice results in the secretion of autoantibodies. TC dendritic cells (DCs) enhance B cell proliferation and antibody secretion in a cytokine-dependent manner. However, the specific cytokine
Jeremy C McIntyre et al.
Journal of cell science, 128(10), 1934-1945 (2015-04-25)
Cilia are evolutionarily conserved organelles found on many mammalian cell types, including neuronal populations. Although neuronal cilia, including those on olfactory sensory neurons (OSNs), are often delineated by localization of adenylyl cyclase 3 (AC3, also known as ADCY3), the mechanisms
Sabine A F Jégouzo et al.
The Journal of biological chemistry, 290(27), 16759-16771 (2015-05-23)
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the receptor are not
Magdalena Jarosz-Biej et al.
Archivum immunologiae et therapiae experimentalis, 63(6), 451-464 (2015-03-25)
Tumor progression depends on tumor milieu, which influences neovasculature formation and immunosuppression. Combining immunotherapy with antiangiogenic/antivascular therapy might be an effective therapeutic approach. The aim of our study was to elaborate an anticancer therapeutic strategy based on the induction of
Sukhwan Yoon et al.
Applied and environmental microbiology, 81(10), 3510-3517 (2015-03-15)
Shewanella loihica strain PV-4 harbors both a functional denitrification (NO3 (-)→N2) and a respiratory ammonification (NO3 (-)→NH4 (+)) pathway. Batch and chemostat experiments revealed that NO2 (-) affects pathway selection and the formation of reduced products. Strain PV-4 cells grown
Maria C Whelan et al.
PloS one, 9(5), e97602-e97602 (2014-05-17)
Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage. We investigated the utilisation of regulatory
Yang Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(34), 12516-12521 (2014-08-13)
Middle East respiratory syndrome coronavirus (MERS-CoV) currently spreads in humans and causes ∼ 36% fatality in infected patients. Believed to have originated from bats, MERS-CoV is genetically related to bat coronaviruses HKU4 and HKU5. To understand how bat coronaviruses transmit
Nilufar Mohebbi et al.
PloS one, 8(1), e55286-e55286 (2013-02-06)
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate. In the collecting duct, the regulated fine-tuning of salt and acid-base homeostasis is achieved by a series of
Luisa Islas et al.
International journal of pharmaceutics, 488(1-2), 20-28 (2015-04-22)
Acrylic acid (AAc) and poly(ethylene glycol) methacrylate (PEGMA) were singly and dually grafted onto poly(vinyl chloride) (PVC) urinary catheters with the aim of preventing biofouling by endowing the catheters with the ability to load and release antimicrobial agents and to
Effat Alizadeh et al.
Chemical biology & drug design, 85(3), 268-279 (2014-07-26)
MicroRNAs are small non-coding RNAs that regulate key processes of the stem cells. Although, microRNAs have emerged as powerful regulators of differentiation, few studies have been focused on the post-transcriptional regulation of hepatic differentiation in mesenchymal stem cells (MSCs) by
Fahad N Almajhdi et al.
PloS one, 9(11), e113461-e113461 (2014-11-26)
Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop
XiaoJun Zuo et al.
Water research, 80, 12-19 (2015-05-20)
Inorganic nitrogen species have three states including ammonia nitrogen (NH4(+)/NH3), nitrite (NO2(-)) and nitrate (NO3(-)) and are often found in the disinfection system. However, no available literature could be found on their role and fate in photocatalytic disinfection systems. In
Shuang-Bai Zhou et al.
Transplantation, 98(10), 1048-1055 (2014-11-19)
Unpredictable survival rate of transplanted fat is an obstacle in application of fat grafting. Although recent researches have suggested that adipose-derived stromal vascular fraction (SVF) could promote grafted fat survival, there has been seldom reports on tracing the dynamic change
Niels A J Cremers et al.
International journal of molecular sciences, 15(10), 17974-17999 (2014-10-10)
Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injury. Heme oxygenase (HO) generates the cytoprotective effector molecules biliverdin/bilirubin, carbon
Sergio C Nanita et al.
Analytica chimica acta, 768, 1-11 (2013-03-12)
A sample extraction and purification procedure that uses ammonium-salt-induced acetonitrile/water phase separation was developed and demonstrated to be compatible with the recently reported method for pesticide residue analysis based on fast extraction and dilution flow injection mass spectrometry (FED-FI-MS). The
Kari L Roberts et al.
Journal of virology, 89(3), 1537-1549 (2014-11-28)
In the extracellular environment, cell-free virions seek out naive host cells over long distances and between organisms. This is the primary mechanism of spread for most viruses. Here we provide evidence for an alternative pathway previously undescribed for orthomyxoviruses, whereby
Ruiping Zhou et al.
PloS one, 9(8), e104392-e104392 (2014-08-08)
Mesenchymal stem cells (MSCs) have exhibited therapeutic effects in multiple animal models so that are promising liver substitute for transplantation treatment of end-stage liver diseases. However, it has been shown that over-manipulation of these cells increased their tumorigenic potential, and
Francesca Veronesi et al.
Age (Dordrecht, Netherlands), 36(3), 9647-9647 (2014-04-02)
Osteoporosis due to estrogen deficiency is an increasing bone health issue worldwide: new strategies are being studied for regenerative medicine of bone pathologies in these patients. The most commonly used cells for tissue engineering therapy are the bone marrow mesenchymal
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