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Mark E Koina et al.
Investigative ophthalmology & visual science, 56(2), 1310-1327 (2015-01-15)
Lymphatics subserve many important functions in the human body including maintenance of fluid homeostasis, immune surveillance, and tumor metastasis. Our aim was to provide structural and phenotypic evidence of lymphatic-like structures in the human choroid, including details of its development.
Camila Oliveira Goulart et al.
PloS one, 9(10), e110090-e110090 (2014-10-22)
Despite the regenerative potential of the peripheral nervous system, severe nerve lesions lead to loss of target-organ innervation, making complete functional recovery a challenge. Few studies have given attention to combining different approaches in order to accelerate the regenerative process.
Jingjing Li et al.
PloS one, 10(3), e0120440-e0120440 (2015-03-12)
Astaxanthin, a potent antioxidant, exhibits a wide range of biological activities, including antioxidant, atherosclerosis and antitumor activities. However, its effect on concanavalin A (ConA)-induced autoimmune hepatitis remains unclear. The aim of this study was to investigate the protective effects of
Ling-Chao Meng et al.
Chinese medical journal, 128(21), 2902-2905 (2015-11-03)
Mutations of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis, which occurs worldwide. To date, more and more mutations in the TTR gene have been reported. Some variations in the clinical presentation are often observed in
X Zhao et al.
International journal of molecular medicine, 35(3), 684-692 (2015-01-13)
Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein
Shawn Mikula et al.
Nature methods, 9(12), 1198-1201 (2012-10-23)
The development of methods for imaging large contiguous volumes with the electron microscope could allow the complete mapping of a whole mouse brain at the single-axon level. We developed a method based on prolonged immersion that enables staining and embedding
Tamara Muñoz-Caro et al.
Parasitology research, 113(11), 4189-4197 (2014-09-07)
Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia
Urosh Vilimanovich et al.
European journal of pharmacology, 765, 415-428 (2015-09-12)
Statins exhibit anti-leukemic properties due to suppression of the mevalonate pathway by the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, and subsequent depletion of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate. We investigated the role of autophagy, a controlled intracellular self-digestion, in the anti-leukemic
Xiuqing Li et al.
Environmental technology, 36(5-8), 920-928 (2014-09-23)
Microcystis blooms could cause severe problems for drinking water supplies with their associated microcystins (MCs). As the majority of MCs are retained inside the cells, the effective removal of the intact Microcystis cells to avoid the release of additional MCs
Robert Silasi-Mansat et al.
Journal of cellular and molecular medicine, 19(11), 2549-2563 (2015-09-05)
Acute respiratory distress syndrome (ARDS) induced by severe sepsis can trigger persistent inflammation and fibrosis. We have shown that experimental sepsis in baboons recapitulates ARDS progression in humans, including chronic inflammation and long-lasting fibrosis in the lung. Complement activation products
Uttio Roy Chowdhury et al.
PloS one, 10(11), e0141783-e0141783 (2015-11-05)
Elevated intraocular pressure (IOP) is the most prevalent and only treatable risk factor for glaucoma, a leading cause of irreversible blindness worldwide. Unfortunately, all current therapeutics used to treat elevated IOP and glaucoma have significant and sometimes irreversible side effects
Matthia A Karreman et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(3), 236-247 (2012-12-25)
One of the major challenges for correlative microscopy is the preparation of the sample; the protocols for transmission electron microscopy (TEM) and fluorescence microscopy (FM) often prove to be incompatible. Here, we introduce 2+Staining: an improved contrasting procedure for Tokuyasu
Lucyna Mrówczyńska et al.
Biochemical and biophysical research communications, 422(4), 776-779 (2012-05-29)
The membrane-curvature dependent lateral distribution of outer leaflet ganglioside GM1 (GM1) and the influence of GM1 cross-linking induced by fluorophore-tagged cholera toxin subunit B (CTB) plus anti-CTB was analysed in cell membranes by fluorescence microscopy. Data are presented indicating that
Tao Zuo et al.
Food & function, 6(3), 981-986 (2015-02-12)
Gastrointestinal mucositis induced by chemotherapy is associated with alterations of intestinal barrier function due to the potential damage induced by anti-cancer drugs on the epithelial cells. Goblet cells, an important epithelial lining in the intestine, contribute to innate immunity by
Tatsuya Suzuki et al.
Scientific reports, 5, 7668-7668 (2015-01-09)
The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized.
Chieh-Cheng Huang et al.
Biomaterials, 74, 53-63 (2015-10-09)
A recurring obstacle in cell-base strategies for treating ischemic diseases is the significant loss of viable cells that is caused by the elevated levels of regional reactive oxygen species (ROS), which ultimately limits therapeutic capacity. In this study, aggregates of
Lamjed Mansour et al.
