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Sung-Moo Kim et al.
Phytotherapy research : PTR, 29(11), 1828-1836 (2015-10-02)
Brassinin (BSN), a type of indole compound derived from cruciferous vegetables, has shown anti-cancer effects in cells and animals. Capsaicin (CAP), an alkaloid derived from the chilli pepper, is also of interest in for its reported efficacy against various malignancies.
Kihyun Pyun et al.
Pharmacology, biochemistry, and behavior, 124, 278-283 (2014-07-06)
Primary headache disorders, including migraine, are thought to be mediated by prolonged nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. Our past studies demonstrated that sigma-1 receptors (Sig-1R) facilitate spinal nociceptive transmission in
Francisco R Nieto et al.
Journal of natural products, 76(4), 737-740 (2013-04-02)
The effects of maslinic acid (1), a pentacyclic triterpenoid obtained from Olea europaea, were studied in several tests for nociception in mice. Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia.
Jason D Foss et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(2), R112-R122 (2014-11-21)
Renal denervation has been shown to lower arterial pressure in some hypertensive patients, yet it remains unclear whether this is due to ablation of afferent or efferent renal nerves. To investigate the role of afferent renal nerves in arterial pressure
Peng Wang et al.
Chinese journal of cancer, 34(4), 166-176 (2015-05-13)
Oncogenic activation of the K-ras gene occurs in >90% of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this malignancy. Increase of reactive oxygen species (ROS) has also been observed in a wide spectrum of cancers.
Yi Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14738-14748 (2013-09-13)
Spatial and temporal cues govern the genesis of a diverse array of neurons located in the dorsal spinal cord, including dI1-dI6, dIL(A), and dIL(B) subtypes, but their physiological functions are poorly understood. Here we generated a new line of conditional
Giovanni Appendino et al.
Bioorganic & medicinal chemistry letters, 20(1), 97-99 (2009-12-03)
The side chain benzylic methylene is a critical element for the vanilloid activity of resiniferatoxin (2a, RTX), and introduction of branching, oxygen functions, or isosteric substitution at this center proved detrimental, with a decrease of potency of 2-3 orders of
Felix W Leung
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 68, 171-179 (2014-06-20)
Laboratory studies support a role of capsaicin as an anti-obesity agent. Intestinal mucosal afferent nerves appear to play a role in controlling adipose tissue distribution between visceral and subcutaneous sites. Activation of the transient receptor potential vanilloid-1 channels by capsaicin
Youtian Hu et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(2), G149-G157 (2014-05-31)
Eosinophilic esophagitis (EoE) is characterized with eosinophils and mast cells predominated allergic inflammation in the esophagus and present with esophageal dysfunctions such as dysphagia, food impaction, and heartburn. However, the underlying mechanism of esophageal dysfunctions is unclear. This study aims
Yukiko Muroi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R1017-R1023 (2013-04-12)
Adeno-associated virus delivery systems and short hairpin RNA (shRNA) were used to selectively silence the voltage-gated sodium channel NaV 1.7 in the nodose ganglia of guinea pigs. The cough reflex in these animals was subsequently assessed. NaV 1.7 shRNA was
Harvey E Ramirez et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(4), 426-432 (2015-08-01)
A model system capable of providing clinically relevant analgesic doses with minimal trauma has been elusive in laboratory animal medicine. Our laboratory has developed an orofacial operant pain system that effectively discriminates between non-noxious and noxious thermal stimuli in rats
Lipa Shah et al.
Pharmaceutical research, 31(10), 2724-2734 (2014-05-06)
The main objective of this study was to develop and evaluate therapeutic efficacy and safety following systemic delivery of a peptide analgesic into the CNS using an oil-in-water nanoemulsion system. We have formulated a safe and effective, omega-3 rich polyunsaturated
Hun Sik Kim et al.
Carcinogenesis, 35(7), 1652-1660 (2014-04-20)
The assessment of the biological activity of capsaicin, the compound responsible for the spicy flavor of chili pepper, produced controversial results, showing either carcinogenicity or cancer prevention. The innate immune system plays a pivotal role in cancer pathology and prevention;
Christopher M Peters et al.
Anesthesiology, 120(4), 976-986 (2013-12-04)
Long-lasting, sensory-specific peripheral nerve blockade would advance perioperative analgesia. Perineural injection of a combination of transient receptor potential vanilloid 1 channel agonists and lidocaine or its hydrophilic derivative, QX-314, produces prolonged sensory or nociceptor-selective nerve block in rodents. In this
Hathaichanok Impheng et al.
PloS one, 9(9), e107842-e107842 (2014-09-26)
The inhibition of the mammalian de novo synthesis of long-chain saturated fatty acids (LCFAs) by blocking the fatty acid synthase (FASN) enzyme activity in tumor cells that overexpress FASN can promote apoptosis, without apparent cytotoxic to non-tumor cells. The present
S S Essawy et al.
