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Diana A Papazova et al.
Disease models & mechanisms, 8(3), 281-293 (2015-01-31)
Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis to evaluate the efficacy of cell-based therapy in preclinical (animal) studies of CKD
Tzong-Hsi Lee et al.
Digestive diseases and sciences, 60(2), 454-457 (2014-09-13)
Previous studies demonstrated that the sensitivity of rapid urease test (RUT) for diagnosis of Helicobacter pylori infection decreased during peptic ulcer bleeding. We designed this study and tried to find a better method to improve the detection rate of H.
QingMing Kong et al.
Molecular bioSystems, 11(5), 1400-1409 (2015-03-31)
Artesunate (ART) has high prophylactic efficacy against Schistosoma japonicum infections and has been used to treat and prevent schistosomiasis in China since 1995. However, the molecular mechanism of ART's effects on S. japonicum remains unclear. Herein, we applied isobaric tagging
Dan N Wang et al.
Helicobacter, 20(2), 98-105 (2014-11-11)
The Helicobacter pylori is considered the important causative agent causing biliary diseases, but the H. pylori can be isolated from very few gallbladder specimens with diseases. We studied the formation of H. pylori L-forms in bile in vitro and isolated the H. pylori
Fruzsina K Johnson et al.
Obesity (Silver Spring, Md.), 23(2), 383-390 (2015-01-06)
This study investigated whether arginase contributes to endothelial dysfunction and hypertension in obese rats. Endothelial function and arginase expression were examined in skeletal muscle arterioles from lean and obese Zucker rats (ZRs). Arginase activity, arginine bioavailability, and blood pressure were
Dominik Büchi et al.
The international journal of esthetic dentistry, 9(2), 134-145 (2014-04-26)
This case report describes a minimally invasive step-by-step approach to treat a patient with amelogenesis imperfecta. This is a genetic developmental disorder of the dental enamel, which clinically manifests as white and dark discolorations of the teeth. The clinical examination
Dan Shen et al.
The New phytologist, 204(3), 577-594 (2014-08-19)
Verticillium longisporum, a soil-borne pathogenic fungus, causes vascular disease in oilseed rape (Brassica napus). We proposed that plant microRNAs (miRNAs) are involved in the plant-V. longisporum interaction. To identify oilseed rape miRNAs, we deep-sequenced two small RNA libraries made from
Ilaria Fiorentino et al.
Experimental cell research, 330(2), 240-247 (2014-09-24)
Nanoparticle (NPs) delivery systems in vivo promises to overcome many obstacles associated with the administration of drugs, vaccines, plasmid DNA and RNA materials, making the study of their cellular uptake a central issue in nanomedicine. The uptake of NPs may
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3205-3210 (2015-02-13)
The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures
M Ahmed Mesaik et al.
Journal of agricultural and food chemistry, 63(1), 177-184 (2014-12-17)
Recent evidence suggests an important role for natural honey in modulating immune response. To identify active components responsible, this study investigated the immunomodulatory properties of glycoproteins and glycopeptides fractionated from Ziziphus honey. Honey proteins/peptides were fractionated by size exclusion chromatography
Kehua Wang et al.
PloS one, 9(7), e102914-e102914 (2014-07-23)
Heat stress is a primary factor causing summer bentgrass decline. Changes in gene expression at the transcriptional and/or translational level are thought to be a fundamental mechanism in plant response to environmental stresses. Heat stress redirects protein synthesis in higher
Zhijing Tan et al.
Journal of proteome research, 14(4), 1968-1978 (2015-03-04)
Glycosylation has significant effects on protein function and cell metastasis, which are important in cancer progression. It is of great interest to identify site-specific glycosylation in search of potential cancer biomarkers. However, the abundance of glycopeptides is low compared to
Yi-Ren Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 150-162 (2014-04-23)
The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation
Tony Ly et al.
eLife, 4 (2015-01-03)
Previously, we analyzed protein abundance changes across a 'minimally perturbed' cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014). In this study, we compare data from elutriated cells
Christopher T Esapa et al.
PloS one, 10(4), e0122650-e0122650 (2015-04-11)
Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as
Zeyou Wang et al.
Oncotarget, 6(5), 3147-3164 (2015-01-22)
MicroRNA-381 (miR-381) is a highly expressed onco-miRNA that is involved in malignant progression and has been suggested to be a good target for glioblastoma multiforme (GBM) therapy. In this study, we employed two-dimensional fluorescence differential gel electrophoresis (2-D DIGE) and
Jing Yu et al.
