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Carey A Hobbs et al.
The Journal of physiology, 591(18), 4377-4387 (2013-07-24)
Airway epithelia absorb Na+ through the epithelial Na+ channel (ENaC) and secrete Cl- through the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. This balance maintains sufficient airway surface liquid hydration to permit efficient mucus clearance, which is needed to
Rosalinda Madonna et al.
Vascular pharmacology, 59(5-6), 127-130 (2013-10-22)
Sodium-hydrogen exchangers (NHE) are among the main regulators of cell volume and intracellular concentration of hydrogen and sodium ions. By indirectly affecting sodium/calcium exchange across the plasma membrane, NHE can also influence the intracellular concentration of calcium. Excess activation of
Jia-Wei Wang et al.
The Journal of surgical research, 191(2), 448-454 (2014-05-20)
A wealth of evidence from animal experiments has indicated that hypertonic saline (HS) maybe a better choice for fluid resuscitation in traumatic hypovolemic shock in comparison with conventional isotonic saline. However, the results of several clinical trials raised controversies on
Liangjie Yin et al.
Health physics, 106(6), 734-744 (2014-04-30)
Electrolyte and nutrient absorption occur in villous epithelial cells. Radiation often results in reduced electrolyte and nutrient absorption, which leads to gastrointestinal toxicity. Therefore, the authors studied: (1) radiation-induced changes in glucose and amino acid absorption across ileal tissues and
Pierre Martin et al.
Chimia, 67(4), 204-206 (2013-08-24)
The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2.
Young Jo Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20912-20917 (2013-12-11)
Biodegradable electronics represents an attractive and emerging paradigm in medical devices by harnessing simultaneous advantages afforded by electronically active systems and obviating issues with chronic implants. Integrating practical energy sources that are compatible with the envisioned operation of transient devices
Yasser Elshahawy et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(3), 507-513 (2013-05-04)
To evaluate the individualization of dialysate sodium (Na + ) concentration in hemodialysis (HD), we studied 40 stable chronic HD patients in a single-blind crossover design. They underwent 36 consecutive HD sessions with the dialysate Na + concentration set at
Srinivas Rengarajan et al.
American journal of physiology. Renal physiology, 306(9), F1059-F1068 (2014-03-07)
Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated with reduced phosphorylation (p) of the distal tubule Na(+)-Cl(-) cotransporter (NCC). Decreased NCC-p inhibits NCC-mediated Na(+) reabsorption and shifts Na(+) downstream for reabsorption by epithelial Na(+) channels (ENaC), which
Peng Zhai et al.
Biomedical materials (Bristol, England), 10(4), 045016-045016 (2015-08-05)
The adult mammalian central nervous system has limited ability to regenerate after injury. This is due, in part, to the presence of myelin-associated axon growth inhibitory proteins such as Nogo-A that bind and activate the Nogo receptor, leading to profound
Tahir Rafique et al.
Water environment research : a research publication of the Water Environment Federation, 85(7), 579-586 (2013-08-16)
The role of seawater dilution, along with other water-quality components, has been studied to determine the causes of spatial distribution of high fluoride concentrations in the groundwater of the Diplo sub-district, Thar Desert, Pakistan. Fluoride ion concentration ranges of up
Paul A Welling
Current opinion in nephrology and hypertension, 23(1), 1-8 (2013-11-21)
Recent efforts to explore the genetic underpinnings of hypertension revealed rare mutations in kidney salt transport genes contribute to blood pressure (BP) variation and hypertension susceptibility in the general population. The current review focuses on these latest findings, highlighting a
Todd Scheuer
Handbook of experimental pharmacology, 221, 269-291 (2014-04-17)
Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts. Key elements of
Patrícia Severino et al.
Colloids and surfaces. B, Biointerfaces, 129, 191-197 (2015-04-13)
Polymyxins are a group of antibiotics with a common structure of a cyclic peptide with a long hydrophobic tail. Polymyxin B sulphate (PLX) has cationic charge, which is an obstacle for the efficient loading into Solid Lipid Nanoparticles (SLN). In
Wei-Zhong Ying et al.
American journal of physiology. Renal physiology, 307(1), F58-F63 (2014-05-03)
The amount of Na(+) and K(+) in the diet promotes significant changes in endothelial cell function. In the present study, a series of in vitro and in vivo experiments determined the role of Na(+) and K(+) in the regulation of
S S Pati et al.
Journal of nanoscience and nanotechnology, 14(6), 4114-4123 (2014-04-18)
We investigate the effect of sodium trapping on thermal stability of magnetite (Fe3O4) nanoparticles. The pure magnetite nanoparticles incubated in sodium hydroxide solutions and subsequently washed with water to remove the excess sodium. The amount of sodium in magnetite is
Liangjie Yin et al.
