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110086

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Shuai Zhang et al.
Analytical and bioanalytical chemistry, 407(30), 8971-8977 (2015-10-03)
Reliably detecting nitrofurazone (NFZ) residues in farmed crab and shrimp was previously hindered by lack of appropriately specific analytical methodology. Parent NFZ rapidly breaks down in meat, and the commonly used side-chain metabolite, semicarbazide (SEM), is non-specific as it occurs...
Amy Wong et al.
Journal of lipid research, 55(9), 1902-1913 (2014-07-27)
We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a defined time between negative and positive...
Daxin Chen et al.
Molecules (Basel, Switzerland), 20(10), 18597-18619 (2015-10-17)
Shexiang Tongxin dropping pill (STP) is a traditional Chinese medicine formula that consists of total saponins of ginseng, synthetic Calculus bovis, bear gall, Venenum bufonis, borneol and Salvia miltiorrhiza. STP has been widely used in China and Southeast Asia for...
Xiaobai Li et al.
International journal of molecular sciences, 15(11), 19877-19897 (2014-11-05)
The labellum in orchids shares homology with the inner lateral petals of the flower. The labellum is a modified petal and often distinguished from other petals and sepals due to its large size and irregular shape. Herein, we combined two-dimensional...
Panagiota Nikolaou et al.
Journal of pharmaceutical and biomedical analysis, 102, 25-32 (2014-09-23)
A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extraction (SPE) procedure using HF Bond Elut C18 columns followed by derivatization using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MTBSTFA)...
Che-Fan Huang et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 114-119 (2015-01-06)
Protein oxidation by reactive oxygen species has been associated with aging and neurodegenerative disorders, and histidine is one of the major oxidation targets due to its metal-chelating property and susceptibility to metal-catalyzed oxidation. 2-Oxohistidine, the major product of histidine oxidation...
Amrita K Cheema et al.
Journal of proteome research, 13(6), 3065-3074 (2014-05-16)
Although radiation-induced tissue-specific injury is well documented, the underlying molecular changes resulting in organ dysfunction and the consequences thereof on overall metabolism and physiology have not been elucidated. We previously reported the generation and characterization of a transgenic mouse strain...
Brian Chapron et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 18(1), 101-111 (2015-04-17)
Telaprevir inhibits CYP3A resulting in drug-drug interactions (DDI) of unprecedented magnitude. We investigated the mechanisms by which telaprevir inhibits the oxidation of midazolam and tacrolimus in human liver microsomes (HLM). We performed a static mechanistic DDI prediction to evaluate whether...
Christine C Siska et al.
Journal of pharmaceutical sciences, 104(2), 447-456 (2014-09-10)
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of mAb formulations containing PS20, small clouds of particles were observed in solutions stored in vials. The degree of particle formation was dependent on...
Heng Zhang et al.
European journal of medicinal chemistry, 89, 524-539 (2014-12-03)
We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity...
Emily E Woodward et al.
Journal of environmental quality, 43(6), 1933-1941 (2015-01-21)
The increase in endocrine-disrupting compounds in the environment has generated research focused on the behavior of these compounds in natural soil and water ecosystems. To understand how estrogens behave in the soil environment as a result of 25+ yr of...
Andreas Bornø et al.
Journal of mass spectrometry : JMS, 49(10), 980-988 (2014-10-11)
The present study describes a new liquid chromatography tandem mass spectrometry method for high-throughput quantification of glucose and glycerol in human plasma using stable isotopically labeled internal standards and is suitable for simultaneous measurements of glucose and glycerol enrichments in...
Mei Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 8-15 (2015-11-01)
A rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method was developed and validated for simultaneous quantification of simvastatin (SV), its metabolite simvastatin hydroxy acid (SVA) and berberine (BBR) in rat plasma. Separation was performed on Poroshell 120 EC-C18...
Jan Soukup et al.
Journal of chromatography. A, 1374, 102-111 (2014-12-30)
Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl...
Chang-Er Chen et al.
Environment international, 85, 284-291 (2015-10-10)
The occurrence of antibiotics in the environment has raised much concern in recent years. Understanding their release, fate and behaviour in the environment is vital to assess potential risks. In this study, a novel passive water sampler - diffusion gradients...
Luc Alexis Leuthold et al.
Analytical chemistry, 87(4), 2068-2071 (2015-01-22)
Hematocrit (Hct) is one of the most critical issues associated with the bioanalytical methods used for dried blood spot (DBS) sample analysis. Because Hct determines the viscosity of blood, it may affect the spreading of blood onto the filter paper....
Mei-Ying Liu et al.
