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H Veulemans et al.
British journal of industrial medicine, 50(1), 71-78 (1993-01-01)
A case-control study was conducted among first time patients at a clinic for reproductive disorders. The study group consisted of 1019 cases, defined as patients diagnosed infertile or subfertile on the basis of a spermiogram and 475 controls who were
Nanqin Li et al.
Journal of analytical toxicology, 30(4), 252-257 (2006-06-29)
Analysis of alkoxyacetic acids has received considerable research interest in toxicology because these compounds have been reported as metabolites and biomarkers of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers. This paper describes
Hong Soon Choi et al.
Journal of occupational health, 46(4), 260-265 (2004-08-17)
Alkyl cellosolves include ethylene glycol monomethylether, ethylene glycol monoethylether, ethylene glycol monobuthylether. And their urine metabolites are methoxyacetic acid, ethoxyacetic acid and butoxyacetic acid. The current analytical method for urinary alkoxyacetic acid is liquid-liquid phase extraction. But the liquid-liquid phase
J Liesivuori et al.
Archives of toxicology, 73(4-5), 229-232 (1999-08-27)
Male Wistar rats were given ethanediol (9.4 g/l), 2-ethoxyethylacetate (5.4 g/l), 2-butoxyethylacetate (2.9 g/l) and 1,2-propanediol (40 g/l) respectively in their drinking water for 2 weeks. Urine was collected during the last 24 h of the exposure. There was a
Beata Starek-Świechowicz et al.
Pharmacological reports : PR, 64(1), 166-178 (2012-05-15)
Exposure to various ethylene glycol monoalkyl ethers (EGAEs) is known to result in hemolytic effect caused by their metabolites, appropriate alkoxyacetic acids, generated via both alcohol dehydrogenase and aldehyde dehydrogenase. It has been shown in many studies that administration of
Rui-Sheng Wang et al.
Industrial health, 42(4), 447-451 (2004-11-16)
Ethylene glycol monoethyl ether (EGEE) is a solvent commonly used in industry. To find the health effect of the solvent exposure in women, we did an investigation on 32 female workers exposed to EGEE in factories manufacturing photopolymer sensitization plate
Rui-Sheng Wang et al.
Industrial health, 44(4), 665-668 (2006-11-07)
Ethylene glycol monoethyl ether (EGEE) is known to have testicular toxicity. To elucidate whether EGEE has any effect on sperm motion, especially in the case of short time exposure, we conducted a series of in vivo experiments with rats, as
Reproductive toxicology. Ethoxyacetic acid.
Environmental health perspectives, 105 Suppl 1, 211-212 (1997-02-01)
D Groeseneken et al.
Toxicology letters, 41(1), 57-68 (1988-04-01)
Male rats were given a single oral dose of ethylene glycol monoethyl ether (EGEE), the dose ranging from plausible human exposures (0.5-1 mg/kg) to doses reported in the literature (100 mg/kg). Urinary excretion of ethoxyacetic acid (EAA) and its glycine
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(4), 417-424 (1999-06-22)
1. The pharmacokinetics of methoxyacetic acid (MAA) and ethoxyacetic acid (EAA) have been determined in the male and female rat following bolus intravenous administration at 100 mg/kg. The plasma-concentration data of MAA fitted well to a one-compartment model, and the
J C Hoflack et al.
Mutation research, 341(4), 281-287 (1995-02-01)
Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9
D Groeseneken et al.
International archives of occupational and environmental health, 61(4), 249-254 (1989-01-01)
A sensitive and specific method for the determination in urine of alkoxyacetic acids, the metabolites of ethylene glycol monoalkyl ethers, was developed by combining the advantages of two previously described methods. The acids were determined gas chromatographically as their pentafluorobenzylesters.
T Sakai et al.
International archives of occupational and environmental health, 64(7), 495-498 (1993-01-01)
In control subjects and workers exposed to glycol ethers and their acetates, we determined the urinary metabolites (three alkoxyacetic acids) by a simple and rapid method. Levels of urinary metabolites were significantly higher in the solvent workers than in the
H Veulemans et al.
