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Navid Adnani et al.
Marine drugs, 13(10), 6082-6098 (2015-09-26)
With respect to bacterial natural products, a significant outcome of the genomic era was that the biosynthetic potential in many microorganisms surpassed the number of compounds isolated under standard laboratory growth conditions, particularly among certain members in the phylum Actinobacteria.
John M Franck et al.
Progress in nuclear magnetic resonance spectroscopy, 74, 33-56 (2013-10-03)
Liquid state Overhauser effect Dynamic Nuclear Polarization (ODNP) has experienced a recent resurgence of interest. The ODNP technique described here relies on the double resonance of electron spin resonance (ESR) at the most common, i.e. X-band (∼10GHz), frequency and ¹H
Minoru Miyazato et al.
The Journal of urology, 194(3), 842-847 (2015-03-26)
We investigated the effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on the sneeze induced continence reflex and on bladder function in rats with cerebral infarction. Using urethane anesthesia the effect of duloxetine (1 mg/kg intravenously) on the amplitude
Daniel J O'Sullivan et al.
BMC microbiology, 15, 266-266 (2015-11-19)
The aim of this study was to employ high-throughput DNA sequencing to assess the incidence of bacteria with biogenic amine (BA; histamine and tyramine) producing potential from among 10 different cheeses varieties. To facilitate this, a diagnostic approach using degenerate
Sandeep Kumar et al.
Journal of nanoscience and nanotechnology, 14(6), 4331-4336 (2014-04-18)
Carbon nanotubes (CNTs) are attracting increasing research interest as promising adsorbents for harmful cations, anions, and other organic and inorganic impurities present in natural sources of water. This study examined the feasibility of removing Rhodamine B dye from aqueous solutions
Egor V Verbitskiy et al.
Journal of fluorescence, 25(3), 763-775 (2015-03-31)
Novel donor-π-acceptor dyes bearing the pyrimidine unit as an electron-withdrawing group have been synthesized by using combination of two processes, based on the microwave-assisted Suzuki cross-coupling reaction and nucleophilic aromatic substitution of hydrogen. Spectral properties of the obtained dyes in
Felix Grases et al.
The Journal of urology, 194(3), 812-819 (2015-03-31)
The main aim of the current study was to evaluate the effectiveness of mixtures of magnesium, citrate and phytate as calcium oxalate crystallization inhibitors. A turbidimetric assay in synthetic urine was performed to obtain induction times for calcium oxalate crystallization
Francisco J Rios et al.
The Journal of pharmacology and experimental therapeutics, 353(1), 27-34 (2015-01-27)
Hyperaldosteronism and hypertension were unexpected side effects observed in trials of torcetrapib, a cholesteryl ester-transfer protein (CETP) inhibitor that increases high-density lipoprotein. Given that CETP inhibitors are lipid soluble, accumulate in adipose tissue, and have binding sites for proteins involved
Obstetrics and gynecology, 123(4), 912-915 (2014-05-03)
Immersion in water has been suggested as a beneficial alternative for labor, or delivery, or both and over the past decades has gained popularity in many parts of world. Immersion in water during the first stage of labor may be
Shadab Faramarzi et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 70(3), 324-330 (2015-07-03)
In order to promote breeding programs and a full reintroduction into production of two local red-fleshed apple varieties grown in Bekran and Bastam (Iran), the evaluation of their antioxidant properties was of interest. LC-MS(n) based metabolic fingerprinting analyses were applied
Yunqing Tang et al.
Scientific reports, 5, 11073-11073 (2015-06-23)
Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe's resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between
Mary A Rodgers et al.
The Journal of experimental medicine, 211(7), 1333-1347 (2014-06-25)
Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in
Bo Zhang et al.
PloS one, 10(7), e0132700-e0132700 (2015-07-22)
The small heat shock protein (sHsp) family is thought to play an important role in protein refolding and signal transduction, and thereby protect organisms from stress. However little is known about sHsp function and conservation across phylogenies. In the current
Timothy Kernan et al.
Biotechnology and bioengineering, 113(1), 189-197 (2015-07-16)
There is growing interest in developing non-photosynthetic routes for the conversion of CO2 to fuels and chemicals. One underexplored approach is the transfer of energy to the metabolism of genetically modified chemolithoautotrophic bacteria. Acidithiobacillus ferrooxidans is an obligate chemolithoautotroph that
Fouzia Amamou et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 78, 177-184 (2015-01-27)
Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids
Elisa Ramos-Sevillano et al.
Infection and immunity, 83(2), 591-603 (2014-11-19)
The complement system is a key component of the host immune response for the recognition and clearance of Streptococcus pneumoniae. In this study, we demonstrate that the amidase LytA, the main pneumococcal autolysin, inhibits complement-mediated immunity independently of effects on
Pedro Linares-Clemente et al.
