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Shugeng Cao et al.
Journal of natural products, 69(4), 707-709 (2006-04-29)
Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2...
Rameshwar R Rao et al.
Tissue engineering. Part A, 21(3-4), 530-540 (2014-09-18)
Minimally invasive, injectable bone tissue engineering therapies offer the potential to facilitate orthopedic repair procedures, including in indications where enhanced bone regeneration is needed for complete healing. In this study, we developed a dual-phase tissue construct consisting of osteogenic (Osteo)...
Takeshi Tomita et al.
PloS one, 10(3), e0118835-e0118835 (2015-03-05)
Serum amyloid A3 (SAA3) possesses characteristics distinct from the other serum amyloid A isoforms, SAA1, SAA2, and SAA4. High density lipoprotein contains the latter three isoforms, but not SAA3. The expression of mouse SAA3 (mSAA3) is known to be up-regulated...
Marie Nollet et al.
Autophagy, 10(11), 1965-1977 (2014-12-09)
Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption, and osteocytes, the multifunctional mechanosensing cells embedded in the bone matrix, are the main actors....
Rui Wang et al.
Journal of molecular endocrinology, 53(3), 405-415 (2014-10-18)
WNT/β-catenin signalling is involved in regulating adipogenesis, and its dysregulation occurs in obesity. Secreted frizzled-related protein 5 (SFRP5) is a WNT protein inhibitor; however, its role in adipogenesis and obesity is controversial. In this study, we observed that SFRP5 mRNA...
Sachin Kumar et al.
ACS applied materials & interfaces, 7(5), 3237-3252 (2015-01-15)
Toward designing the next generation of resorbable biomaterials for orthopedic applications, we studied poly(ε-caprolactone) (PCL) composites containing graphene. The role, if any, of the functionalization of graphene on mechanical properties, stem cell response, and biofilm formation was systematically evaluated. PCL...
Delfo D'Alessandro et al.
Biomedical materials (Bristol, England), 9(4), 045007-045007 (2014-07-17)
In this study, we performed a complete histologic analysis of constructs based on large diameter ( >100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding....
Chul Han Kim et al.
Journal of Korean medical science, 26(6), 726-733 (2011-06-10)
We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of Sprague-Dawley rats. One site was covered with a 3D collagen...
Jia Huang et al.
Molecular medicine reports, 11(3), 1777-1783 (2014-11-08)
The aim of the present study was to investigate the morphological characteristics and pluripotent differentiation potential of human bone marrow mesenchymal stem cells (hBMMSCs) in vitro and in vivo. Bone marrow cells were isolated from a rib fragment of an...
Hossein Nejadnik et al.
Stem cell reviews, 11(2), 242-253 (2015-01-13)
Human induced pluripotent stem cells (hiPSCs) have demonstrated great potential for hyaline cartilage regeneration. However, current approaches for chondrogenic differentiation of hiPSCs are complicated and inefficient primarily due to intermediate embryoid body formation, which is required to generate endodermal, ectodermal...
J-H La et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1730-1742 (2014-10-14)
A low-level inflammation has been hypothesized to mediate visceral hypersensitivity in functional bowel disorders that persist after or even in the absence of gut inflammation. We aimed to test the efficacy of a steroidal anti-inflammatory treatment, and identify local inflammatory...
Louise Grahnemo et al.
The Journal of endocrinology, 224(1), 97-108 (2014-11-02)
Treatment with anti-inflammatory glucocorticoids is associated with osteoporosis. Many of the treated patients are postmenopausal women, who even without treatment have an increased risk of osteoporosis. Lymphocytes have been shown to play a role in postmenopausal and arthritis-induced osteoporosis, and...
Manuela Zavatti et al.
Life sciences, 121, 174-183 (2014-12-03)
This study aims to evaluate the bone regeneration in a rat calvarias critical size bone defect treated with a construct consisting of collagen type I and human amniotic fluid stem cells (AFSCs) after oral administration of phytoestrogen ferutinin. In 12...
Reza Roozafzoon et al.
Biochemical and biophysical research communications, 457(2), 154-160 (2014-12-30)
The loss of retinal ganglion cells (RGCs) in majority of retinal degenerative diseases is the first seen pathological event. A lot of studies aim to discover suitable cell sources to replace lost and damaged RGCs. Among them dental pulp stem...
Bingwei V Yang et al.
Bioorganic & medicinal chemistry letters, 19(8), 2139-2143 (2009-03-27)
A series of dihydro-9,10-ethano-anthracene-11-carboxamides as novel glucocorticoid receptor modulators is reported. SAR exploration identified compounds from this series displaying a promising dissociation profile in discriminating between transrepression and transactivation activities. 17a is a partial agonist of GR-mediated transactivation which elicits...