Molecular bioSystems, 10(10), 2558-2566 (2014-07-12)
To understand the molecular mechanisms of idiopathic epiretinal membranes (iERMs), the vitreous proteomes of patients with iERMs were investigated. The vitreous proteome in patients with iERMs (n = 8) and donor samples (n = 8) was analysed using reversed phase
Lise Bankir et al.
Kidney international, 81(12), 1179-1198 (2012-03-30)
The mechanism by which urine is concentrated in the mammalian kidney remains incompletely understood. Urea is the dominant urinary osmole in most mammals and may be concentrated a 100-fold above its plasma level in humans and even more in rodents.
Mingliang Zhang et al.
Journal of chromatography. A, 1365, 148-155 (2014-09-25)
One-pot synthesis of surface-confined ionic liquid functionalized silica spheres was proposed using N-(3-aminopropyl)imidazole, γ-isopropyltriethoxysilane and 1-bromooctadecane as starting materials. The surface modification of the silica spheres was successful with a high surface density of octadecylimidazolium, enabling the utilization of this
Andrés Castellanos-Martín et al.
Genome biology, 16, 40-40 (2015-04-09)
An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels. Here, we present a
Yuh-Wen Chiu et al.
Journal of environmental biology, 35(4), 667-673 (2014-07-10)
The freshwater golden apple snail, Pomacea canaliculata, is one of the world's 100 worst invasive alien species. The snails' wide distribution, high abundance, and sensitivity to environmental pollution make them a potential bioindicator for environmental contamination. In this study, the
Joaquín Fernández-Irigoyen et al.
Molecular brain, 7, 83-83 (2014-11-20)
The basal ganglia (BG) are a complex network of subcortical nuclei involved in the coordination and integration of the motor activity. Although these independent anatomical structures are functionally related, the proteome present in each isolated nucleus remains largely unexplored. In
Qian Chen et al.
Journal of proteome research, 14(4), 1831-1842 (2015-03-03)
The menstrual cycle of the female uterus leads to periodic changes of the endometrium. These changes are important for developing the endometrial receptivity and for achieving competency of embryo implantation. However, the molecular events underlying the endometrial receptivity process remain
Christian Gebauer et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(10), 2094-2107 (2014-05-23)
The potential of platinum catalysts supported on pure, nitrogen-, or carbon-doped titania for application in the oxygen reduction reaction (ORR), as a cathode catalyst in polymer electrolyte membrane fuel cells, is investigated. The oxide supports are synthesized by using a
Luciana S Oliveira et al.
PloS one, 9(6), e98913-e98913 (2014-06-10)
C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in
Mari Akiyama
Analytical and bioanalytical chemistry, 406(24), 5805-5813 (2014-04-04)
Inspection of patient-derived cells used in transplantation is non-invasive. Therefore, proteomics analysis using supernatants of cells cultured before transplantation is informative. In order to investigate the cell niche of bovine periosteal cells, supernatants of these cultured cells were subjected to
Devendar Anumandla et al.
Organic letters, 16(19), 5112-5115 (2014-09-13)
Diamination of alkenes and dienes has found widespread use in the synthesis of biologically active target molecules. Although the 1,2-diamination of alkenes has been comprehensively explored, versatile methods that install higher order 1,n-diamine moieties (e.g., n = 3-5) are not
A Marechal et al.
Journal of chromatography. A, 1365, 140-147 (2014-09-25)
This paper presents a photografting process of monolithic silica capillary columns based on the ene-thiol click chemistry. This study is performed on a "generic" vinyl-functionalized silica monolith (Hmin 6±1μm). The photoclick reaction is investigated using different thiol monomers (octadecanethiol, cysteine
Frank Y Ma et al.
American journal of physiology. Renal physiology, 307(11), F1263-F1273 (2014-10-10)
Stress-activated kinases p38 MAPK and JNK promote renal fibrosis; however, how the pathways by which these kinases are activated in kidney disease remain poorly defined. Apoptosis signal-regulating kinase 1 (ASK1/MAPKKK5) is a member of the MAPKKK family that can induce
Keiichi Akasaka et al.
American journal of physiology. Lung cellular and molecular physiology, 308(2), L105-L117 (2014-11-16)
Whole-lung lavage (WLL) remains the standard therapy for pulmonary alveolar proteinosis (PAP), a process in which accumulated surfactants are washed out of the lung with 0.5-2.0 l of saline aliquots for 10-30 wash cycles. The method has been established empirically.
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