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Jong-Suep Baek et al.
Archives of pharmacal research, 38(5), 761-768 (2014-05-14)
Ginsenoside saponins are phytochemically extracted from red ginseng and have been regarded as the principal components manifesting the pharmacologic activities. Saponins are very soluble in water but poorly absorbed when orally administrated. Moreover, they have some disadvantages including the decomposition
P G J ter Horst et al.
Journal of clinical pharmacy and therapeutics, 39(5), 541-544 (2014-07-06)
Depression during pregnancy is common and includes risks for mother and child. Pharmacokinetics of venlafaxine may be changed during pregnancy. This study aimed to describe changes in metabolic ratios and concentrations of venlafaxine and its main metabolite O-desmethylvenlafaxine during and
Jiang Ma et al.
Journal of ethnopharmacology, 162, 61-68 (2015-01-06)
Polygoni Multiflori Radix (PMR) has been traditionally used as a tonic and an anti-aging remedy for centuries; however, hepatic lesions linked to PMR have been frequently reported. This work attempted to investigate the hepatotoxic potential of PMR extract and the
Paresh A Parmar et al.
Biomaterials, 54, 213-225 (2015-04-25)
Regenerative medicine strategies for restoring articular cartilage face significant challenges to recreate the complex and dynamic biochemical and biomechanical functions of native tissues. As an approach to recapitulate the complexity of the extracellular matrix, collagen-mimetic proteins offer a modular template
Francesco Menichini et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 677-685 (2013-10-10)
Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using
Rachumallu Ramakrishna et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 185-197 (2015-04-23)
Azilsartan medoxomil (AZM), an ester prodrug of azilsartan (AZ), and chlorthalidone (CLT) have recently been approved as a combination therapy for the management of hypertension. This is the first report which described a selective and sensitive method for the simultaneous
Ahmad Aqel et al.
Journal of chromatographic science, 52(3), 201-210 (2013-02-21)
This paper describes the comprehensive fabrication of monolithic materials for use as stationary phases in capillary liquid chromatography. Several columns were synthesized in the confines of 320 µm i.d. fused-silica capillaries by single-step in situ copolymerization of benzyl methacrylate and
Sandra K Willsie et al.
Clinical therapeutics, 37(1), 145-155 (2014-12-30)
Sufentanil is a μ-opioid agonist with a high therapeutic index in preclinical studies and no active metabolites, and it is highly lipophilic, thereby enabling a transmucosal route of administration. Rapid distribution from the plasma after IV sufentanil administration results in
Farag Ibraheem et al.
Molecules (Basel, Switzerland), 20(2), 2388-2404 (2015-02-04)
Sorghum responds to the ingress of the fungal pathogen Colletotrichum sublineolum through the biosynthesis of 3-deoxyanthocyanidin phytoalexins at the site of primary infection. Biosynthesis of 3-deoxyanthocyanidins in sorghum requires a MYB transcription factor encoded by yellow seed1 (y1), an orthologue
Hüma Yılmaz et al.
Journal of separation science, 38(17), 3090-3095 (2015-07-04)
A simple, sensitive, and selective molecularly imprinted solid-phase extraction and spectrophotometric method has been developed for the clean-up and preconcentration of indapamide from human urine. Molecularly imprinted polymers were prepared by a non-covalent imprinting approach using indapamide as a template
Priscilla Siqueira Melo et al.
Food chemistry, 181, 160-169 (2015-03-22)
Nearly 20 million tons of winery by-products, with many biological activities, are discarded each year in the world. The extraction of bioactive compounds from Chenin Blanc, Petit Verdot, and Syrah grape by-products, produced in the semi-arid region in Brazil, was
Bandita Panda et al.
Journal of proteomics, 127(Pt A), 152-160 (2015-05-28)
Three strains of photoautotrophic, heterocystous, nitrogen-fixing cyanobacterium Anabaena, native to Indian paddy fields, were examined for their tolerance and proteomic response to the frequently used weedicide paraquat (methyl viologen). Anabaena 7120 (LD50 dose: 2μM for 6h) and Anabaena L-31 (LD50
Mir Ali Farajzadeh et al.
Analytica chimica acta, 885, 122-131 (2015-08-02)
In this paper, a new version of salting-out homogenous liquid-liquid extraction based on counter current mode combined with dispersive liquid-liquid microextraction has been developed for the extraction and preconcentration of some pesticides from aqueous samples and their determination by gas
Aurelia Kuster et al.
The Journal of biological chemistry, 290(47), 28056-28069 (2015-09-12)
SNAREs constitute the core machinery of intracellular membrane fusion, but vesicular SNAREs localize to specific compartments via largely unknown mechanisms. Here, we identified an interaction between VAMP7 and SNAP-47 using a proteomics approach. We found that SNAP-47 mainly localized to
Sai-Zhen Chen et al.
International journal of clinical pharmacology and therapeutics, 52(9), 732-738 (2014-07-06)
Co-administration of anti-hypertension and anti-diabetic drugs is common in clinical settings. In this study, we characterized the drug-drug interactions of losartan (LOS) and glimepiride (GLP) using recombinant cytochrome P450 (CYP) 2C9 enzymes (CYP2C9*1, CYP2C9*3, CYP2C9*13, and CYP2C9*16). Metabolism of losartan
Diane E Cole et al.