American journal of physiology. Cell physiology, 306(7), C687-C696 (2014-01-31)
The sodium-coupled glucose transporter-1 (SGLT1)-based oral rehydration solution (ORS) used in the management of acute diarrhea does not substantially reduce stool output, despite the fact that glucose stimulates the absorption of sodium and water. To explain this phenomenon, we investigated
August Wrotek et al.
Advances in experimental medicine and biology, 835, 31-36 (2014-09-26)
Copeptin has been associated with the severity of pneumonia and its complications. This study was designed to assess the usefulness of copeptin measurement in children with community-acquired pneumonia (CAP) and copeptin's relation with disease severity and sodium equilibrium. The study
Supriya S Jalimarada et al.
Investigative ophthalmology & visual science, 54(6), 4330-4340 (2013-06-08)
Mutations in SLC4A11, a member of the SLC4 superfamily of bicarbonate transporters, give rise to corneal endothelial cell dystrophies. SLC4A11 is a putative Na⁺ borate and Na⁺:OH⁻ transporter. Therefore we ask whether SLC4A11 in corneal endothelium transports borate (B[OH]₄⁻), bicarbonate
Michael Biet et al.
Circulation. Arrhythmia and electrophysiology, 8(4), 912-920 (2015-06-13)
Arrhythmias associated with QT prolongation on the ECG often lead to sudden unexpected death in epilepsy. The mechanism causing a prolongation of the QT interval during epilepsy remains unknown. Based on observations showing an upregulation of neuronal sodium channels in
Sebastien Racinais et al.
International journal of sports physiology and performance, 9(4), 598-603 (2013-10-04)
To examine the physiological and performance responses to a heat-acclimatization camp in highly trained professional team-sport athletes. Eighteen male Australian Rules Football players trained for 2 wk in hot ambient conditions (31-33°C, humidity 34-50%). Players performed a laboratory-based heat-response test
Amiraj Banga et al.
American journal of physiology. Lung cellular and molecular physiology, 306(10), L937-L946 (2014-04-08)
Calu-3 is a well-differentiated human bronchial cell line with the characteristics of the serous cells of airway submucosal glands. The submucosal glands play a major role in mucociliary clearance because they secrete electrolytes that facilitate airway hydration. Given the significance
Umut Yucel et al.
Journal of agricultural and food chemistry, 63(34), 7494-7498 (2015-08-11)
There is a broad need to reformulate lower sodium food products without affecting their original taste. The present study focuses on characterizing the role of protein-salt interactions on the salt release in low-moisture systems and saltiness perception during hydration. Sodium
Robert D Gray et al.
Journal of molecular biology, 426(8), 1629-1650 (2014-02-04)
Sequence analogs of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into monomeric quadruplex structures in the presence of a suitable cation. To investigate the pathway for unimolecular quadruplex formation, we monitored the kinetics of K(+)-induced folding of Tel22 by
Jeffrey D Calhoun et al.
Handbook of experimental pharmacology, 221, 51-89 (2014-04-17)
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α subunits in brain. The other family members, β1B, β3, and β4, were identified by homology and shown to modulate sodium current in heterologous
Hana R Pohl et al.
Metal ions in life sciences, 13, 29-47 (2014-01-29)
Sodium and potassium are essential for human health. They are important ions in the body and are associated with many physiologic and pathophysiologic processes. The chapter summarizes the basic physiologic actions of sodium and potassium on membranes of the neurologic
Matthew F Rouhier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R850-R861 (2014-07-25)
The effect of two small molecules VU342 and VU573 on renal functions in the yellow fever mosquito Aedes aegypti was investigated in vitro and in vivo. In isolated Malpighian tubules, VU342 (10 μM) had no effect on the transepithelial secretion
Julijana Vuchkova et al.
American journal of physiology. Renal physiology, 307(5), F525-F532 (2014-07-06)
Albuminuria in nephrotic states is thought to arise from the formation of large pores in the glomerular capillary wall as large hydrodynamic probes, like Ficoll, have increased fractional clearance. In the present study, we tested for large pore formation in
The reply.
Gregor Lindner et al.
The American journal of medicine, 126(6), e15-e15 (2013-05-21)
Lenar Yessayan et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 64(2), 305-310 (2014-05-06)
Patients with hypervolemic hyponatremia and kidney failure pose a special therapeutic challenge. Hemodialysis to correct volume overload, azotemia, and abnormal electrolyte levels will result in rapid correction of serum sodium concentration and place the patient at risk for osmotic demyelination
[The cutting-edge of medicine; novel therapeutic agents for the treatment of diabetes sodium-glucose co-transporter (SGLT) 2 inhibitors].
Toshiro Sugimoto et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(6), 1474-1483 (2013-08-21)
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