Bahman Naghipour et al.
Middle East journal of anaesthesiology, 22(1), 53-57 (2013-07-10)
Different additives have been used to prolong regional blockade. We designed a prospective, randomized, double-blind, controlled clinical trial to evaluate the effect of dexamethasone added to bupivacaine-fentanyl on the duration of postoperative analgesia via epidural catheterization. Seventy two adult patients...
Daniela Choukair et al.
Pediatric research, 76(3), 245-251 (2014-06-19)
Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinflammatory cytokines interfere with IGF-I signaling. We used the mesenchymal chondrogenic cell line RCJ3.1C5.18...
Kasima Ekthuwapranee et al.
The Journal of steroid biochemistry and molecular biology, 145, 38-48 (2014-10-12)
Glucocorticoids, hormones that are released in response to stress, induce neuronal cell damage. The hippocampus is a primary target of glucocorticoids in the brain, the effects of which include the suppression of cell proliferation and diminished neurogenesis in the dentate...
Satomi Nagao et al.
Neuropeptides, 48(6), 399-406 (2014-12-04)
Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic...
Stefan A Mann et al.
Journal of neuroinflammation, 5, 39-39 (2008-09-24)
Periventricular leukomalacia (PVL) is a frequent complication of preterm delivery. Proinflammatory cytokines, such as interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) released from astrocytes and microglia activated by infection or ischemia have previously been shown to impair survival and...
Alice Toniolo et al.
The Journal of clinical endocrinology and metabolism, 100(1), E50-E58 (2014-10-11)
During their reproductive years, women are generally protected from cardiovascular disease events by their estrogen-replete status. Our starting hypothesis was that lower estrogen levels after menopause are associated with macrophage activation profiles skewed toward proinflammatory phenotypes. Research Design and Setting:...
Perineural vs intravenous administration of dexamethasone: more data are available.
E Albrecht et al.
British journal of anaesthesia, 114(1), 160-160 (2014-12-17)
Perineural dexamethasone and multimodal perineural analgesia: how much is too much?
Brian A Williams et al.
Anesthesia and analgesia, 118(5), 912-914 (2014-05-02)
Ruiping Zhou et al.
PloS one, 9(8), e104392-e104392 (2014-08-08)
Mesenchymal stem cells (MSCs) have exhibited therapeutic effects in multiple animal models so that are promising liver substitute for transplantation treatment of end-stage liver diseases. However, it has been shown that over-manipulation of these cells increased their tumorigenic potential, and...
Nan Yang et al.
The Journal of endocrinology, 223(2), 155-166 (2014-08-28)
Glucocorticoids (Gc) are potent anti-inflammatory agents with wide clinical application. We have previously shown that increased serum concentration significantly attenuates regulation of a simple Gc-responsive reporter. We now find that glucocorticoid receptor (GR) regulation of some endogenous transactivated but not...
J-H Lee et al.
Transplantation proceedings, 46(5), 1633-1637 (2014-06-18)
Liver transplantation is severely limited by donor shortage although it is the only effective treatment for end-stage liver disease. So the best alternative is hepatocyte transplantation. For obtaining human hepatocytes, some stem cells originating from extrahepatic or intraheptic tissues have...
Rei Ogawa et al.
Tissue engineering. Part A, 21(1-2), 257-266 (2014-07-26)
The chondrogenic potential of adipose-derived stem cells (ASCs) has been previously demonstrated, although several reports have indicated that ASCs produce less cartilage-specific matrix than bone marrow-derived mesenchymal stem cells. In this study, we intended to improve chondrogenic phenotypes of ASCs...
Yajun Chen et al.
American journal of physiology. Lung cellular and molecular physiology, 306(8), L797-L807 (2014-02-04)
Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-κB...
Erika Mariana Palmieri et al.
FEBS letters, 588(24), 4807-4814 (2014-12-03)
The role of glutamine synthetase (GS) during adipocyte differentiation is unclear. Here, we assess the impact of GS on the adipocytic response to a proinflammatory challenge at different differentiation stages. GS expression at the late stages of differentiation desensitized mature...
Cameron L Nemeth et al.
Tissue engineering. Part A, 20(21-22), 2817-2829 (2014-04-23)
We have examined the effects of surface nanotopography and hyaluronic acid (HA) on in vitro chondrogenesis of dental pulp stem cells (DPSCs). Ultraviolet-assisted capillary force lithography was employed to fabricate well-defined nanostructured scaffolds of composite PEG-GelMA-HA hydrogels that consist of...
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