Cancer chemotherapy and pharmacology, 75(5), 923-928 (2015-03-06)
Central nervous system tumors are histologically and biologically heterogeneous. Standard treatment for malignant tumors includes surgery, radiation and chemotherapy, yet surgical resection is not always an option and chemotherapeutic agents have limited benefit. Recent investigations have focused on molecularly targeted
Virginia Carvalhais et al.
Applied microbiology and biotechnology, 99(6), 2751-2762 (2015-02-13)
Staphylococcus epidermidis is an important nosocomial bacterium among carriers of indwelling medical devices, since it has a strong ability to form biofilms. The presence of dormant bacteria within a biofilm is one of the factors that contribute to biofilm antibiotic
Jae Wook Lee et al.
ChemMedChem, 10(9), 1489-1497 (2015-07-16)
Small-molecule probes have been playing prominent roles in furthering our understanding of the molecular underpinnings of the circadian clock. We previously discovered a carbazole derivative, KL001 (N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide), as a stabilizer of the clock protein cryptochrome (CRY). Herein we describe an
Rebecca L Dalton et al.
Environmental pollution (Barking, Essex : 1987), 189, 134-142 (2014-03-26)
Polar organic chemical integrative samplers (POCIS) were used to estimate atrazine contamination at 24 stream/river sites located across a watershed with land use ranging from 6.7 to 97.4% annual crops and surface water nitrate concentrations ranging from 3 to 5404 μg/L.
Vinita Chauhan et al.
Protein and peptide letters, 22(9), 844-852 (2015-08-19)
Shiga toxin family comprises toxins belonging to two major groups, Stx1 and Stx2, produced by the bacteria Shigella dysenteriae and some strains of Escherichia coli. Shiga toxins are the leading cause of diarrhea associated with life threatening hemolytic uremic syndrome
Lan-Jie Li et al.
Journal of separation science, 38(17), 3055-3062 (2015-06-18)
A method of ionic liquid salt aqueous two-phase extraction coupled with high-performance liquid chromatography has been developed for the analysis of seven rare ginsenosides including Rg6 , F4 , 20(S)-Rg3 , 20(R)-Rg3 , Rk3 , Rk1 , and Rg5 in
Valentina Trotta et al.
Drug development and industrial pharmacy, 40(9), 1233-1239 (2013-07-11)
Essential requirements for the efficacy of sunscreen agents are optimal UV absorption, high photostability and resistance against water removal. Aim of this study was to investigate the effect of encapsulation in lipid microparticles (LMs) on the overall performance of the
Xi-Wen Tong et al.
Scientific reports, 5, 12542-12542 (2015-07-28)
The migratory locust displays a reversible, density-dependent transition between the two phases of gregaria and solitaria. This phenomenon is a typical kind of behavior plasticity. Here, we report that COP9 signalosome complex subunit 7A (CSN7A) is involved in the regulation
Xanel Vecino et al.
Journal of agricultural and food chemistry, 63(32), 7143-7150 (2015-07-25)
A decontamination technique based on the utilization of a lipopeptide biosurfactant extracted from corn steep liquor has been developed to eliminate polycyclic aromatic hydrocarbons (PAHs) from sewage sludge. High concentrations of PAHs were used during experiments observing that 408.3 mg/kg
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used
Richard H Lindberg et al.
Water research, 58, 221-229 (2014-04-29)
The concentrations and behaviour of 105 different active pharmaceutical ingredients (APIs) in the aqueous phase of sewage water within a municipal sewer collection system have been investigated. Sewage water samples were gathered from seven pump stations (one of which was
Islam Amine Larabi et al.
Journal of analytical toxicology, 39(9), 720-725 (2015-09-06)
A liquid chromatography-MS-MS turbulent flow on-line extraction method was developed for the determination of trimebutine (TMB) and its main active metabolite N-mono-desmethyltrimebutine (nortrimebutine or nor-TMB) in human plasma. After protein precipitation and internal standard (IS, haloperidol-d4) addition, 50 µL of
Yong Fan et al.
Journal of pharmaceutical and biomedical analysis, 95, 213-219 (2014-04-02)
Sample extraction is the first challenge in analysis of herbal medicines (HMs). Numerous methods have been developed to improve extraction efficiency, use less solvent and short time. In this work, a tissue-smashing based ultra-rapid extraction (TSURE) method has been proposed
Hiroaki Tamaki et al.
PloS one, 10(6), e0131213-e0131213 (2015-06-23)
Sink/source relationships, regulating the mobilization of stored carbohydrates from the vegetative tissues to the grains, are of key importance for grain filling and grain yield. We used different inhibitors of plant hormone action to assess their effects on grain yield
Liming Wu et al.
Food chemistry, 173, 1111-1118 (2014-12-04)
Nucleotides, nucleosides and nucleobases play a greater role in the physiological activity of organisms which are highly present in royal jelly (RJ). The objective of the present study is to develop a HPLC method to simultaneous determine nucleotides, nucleosides and
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