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Juan Tang et al.
Chemical communications (Cambridge, England), 49(15), 1530-1532 (2013-01-17)
Platinum-cerium oxide hybrid nanocatalysts (CeO(2)-Pt) were for the first time designed as bionanolabels for highly efficient electrochemical immunosensing of low-abundance proteins coupling nanocatalyst-based redox cycling with in situ signal amplification strategy.
G N Bowers et al.
Clinical chemistry, 26(6), 724-729 (1980-05-01)
We describe specifications for high-purity 4-nitrophenol, which is suitable for spectrophotometric standardization. Such a reference material is needed in clinical enzymology to establish the proper molar absorptivity of 4-nitrophenol under final reaction conditions, particularly for measuring alkaline phosphatase activity in
Vandana Bhalla et al.
Chemical communications (Cambridge, England), 48(97), 11862-11864 (2012-10-09)
Fluorescent nanoaggregates of pentacenequinone derivative serve as reactors for the preparation of palladium nanoparticles in aqueous medium. Further, the combination of catalytic quantities of palladium nanoparticles with NaBH(4) smoothly reduces 4-nitrophenol to 4-aminophenol in aqueous medium.
Stéphanie Romand et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 14-21 (2014-07-06)
A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated capillary in aqueous medium and
Diogo Robl et al.
Bioresource technology, 177, 247-254 (2014-12-17)
The aim of this study was to develop a bioprocess for the production of β-glucosidase and pectinase from the fungus Annulohypoxylon stygium DR47. Media optimization and bioreactor cultivation using citrus bagasse and soybean bran were explored and revealed a maximum
Yuri Park et al.
Journal of colloid and interface science, 406, 196-208 (2013-06-25)
Montmorillonite (MMT) was converted to organoclays by intercalation of cationic surfactants into its interlayer space. Two types of organoclays were prepared from different surfactants (DDTMA and DDDMA) at different surfactant loadings, and the structural changes in the clays investigated using
Minghuan Wang et al.
Nanoscale, 5(17), 7913-7919 (2013-07-16)
Herein, we report the preparation of poly (cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) nanotubes decorated with Ag nanoparticles (NPs). The PZS nanotubes have been synthesized firstly via an in situ template approach, and then Ag nanoparticles were prepared via in situ reduction of AgNO3
Charline Corre et al.
Environmental technology, 33(13-15), 1671-1676 (2012-09-20)
During biological degradation, such as biofiltration of air loaded with volatile organic compounds, the pollutant is passed through a bed packed with a solid medium acting as a biofilm support. To improve microorganism nutritional equilibrium and hence to enhance the
Gian Maria Pacifici
Early human development, 81(7), 573-581 (2005-07-13)
Sulfotransferase is an important enzyme family that catalyses the transfer of a sulfate group from a donor substrate, 3'-phosphoadenosine-5'-phosphosulphate (PAPS), to an acceptor substrate which may be a drug, a hormone or a neurotransmitter that possesses a hydroxy or an
Yanyan Song et al.
Molecular pharmaceutics, 11(7), 2250-2261 (2014-06-04)
A folate-decorated, disulfide-based cationic dextran conjugate having dextran as the main chain and disulfide-linked 1,4-bis(3-aminopropyl)piperazine (BAP) residues as the grafts was designed and successfully prepared as a multifunctional gene delivery vector for targeted gene delivery to ovarian cancer SKOV-3 cells
Mai Shimizu et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1103-1109 (2014-04-23)
Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their structures. Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes that catalyze the hydrolysis of drugs in the liver. Characterization of the enzyme(s) responsible for
Roberto Bravo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 820(2), 229-236 (2005-05-19)
We have developed a method to measure 12 urinary phenolic metabolites of pesticides or related chemicals. The target chemicals for our method are 2-isopropoxyphenol; 2,4-dichlorophenol; 2,5-dichlorophenol; carbofuranphenol; 2,4,5-trichlorophenol; 2,4,6-trichlorophenol; 3,5,6-trichloro-2-pyridinol; para-nitrophenol, ortho-phenylphenol, pentachlorophenol, 1-naphthol and 2-naphthol. The sample preparation involves
Chao Lu et al.
Journal of environmental management, 113, 1-6 (2012-09-13)
Various metal ions are present in industrial wastewater. In this study, the role of Cu(2+) in pollutant degradation by laccase and the effect of common metal ions such as Na(+), K(+), Ca(2+), Mg(2+), Zn(2+), Hg(2+), Mn(2+), Fe(2+), Co(2+), Ni(2+), Fe(3+)
Kuan-I Chen et al.
Journal of agricultural and food chemistry, 60(51), 12540-12546 (2012-11-30)
A catalytic system for deglycosylation of isoflavone in black soybean milk was established. β-Glucosidase which was covalently immobilized onto the glass microspheres exhibited a significant efficiency for the conversion of pNPG to p-nitrophenol over other carriers. The optimum temperature for
Anna I Astashkina et al.
