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Judyta Cielecka-Piontek et al.
Pharmaceutical development and technology, 20(2), 146-152 (2013-11-14)
The kinetic and thermodynamic parameters of degradation of clavulanate potassium in the solid state were studied by using a reversed phase high performance liquid chromatography (RP-HPLC) method. The degradation of clavulanate potassium was a first-order reaction depending on the substrate
K M Frankowski et al.
Journal of dairy science, 97(9), 5356-5370 (2014-07-16)
Many food companies are trying to limit the amount of sodium in their products. Permeate, the liquid remaining after whey or milk is ultrafiltered, has been suggested as a salt substitute. The objective of this study was to determine the
Ramesh B Badisa et al.
PloS one, 10(1), e0114285-e0114285 (2015-01-27)
Cocaine has a short half-life of only about an hour but its effects, predominantly on the central nervous system (CNS), are fairly long-lasting. Of all cells within the CNS, astrocytes may be the first to display cocaine toxicity owing to
Lucília Domingues et al.
Bioengineered bugs, 1(3), 164-171 (2011-02-18)
Lactose is an interesting carbon source for the production of several bio-products by fermentation, primarily because it is the major component of cheese whey, the main by-product of dairy activities. However, the microorganism more widely used in industrial fermentation processes
Alejandro J Cagnoni et al.
Organic & biomolecular chemistry, 11(33), 5500-5511 (2013-07-19)
We report here the synthesis of divalent ligands containing 3-deoxy-4-thiolactose. This thiodisaccharide has been synthesized using the Michael addition of β-1-thiogalactose to the α,β-unsaturated system of sugar-derived dihydropyranones, followed by the reduction of the remaining carbonyl group. We were able
David D L Minh et al.
Biophysical journal, 104(4), 873-883 (2013-02-28)
A new way to use wide-angle x-ray solution scattering to study protein-ligand binding is presented. First, scattering patterns are measured at different protein and ligand concentrations. Multivariate curve resolution based on singular value decomposition and global analysis is applied to
Juan G Osorio et al.
Drug development and industrial pharmacy, 39(9), 1464-1475 (2013-08-02)
Filling capsules with the right amount of powder ingredients is an important quality parameter. The purpose of this study was to develop effective laboratory methods for characterizing flow properties of pharmaceutical powder blends and correlating such properties to weight variability
Qikun Jiang et al.
Drug development and industrial pharmacy, 41(2), 201-206 (2013-12-27)
The aim of this study was to improve the oral bioavailability of spironolactone (SP). SP was adsorbed on the fumed silica using supercritical CO2 (scCO2) technology and further compressed into tablets. The morphology was observed by scanning electron microscopy (SEM)
Hirotsugu Hiramatsu et al.
Biochemistry, 52(13), 2371-2380 (2013-03-21)
The pH dependence of the β-galactoside binding activity of human galectin-1 (hGal-1) was investigated by fluorescence spectroscopy using lactose as a ligand. The obtained binding constant Kb was 2.94 ± 0.10 mM(-1) at pH 7.5. The Kb value decreased at
Meiyan Yang et al.
International journal of pharmaceutics, 475(1-2), 97-109 (2014-08-31)
The aim of the present work was to design a pH-modified solid dispersion (pH(M)-SD) that can improve the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti-prostate cancer drug. To select the appropriate acidifiers, a solubility test
Sharvil S Patil et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 43-50 (2014-12-03)
The current work was undertaken to assess suitability of liquid crystalline phase for engineering of lactose crystals and their utility as a carrier in dry powder inhalation formulations. Saturated lactose solution was poured in molten glyceryl monooleate which subsequently transformed
Uta Praekelt et al.
Journal of medical microbiology, 63(Pt 12), 1595-1607 (2014-09-19)
Enteropathogenic Escherichia coli (EPEC) are a major cause of infant diarrhoea in developing countries and a significant public health issue in industrialized countries. Currently there are no simple tests available for the diagnosis of EPEC. Serology of O-antigens is widely
Martin Andreas Wälti et al.
Journal of molecular biology, 379(1), 146-159 (2008-04-29)
Recent advances in genome sequencing efforts have revealed an abundance of novel putative lectins. Among these, many galectin-related proteins, characterized by many conserved residues but intriguingly lacking critical amino acids, have been found in all corners of the eukaryotic superkingdom.
Gisela A Weiss et al.
The British journal of nutrition, 111(9), 1602-1610 (2014-01-15)
The oligosaccharides 2-fucosyllactose and 3-fucosyllactose are major constituents of human breast milk but are not found in mouse milk. Milk oligosaccharides have a prebiotic action, thus affecting the colonisation of the infant intestine by microbiota. To determine the specific effect
Kwangkook Lee et al.