European review for medical and pharmacological sciences, 17(14), 1857-1863 (2013-07-24)
Inhibition of xanthine oxidase by allopurinol increases hypoxanthine and xanthine, which are converted to purines, including the inhibitory neuromodulator adenosine. We aimed to investigate the antinociceptive effects of allopurinol in thermal and chemical pain models in mice and to evaluate
D C Lagatta et al.
British journal of pharmacology, 172(22), 5377-5389 (2015-09-12)
The ventral portion of the medial prefrontal cortex (vMPFC) comprises the infralimbic (IL), prelimbic (PL) and dorsopenducular (DP) cortices. The IL and PL regions facilitate the baroreceptor reflex arc. This facilitatory effect on the baroreflex is thought to be mediated
Chul-Kyu Park
Mediators of inflammation, 2015, 275126-275126 (2015-12-01)
In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been recognized that maresin 1
Joan Dow et al.
Cardiovascular drugs and therapy, 28(4), 295-301 (2014-05-20)
Topical capsaicin application was shown to reduce infarct size in experimental animal models. We hypothesized that cardioprotective properties of topical capsaicin application could be related to its hypothermic effect. In the first arm of the study, anesthetized rats received capsaicin
Fu-Xiang Yu et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 92(5), 406-412 (2014-10-08)
Hepatic stellate cells (HSCs) play an important role in the process of liver fibrosis. In this study, we investigated the inhibitory effects of capsaicin on HSCs and liver fibrosis. Cultured HSCs were incubated with various concentrations of capsaicin. Cell proliferation
Nico A Jansen et al.
Journal of neurophysiology, 113(1), 58-70 (2014-10-10)
We tested the possibility that the trigeminoparabrachial tract (VcPbT), a projection thought to be importantly involved in nociception, might also contribute to sensation of itch. In anesthetized rats, 47 antidromically identified VcPbT neurons with receptive fields involving the cheek were
V Libri et al.
British journal of anaesthesia, 112(2), 337-347 (2013-09-26)
Treprostinil sodium improves haemodynamics and symptoms in pulmonary arterial hypertension (PAH) patients, but its subcutaneous (s.c.) administration can produce severe local site pain, and lead to discontinuation of vital treatment. Treprostinil is a prostacyclin analogue which stimulates prostacyclin receptors in
Yves Boucher et al.
Neuroscience letters, 543, 37-41 (2013-04-09)
Many patients suffer from trigeminal neuralgia and other types of orofacial pain that are poorly treated, necessitating preclininal animal models for development of mechanisms-based therapies. The present study assessed capsaicin avoidance and other nocifensive behavioral responses in three models of
T P Riley et al.
Journal of neuroimmunology, 257(1-2), 36-45 (2013-03-14)
Vagal activation can reduce inflammation and disease activity in various animal models of intestinal inflammation via the cholinergic anti-inflammatory pathway. In the current model of this pathway, activation of descending vagal efferents is dependent on a signal initiated by stimulation
Szczepan Mogilski et al.
Pharmacology, biochemistry, and behavior, 133, 99-110 (2015-04-08)
The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of the mechanisms involved in the pharmacological activity of these compounds. In
Masaki Mizuno et al.
Hypertension (Dallas, Tex. : 1979), 63(2), 324-329 (2013-11-06)
Adulthood hypertension can be prenatally programmed by maternal dietary protein deprivation. We have shown that the sympathetically mediated pressor response to physical stress is exaggerated in prenatally programmed hypertensive (PPH) rats. The mechanisms underlying this abnormal responsiveness remain undetermined. The
S Javed et al.
Diabetes, obesity & metabolism, 17(12), 1115-1125 (2015-07-17)
The rise in the global burden of diabetes is spurring an increase in the prevalence of its complications. Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, with multiple clinical manifestations. The most common is a symmetrical
Yuni Wahyuni et al.
Journal of natural products, 76(4), 783-793 (2013-03-13)
The genus Capsicum (pepper) comprises a large number of wild and cultivated species. The plants are grown all over the world, primarily in tropical and subtropical countries. The fruits are an excellent source of health-related compounds, such as ascorbic acid
Cheng Zhou et al.
Anesthesiology, 121(2), 280-289 (2014-03-29)
QX-314 produces nociceptive blockade, facilitated by permeation through transient receptor potential vanilloid-1 (TRPV1) channels. TRPV1 channel can be activated by noxious heat and sensitized by volatile anesthetics. The authors hypothesized that emulsified isoflurane (EI) could enhance thermal TRPV1 channel activation-mediated
Jieun Kim et al.
Nature neuroscience, 17(1), 65-72 (2013-11-12)
Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into
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