Biomaterials, 35(24), 6323-6331 (2014-05-13)
Nanocarriers and nanoparticles remain an intense pharmaceutical and medical imaging technology interest. Their entry into clinical use is hampered by the lack of reliable in vitro models that accurately predict in vivo toxicity. This study evaluates a 3-D kidney organoid
Harald P Hoensch et al.
World journal of gastroenterology, 19(36), 6020-6025 (2013-10-10)
To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds. We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase (UGT) and the cytosomal glutathione S-transferase (GST) in the uninvolved mucosa of the colon
Rui M F Bezerra et al.
Computer methods and programs in biomedicine, 109(1), 26-31 (2012-10-02)
Enzyme kinetic parameters are usually determined from initial rates nevertheless, laboratory instruments only measure substrate or product concentration versus reaction time (progress curves). To overcome this problem we present a methodology which uses integrated models based on Michaelis-Menten equation. The
Olga E Petrova et al.
Journal of bacteriology, 197(1), 174-187 (2014-10-22)
Biofilm dispersion is a highly regulated process that allows biofilm bacteria to respond to changing environmental conditions and to disseminate to new locations. The dispersion of biofilms formed by the opportunistic pathogen Pseudomonas aeruginosa is known to require a number
Sabrina Ehnert et al.
Experimental cell research, 332(2), 247-258 (2015-01-06)
Type 2 diabetes mellitus (T2DM) is one of the most frequent metabolic disorders in industrialized countries. Among other complications, T2DM patients have an increased fracture risk and delayed fracture healing. We have demonstrated that supraphysiological glucose and insulin levels inhibit
R J Anderson et al.
The Journal of laboratory and clinical medicine, 118(5), 500-509 (1991-11-01)
Phenol sulfotransferases (PSTs) catalyze the sulfate conjugation of catecholamines and a variety of phenolic compounds. Thermolabile and thermostable forms of PST exist in human tissue. Blood component thermostable PST activities have proved useful as measures of the enzyme activities in
Kosuke Sato et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(13), 5034-5040 (2015-02-14)
In biomineralization, acidic macromolecules play important roles for the growth control of crystals through a specific interaction. Inspired by this interaction, we report on an application of the hierarchical structures in CaCO3 biominerals to a stationary phase of chromatography. The
Kaila M Pianalto et al.
Toxicology letters, 223(2), 221-227 (2013-09-12)
CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol). The dose response of DNA and protein adducts derived from BD metabolites increases linearly at low BD exposures and then saturates at higher exposures
Joon Suk Oh et al.
Macromolecular rapid communications, 34(6), 504-510 (2013-01-29)
Polyglycidyl methacrylate (PGMA) microspheres, crosslinked and surface-functionalized by amine, can be used as a solid-state template for the synthesis of gold (Au) crystals in the forms of either nanoparticles (NPs) or plates. It is discovered that the polymer microsphere acts
Fang-Tian Xu et al.
American journal of translational research, 7(2), 257-270 (2015-04-23)
To investigate whether activated autologous platelet-rich plasma (PRP) can promote proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs) in vitro. hASCs were isolated from lipo-aspirates, and characterized by specific cell markers and multilineage differentiation capacity after culturing to
A Mitrofanova et al.
Nature communications, 10(1), 2692-2692 (2019-06-21)
Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by
Jin Goo Kim et al.
Small (Weinheim an der Bergstrasse, Germany), 11(16), 1930-1938 (2014-12-17)
As an effort to develop a simple and versatile synthetic strategy that contributes to the evolution of hollow nanostructures with increasing complexity and functionality, this research is devoted to study the hollow transformation within a nanosized solid matrix. Through an
T Osnes et al.
Scandinavian journal of clinical and laboratory investigation, 57(4), 307-315 (1997-07-01)
beta-Glucuronidase of human or bacterial origin may deconjugate bilirubin diglucuronide, causing pigment gallstones. Intrinsic interference by biliary compounds must be minimized for accurate assay of beta-glucuronidase. We report a modified ion-pair extraction of interfering substances by tetrahexylammonium chloride (THAC) in
Masashi Honma et al.
Journal of bone and mineral metabolism, 33(1), 73-84 (2014-01-02)
Recent studies have revealed that osteocytes play multiple important physiological roles. To analyze osteocyte functions in detail, an in vitro experimental system for primary osteocytes would be useful. Unfortunately, osteocytes tend to dedifferentiate and acquire osteoblast-like features even when the
G M Pacifici et al.
British journal of clinical pharmacology, 36(6), 593-597 (1993-12-01)
1 Phenol- and catechol- sulphotransferase activities were measured with p-nitrophenol and dopamine as substrates in platelets obtained from 100 newborns and 100 healthy adults. 2 Mean +/- (s.d.) estimates of catechol sulphotransferase activity were 7.07 +/- 5.93 (adult) and 13.3
Yunqing Zhu et al.
ACS nano, 8(5), 5022-5031 (2014-04-09)
Homopolymers have been considered as a nonideal building block for creating well-defined nanostructures due to their fuzzy boundary between hydrophobic and hydrophilic moieties. However, this unique fuzzy boundary may provide some opportunities for fabricating functional nanomaterials. Presented in this paper
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