The Journal of physiology, 593(13), 2867-2888 (2015-05-20)
Neurotransmitter release requires a tight coupling between synaptic vesicle exocytosis and endocytosis with dynamin being a key protein in that process. We used imaging techniques to examine the time course of endocytosis at mouse motor nerve terminals expressing synaptopHluorin, a
Kamil Brzóska et al.
Radiation and environmental biophysics, 54(3), 353-363 (2015-05-15)
The most frequently used and the best established method of biological dosimetry at present is the dicentric chromosome assay, which is poorly suitable for a mass casualties scenario. This gives rise to the need for the development of new, high-throughput
A A Dutov et al.
Biomeditsinskaia khimiia, 59(5), 514-518 (2014-02-01)
Proposed modified HPLC method for determination of valproic acid in biological fluids. Created solid-phase extraction of valproic and heptanoic acids (internal standard, IS) on the cartridges packed hyper cross-linked polystyrene which maintain some tens extractions without losses of efficiency. Carboxylic
Petter Angell Olsen et al.
PloS one, 9(12), e115496-e115496 (2014-12-24)
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year survival rate of <5% and available treatments are only minimal effective. WNT/β-catenin signaling has been identified as one of 12 core signaling pathways that are commonly
Yael Jaldety et al.
Zygote (Cambridge, England), 23(5), 652-661 (2014-07-16)
Mammalian sperm acquire fertilization capacity after residing in the female reproductive tract for a few hours in a process called capacitation. Only capacitated sperm can bind the zona pellucida (ZP) of the egg and undergo the acrosome reaction, a process
Mette Kolpen et al.
International journal of medical microbiology : IJMM, 305(1), 1-10 (2014-12-03)
Chronic Pseudomonas aeruginosa lung infection is the most severe complication for cystic fibrosis (CF) patients. Infected endobronchial mucus of CF patients contains anaerobic zones mainly due to the respiratory burst of polymorphonuclear leukocytes. We have recently demonstrated ongoing denitrification in
T Gobbetti et al.
British journal of pharmacology, 172(3), 910-923 (2014-10-10)
Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n-3
Yuyi Zhou et al.
Scientific reports, 5, 13870-13870 (2015-09-09)
Coronatine (COR) is a phytotoxin produced by Pseudomonas syringae. Its structure is similar to Jasmonates, which play a number of diverse roles in plant defense. Both have the COI1 plant receptor, so coronatine can manipulate plant hormone signaling to access
Jacob M Vogan et al.
The Journal of biological chemistry, 290(35), 21320-21335 (2015-07-15)
Human telomerase acts on telomeres during the genome synthesis phase of the cell cycle, accompanied by its concentration in Cajal bodies and transient colocalization with telomeres. Whether the regulation of human telomerase holoenzyme assembly contributes to the cell cycle restriction
Radha Thyagarajan et al.
Autoimmunity, 48(5), 298-304 (2015-02-25)
The immunoglobulin isotype IgE is commonly associated with allergy. However, its involvement in autoimmune disease in general, and Type 1 diabetes (T1D) in particular, is still not completely clarified, nonetheless IgE has been observed in patients with T1D. In this
Barbara M Braunger et al.
Investigative ophthalmology & visual science, 55(11), 7499-7507 (2014-10-18)
To identify stem cells in the chamber angle of the monkey eye by detection of 5-bromo-2'-deoxyuridine (BrdU) long-term retention. Four cynomolgus monkeys were treated with BrdU via subcutaneous pumps for 4 weeks. The eyes of two animals were processed immediately
Oishi Sanyal et al.
Journal of nanoscience and nanotechnology, 14(3), 2178-2189 (2014-04-22)
Reverse osmosis (RO) and nanofiltration (NF) are the two dominant membrane separation processes responsible for ion rejection. While RO is highly efficient in removal of ions it needs a high operating pressure and offers very low selectivity between ions. Nanofiltration
Rongzeng Liu et al.
BMC biotechnology, 15, 50-50 (2015-06-10)
Plasmin is a serine protease that plays a critical role in fibrinolysis, which is a process that prevents blood clots from growing and becoming problematic. Recombinant human microplasminogen (rhμPlg) is a derivative of plasmin that solely consists of the catalytic
Lin Lin et al.
Protein & cell, 6(8), 575-588 (2015-04-29)
Human papillomaviruses (HPVs) including high-risk (HR) and low-risk (LR) subtypes have distinguishable variation on both genotypes and phenotypes. The co-infection of multiple HR-HPVs, headed by HPV16, is common in cervical cancer in female. Recently accumulating reports have focused on the
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