Molecules (Basel, Switzerland), 20(10), 18967-18987 (2015-10-23)
Grapevine training systems determine the suitability for grape varieties in a specific growing region. We evaluated the influence of three training systems, Single Guyot (SG), Spur-pruned Vertical Shoot-Positioned (VSP), and Four-Arm Kniffin (4AK), on the performance of grapes and vines...
Susana Sadler Simões et al.
Forensic science international, 243, 117-125 (2014-08-16)
An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to extraction the samples were subjected...
David J Clark et al.
Theranostics, 6(1), 65-77 (2016-01-02)
Protein glycosylation plays a fundamental role in a multitude of biological processes, and the associated aberrant expression of glycoproteins in cancer has made them attractive biomarkers and therapeutic targets. In this study, we examined differentially expressed glycoproteins in cell lines...
Balázs Bobály et al.
Journal of chromatographic science, 53(7), 1078-1083 (2014-12-17)
It was found that recoveries of proteins depend on trifluoroacetic acid concentration in the mobile phase and showed maximum in the range of 0.01-0.1 v/v%. Transferrin and lysozyme were used to evaluate the recoveries of proteins from dedicated reversed-phase columns....
A Vinayagam et al.
Indian journal of pharmaceutical sciences, 77(1), 91-95 (2015-03-15)
Four major compounds were separated and identified from the methanol extracts of Nerium indicum flowers (Arali) using HPLC and mass spectral data. Through mass data, the chemical structures were elucidated as: trans5-O-caffeoylquinic acid (1), quercetin-3-O- rutinoside (2), luteolin-5-O-rutinoside (3) and...
Zbynek Dzuman et al.
Analytica chimica acta, 863, 29-40 (2015-03-04)
A new reliable and highly sensitive method based on high performance liquid chromatographic (HPLC) separation and high resolution tandem mass spectrometric detection (HRMS/MS) has been developed and validated for determination of 323 pesticide residues, 55 mycotoxins, and 11 plant toxins...
Martin Mangstl et al.
Dalton transactions (Cambridge, England : 2003), 43(26), 10033-10039 (2014-05-29)
A new synthesis route for phosphates in an organic solvent at low temperatures is presented. The synthesis was done by dispersing a nitrate salt and phosphorus pentoxide in dimethyl sulfoxide. The synthesis can be performed under water-free conditions and yielded...
Roberta Jeane B Jorge et al.
Journal of proteomics, 114, 93-114 (2014-12-03)
The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a...
Boning Wu et al.
The journal of physical chemistry. B, 119(46), 14790-14799 (2015-10-27)
Ionic liquids with electron-donating anions are used to investigate rates and mechanisms of photoinduced bimolecular electron transfer to the photoexcited acceptor 9,10-dicyanoanthracene (9,10-DCNA). The set of five cyano anion ILs studied comprises the 1-ethyl-3-methylimidazolium cation paired with each of these...
Lauriane Goldwirt et al.
Journal of neuro-oncology, 122(2), 273-281 (2015-03-22)
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnosed GBM...
Srinivas Rao Chennamaneni et al.
Pharmaceutical research, 31(11), 3179-3190 (2014-06-21)
To advance therapy for the treatment of concurrent uveitis and post-cataract surgical inflammation; we evaluated pharmacokinetics and pharmacodynamics of Bioerodible Dexamethasone Implant (BDI) containing 0.3 mg of dexamethasone (DXM) in Concanavalin A (Con A) induced uveitis followed by phacoemulsification in...
Liyun Ma et al.
Journal of separation science, 38(7), 1082-1089 (2015-02-03)
In the present study, one of the new generation of host molecules, cucurbit(6)uril (CB(6)), was immobilized onto silica (CB(6)/SiO2 ) by a sol-gel approach. CB(6)/SiO2 was characterized by NMR spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and elemental analysis. It...
Li-Ling Yeap et al.
PloS one, 9(11), e111544-e111544 (2014-11-07)
A simple liquid chromatography tandem mass spectrometry method was developed and validated according to the guidelines of the US Food and Drug Administration and the European Medicines Agency for a simultaneous quantification of levetiracetam (LEV) and its metabolite, UCB L057...
Christian Lanshoeft et al.
Analytical and bioanalytical chemistry, 406(22), 5413-5423 (2014-06-25)
A sensitive and ultra-fast method utilizing the laser diode thermal desorption ion source using atmospheric pressure chemical ionization coupled to tandem mass spectrometry (LDTD-APCI-MS/MS) was developed for the quantitative analysis of BKM120, an investigational anticancer drug in human plasma. Samples...
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