Folia parasitologica, 62 (2015-05-12)
During a survey the occurrence of Kudoa quraishii Mansour, Harrath, Abd-Elkader, Alwasel, Abdel-Baki et Al Omar, 2014, recently identified in the muscles of the Indian mackerel, Rastrelliger kanagurta (Cuvier), a species of Kudoa Meglitsch, 1947 infecting oocytes of mature females
Ruma Kumari et al.
PloS one, 10(11), e0142199-e0142199 (2015-11-07)
To determine the sex and age-related effects of C1qa ablation on retinal ganglion cell (RGC) and optic nerve (ON) axonal loss in a mouse model of glaucomatous neurodegeneration. Congenic C1qa mice were generated in the DBA/2NNia background. Female and male
Ognian C Ikonomov et al.
Biochimica et biophysica acta, 1853(5), 1240-1250 (2015-01-27)
The evolutionarily conserved PIKfyve, which synthesizes PtdIns5P from PtdIns, and PtdIns(3,5)P2 from PtdIns3P, requires PtdIns3P as both an enzyme substrate and a membrane recruitment signal. Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of
Recep Demir et al.
The International journal of neuroscience, 124(12), 935-943 (2014-03-13)
The present study aimed to demonstrate protective effects of alpha lipoic acid on experimental sciatic nerve crush injury model assessed with functional and electronmicroscopy analyses. In this study, groups were; Group 1; sham operated, Group 2; applied only sciatic nerve
Masashi Fujihara et al.
Investigative ophthalmology & visual science, 55(11), 7285-7295 (2014-10-16)
Mice typically produce apolipoprotein B (apoB)-48 and not apoB100. Apolipoprotein B100 accumulates in Bruch's membrane prior to basal deposit and drusen formation during the onset of AMD, raising the possibility that they are a trigger for these Bruch's membrane alterations.
Jie Yuan et al.
Stem cell research & therapy, 6, 217-217 (2015-11-07)
Adult stem cell-derived hepatocytes transplantation holds considerable promise for future clinical individualized therapy of liver failure or dysfunction. However, the low engraftment of the available hepatocytes in the liver disease microenvironment has been a major obstacle. Acellular human amniotic membrane
Kaja Nordengen et al.
Brain structure & function, 220(2), 899-917 (2014-01-01)
The role of N-acetylaspartate in the brain is unclear. Here we used specific antibodies against N-acetylaspartate and immunocytochemistry of carbodiimide-fixed adult rodent brain to show that, besides staining of neuronal cell bodies in the grey matter, N-acetylaspartate labelling was present
Aurelie Vivares et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)
1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in
Jamie Hinks et al.
Applied and environmental microbiology, 81(6), 1949-1958 (2015-01-13)
The modification of microbial membranes to achieve biotechnological strain improvement with exogenous small molecules, such as oligopolyphenylenevinylene-conjugated oligoelectrolyte (OPV-COE) membrane insertion molecules (MIMs), is an emerging biotechnological field. Little is known about the interactions of OPV-COEs with their target, the
Silvana Penco et al.
Journal of molecular neuroscience : MN, 46(2), 427-430 (2011-08-03)
A number of features of the pathology occurring in spontaneously hypertensive stroke prone rats (SHRSPs), such as MRI brain signal abnormalities, the presence of high protein content in cerebrospinal fluid and vessel wall thickening, seem to indicate that this strain
Michelle Schollert et al.
Plant, cell & environment, 38(10), 2048-2060 (2015-03-05)
Biogenic volatile organic compound (BVOC) emissions are expected to change substantially because of the rapid advancement of climate change in the Arctic. BVOC emission changes can feed back both positively and negatively on climate warming. We investigated the effects of
Andrew P Shinn et al.
Journal of invertebrate pathology, 125, 81-86 (2014-12-17)
An outbreak of the sessile peritrich Zoothamnium duplicatum in a pilot, commercial-scale Limulus polyphemus hatchery resulted in the loss of ∼96% (40,000) second/third instar larvae over a 61day period. peritrich growth was heavy, leading to mechanical obstruction of the gills
Vineet Choudhary et al.
The Journal of cell biology, 211(2), 261-271 (2015-10-28)
Lipid droplets (LDs) are found in all cells and play critical roles in lipid metabolism. De novo LD biogenesis occurs in the endoplasmic reticulum (ER) but is not well understood. We imaged early stages of LD biogenesis using electron microscopy
James P Bernot et al.
The Journal of parasitology, 101(2), 167-181 (2014-12-17)
This paper aims to resolve the dual composition of the triakid shark-hosted tetraphyllidean genus Calliobothrium--an issue that has been recognized for over a decade. As it stands, this genus includes a number of large species with laciniate proglottids, most of
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