Biochemical and biophysical research communications, 446(2), 568-573 (2014-03-19)
Botulinum neurotoxins (BoNTs) are produced as progenitor toxin complexes (PTCs) by Clostridium botulinum. The PTCs are composed of BoNT and non-toxic neurotoxin-associated proteins (NAPs), which serve to protect and deliver BoNT through the gastrointestinal tract in food borne botulism. HA33
Thao T Le et al.
Food chemistry, 141(2), 1203-1210 (2013-06-26)
Lactosylation in stored milk powder was quantified by multiple reaction monitoring (MRM), a mass spectrometry-based quantification method. The MRM method was developed from a knowledge of peptide fragmentation. The neutral losses of 162Da (cleavage of galactose) and 216Da (the formation
Lubna Ahmed et al.
Food chemistry, 134(4), 2249-2256 (2013-02-28)
The effect of delactosed whey permeate (DWP) treatment on antioxidant and phyto-chemical components of canned Irish plum tomatoes were investigated. Tomatoes were sterilised for 5 min (F(0)) at 120 °C and stored for 6 months. The DWP treatment retained significantly
Grzegorz Garbacz et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 264-272 (2013-09-12)
Current compendial dissolution and disintegrating testing is unable to mimic physiological conditions affecting gastric drug release from immediate release dosage forms. In order to obtain more realistic data, a novel test setup was developed that we term a 'dynamic open
Kanako Moriyama et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1200-1211 (2014-09-30)
Galectins are a unique family of lectins bearing one or two carbohydrate recognition domains (CRDs) that have the ability to bind molecules with β-galactoside-containing carbohydrates. It has been shown that galectins regulate not only cell growth and differentiation but also
Ayşegül Karataş et al.
Acta poloniae pharmaceutica, 70(5), 883-897 (2013-10-24)
The aim of the study was to investigate the physical stability of the semi-solid dispersions into the hard gelatine capsules prepared with Gelucire 44/14, Labrasol and different additives such as microcrystalline cellulose (MCC), mannitol and lactose (alpha-monohydrate) used for enhancing
Takahiro Yonekawa et al.
Brain : a journal of neurology, 137(Pt 10), 2670-2679 (2014-07-27)
Patients with GNE myopathy, a progressive and debilitating disease caused by a genetic defect in sialic acid biosynthesis, rely on supportive care and eventually become wheelchair-bound. To elucidate whether GNE myopathy is treatable at a progressive stage of the disease
Hannah D Holscher et al.
The Journal of nutrition, 144(5), 586-591 (2014-02-28)
Stimulation of gastrointestinal tract maturation is 1 of the many benefits of human milk. Human milk oligosaccharides (HMOs) are abundant in human milk and are reported to promote enterocyte differentiation in vitro. The objective of this study was to assess
Min Liu et al.
Experimental and molecular pathology, 98(1), 18-26 (2014-12-03)
Lung cancer is one of the few human diseases for which the primary etiological agent, cigarette smoke (CS), has been described; however, the precise role of individual cigarette smoke toxicant in tumor development and progression remains to be elusive. The
Angela E Newton et al.
Food chemistry, 173, 1243-1249 (2014-12-04)
Food systems, such as cream and butter, have an emulsion or emulsion-like structure. When these food emulsions are heated to high temperatures to make products such as ghee, the Maillard reaction forms a range of volatile flavour compounds. The objective
Ilaria De Pasquale et al.
Applied and environmental microbiology, 80(14), 4085-4094 (2014-04-29)
Pyrosequencing of the 16S rRNA gene, community-level physiological profiles determined by the use of Biolog EcoPlates, and proteolysis analyses were used to characterize Canestrato Pugliese Protected Designation of Origin (PDO) cheese. The number of presumptive mesophilic lactococci in raw ewes'
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters
Pedro M R Guimarães et al.
Biotechnology advances, 28(3), 375-384 (2010-02-16)
Cheese whey, the main dairy by-product, is increasingly recognized as a source of many bioactive valuable compounds. Nevertheless, the most abundant component in whey is lactose (ca. 5% w/v), which represents a significant environmental problem. Due to the large lactose
Muireann Egan et al.
Applied and environmental microbiology, 80(14), 4414-4426 (2014-05-13)
Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study
Daniel García-Pérez et al.
Addiction biology, 20(1), 104-119 (2013-08-10)
Epigenetic changes such as microRNAs (miRs)/Ago2-induced gene silencing represent complex molecular signature that regulate cellular plasticity. Recent studies showed involvement of miRs and Ago2 in drug addiction. In this study, we show that changes in gene expression induced by morphine
Amada B Pucciarelli et al.
Revista Argentina de microbiologia, 46(4), 325-332 (2015-01-13)
Due to the interest in the production and trading of yateí (Tetragonisca angustula) honey in the province of Misiones, Argentina, in this work we assessed microbiological and physicochemical parameters in order to contribute to the elaboration of standards for quality
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