Scandinavian journal of work, environment & health, 13(3), 239-242 (1987-06-01)
The urinary excretion of ethoxyacetic acid (EAA) was studied in a group of five women daily exposed to the ethyl ether of ethylene glycol (EGEE) and the ethyl ether of ethylene glycol acetate (EGEE-Ac) during 5 d of normal production
Sanne A B Hermsen et al.
Reproductive toxicology (Elmsford, N.Y.), 32(2), 245-252 (2011-05-31)
The zebrafish embryotoxicity test (ZET) is an alternative test to predict embryotoxicity of substances based on morphological assessment. Implementing transcriptomics may increase sensitivity and objectivity of the test system. We applied the category approach to compare effects of compounds from
B Söhnlein et al.
International archives of occupational and environmental health, 64(7), 479-484 (1993-01-01)
Two groups of workers occupationally exposed to glycol ethers in a varnish production plant or the ceramic industry were examined. For 19 persons the external and internal exposure was assessed on the Monday and Tuesday after an exposure-free weekend. In
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(12), 1237-1244 (1998-02-14)
1. The elimination of 2-methoxyethanol (2-ME) and its toxic metabolite methoxyacetic acid (MAA) was studied in the male and female rat. We also studied the elimination of ethoxyacetic acid (EAA), the toxic metabolite formed by 2-ethoxyethanol (2-EE). 2. The rate
T S Shih et al.
Occupational and environmental medicine, 56(7), 460-467 (1999-09-03)
To simplify the current preparation of samples, and to improve the specificity and reliability of the conventional analytical methods to measure urinary alkoxyacetic acids. Samples containing alkoxyacetic acids including methoxy, ethoxy, and butoxyacetic acids (MAA, EAA, and BAA) were acidified
W G Chung et al.
Toxicology letters, 104(1-2), 143-150 (1999-02-27)
Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the
Andrzej Starek et al.
Acta poloniae pharmaceutica, 63(2), 89-94 (2007-05-23)
Alkoxyacetic acids (AAAs) are known urinary metabolites of the corresponding ethylene glycol monoalkyl ethers with a wide range of industrial and domestic applications. Hemolysis is the principal toxic effect of AAAs in humans and animals. The mechanism of red-cell damage
D Groeseneken et al.
British journal of industrial medicine, 44(7), 488-493 (1987-07-01)
Urinary excretion of ethoxyacetic acid during and after exposure to ethylene glycol monoethyl ether acetate (EGEE-Ac) was followed up in ten healthy male volunteers. During exposure to EGEE-Ac, ethoxyacetic acid levels appeared with a half life of 2.3 +/- 0.1
Sanne A B Hermsen et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(3), 745-753 (2011-01-18)
The zebrafish embryotoxicity test (ZET) is a fast and simple method to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo. We developed a novel quantitative evaluation method to assess the development of the zebrafish
Jochem Louisse et al.
Toxicology and applied pharmacology, 245(2), 236-243 (2010-03-17)
Embryotoxicity of glycol ethers is caused by their alkoxyacetic acid metabolites, but the mechanism underlying the embryotoxicity of these acid metabolites is so far not known. The present study investigates a possible mechanism underlying the embryotoxicity of glycol ether alkoxyacetic
J M Ratcliffe et al.
British journal of industrial medicine, 46(6), 399-406 (1989-06-01)
To evaluate whether long term exposure to 2-ethoxyethanol (2EE) may affect semen quality, a cross sectional study was conducted among men exposed to 2EE used as a binder slurry in a metal castings process. Full shift breathing zone exposures to
L K Lowry et al.
International archives of occupational and environmental health, 65(1 Suppl), S47-S51 (1993-01-01)
A practical application of urinary 2-ethoxyacetic acid (EAA) to assess occupational exposure to 2-ethoxyethyl acetate (EGEE-Ac) during a large format silk-screening operation is described. Industrial hygiene air monitoring of employees of a silk-screen shop producing large aircraft interior panel coverings
L K Lowry
Toxicology, 47(1-2), 55-69 (1987-12-01)
Human exposure to chemicals in the workplace has traditionally been assessed by determining the concentration of an airborne chemical in the workroom air. More recently, biological monitoring has been used to assess worker uptake of chemicals by all routes of
Esther de Jong et al.
Toxicological sciences : an official journal of the Society of Toxicology, 110(1), 117-124 (2009-04-30)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within
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