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322415

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J W La Claire et al.
Toxicon : official journal of the International Society on Toxinology, 102, 74-80 (2015-06-17)
A fluorometric assay was developed to semi-quantify co-purified polyketide prymnesins-1 and -2 (PPs) from Prymnesium parvum cultures. Evaluations performed throughout the growth cycle of 5 practical salinity unit (PSU) cultures detected relatively 8-10 × more PPs in the culture medium (exotoxins) than...
Rosa Perestrelo et al.
Journal of chromatography. A, 1381, 54-63 (2015-01-27)
An improved, reliable and powerful analytical strategy based on digitally controlled microextraction by packed sorbent (MEPS) combined with ultrahigh pressure liquid chromatography (UHPLC) was validated for the simultaneous identification and quantification of major furanic derivatives, namely 5-hydroxymethyl-2-furaldehyde (5HMF), 5-methyl-2-furaldehyde (5MF)...
Banu Kaskatepe et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 46(3), 855-859 (2015-09-29)
The aim of this study was to increase rhamnolipid production by formulating media using kefir and fish meal for Pseudomonas aeruginosa strains isolated from different environmental resources. The strains, named as H1, SY1, and ST1, capable of rhamnolipid production were...
Longhai Dai et al.
Plant & cell physiology, 56(6), 1172-1182 (2015-03-12)
Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities. Mogrosides are synthesized from 2,3-oxidosqualene...
Satoshi Hara et al.
The American journal of pathology, 185(8), 2118-2131 (2015-06-15)
Intracapillary foam cell infiltration with podocyte alterations is a characteristic pathology of focal segmental glomerulosclerosis (FSGS). We investigated the possible role of podocyte injury in glomerular macrophage and foam cell infiltration in a podocyte-selective injury model (NEP25 mice) and hypercholesterolemic...
Mahmoud Salah Khalil
Histology and histopathology, 30(7), 855-864 (2015-02-06)
There are many available drugs for treating gastric ulcer, but they have various side effects. Ginger is a folk, herbal medicine, which is used for treatment of various diseases including gastric ulcer. This study investigates the possible mechanism of the...
Jae H Park et al.
Journal of medicinal chemistry, 57(15), 6623-6631 (2014-07-16)
The aqueous solution structure of protoxin II (ProTx II) indicated that the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region, similar to previously described NaSpTx III tarantula toxins. In the present study...
A Gottås et al.
Journal of pharmacological and toxicological methods, 74, 75-79 (2015-07-01)
An increase in striatal dopamine is considered essential for the rewarding and reinforcing effects of drugs of abuse. We have developed and validated an ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for the analysis of dopamine in...
Zhenchang Liang et al.
PloS one, 9(8), e105146-e105146 (2014-08-19)
Grapes are rich in phytochemicals with many proven health benefits. Phenolic profiles, antioxidant and antiproliferative activities of twenty-four selected Vitis vinifera grape cultivars were investigated in this study. Large ranges of variation were found in these cultivars for the contents...
Lakshmi Gopinathan et al.
Cancer research, 74(14), 3870-3879 (2014-05-08)
Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed...
Weifeng Liu et al.
Molecular biotechnology, 57(10), 914-922 (2015-07-24)
Many immune ligands and receptors are potential drug targets, which delicately manipulate a wide range of immune responses. We describe here the successful application of an efficient method to dramatically improve the heterologous expression levels in Drosophila Schneider 2 cells...
Carla M Teglia et al.
Analytical and bioanalytical chemistry, 406(30), 7989-7998 (2014-11-06)
This paper reports the development of a method based on high-performance liquid chromatography (HPLC) coupled to second-order data modeling with multivariate curve resolution-alternating least-squares (MCR-ALS) for quantification of retinoic acid and its main isomers in plasma in only 5.5 min. The...
Açelya Yilmazer et al.
PloS one, 9(12), e114985-e114985 (2014-12-17)
Gene therapy with human adenovirus type 5 (Ad5) has been extensively explored for the treatment of diseases resistant to traditional therapies. Intravenous administration leads to rapid clearance from blood circulation and high liver accumulation, which restrict the use of Ad-based...
Ru-Yin Tsai et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 114(5), 446-455 (2015-02-05)
Microglia have a crucial role in maintaining neuronal homeostasis in the central nervous system. Immune factors released from microglia have important roles in nociceptive signal transduction. Activation of microglia seems to be a shared mechanism in pathological pain and morphine...
Jianzhong Chen et al.
Lipids, 50(8), 821-836 (2015-07-17)
A series of different types of wax esters (represented by RCOOR') were systematically studied by using electrospray ionization (ESI) collision-induced dissociation tandem mass spectrometry (MS/MS) along with pseudo MS(3) (in-source dissociation combined with MS/MS) on a quadrupole time-of-flight (Q-TOF) mass...
Christopher W McAleer et al.
Biotechnology progress, 31(4), 997-1003 (2015-02-17)
This manuscript describes the development of a culture system whereby mature contracting myotubes were formed from adult rat derived satellite cells. Satellite cells, extracted from the Tibialis Anterior of adult rats, were grown in defined serum-free growth and differentiation media...
Wenfen Zhang et al.
Journal of agricultural and food chemistry, 62(26), 6100-6107 (2014-06-17)
In this paper, a rapid and effective HPLC method, using tetraazacalix[2]arene[2]triazine-modified silica gel (NCSi) as solid-phase extraction (SPE) sorbent, was developed for the purification and determination of trace acrylamide in starchy foodstuffs. The main influence factors of SPE including amount...
Madhusudhan Tarigopula et al.
Cardiovascular research, 107(2), 226-234 (2015-06-06)
Therapeutic approaches to treat familial dilated cardiomyopathy (DCM), which is characterized by depressed sarcomeric tension and susceptibility to Ca(2+)-related arrhythmias, have been generally unsuccessful. Our objective in the present work was to determine the effect of the angiotensin II type...
Jingjing Liu et al.
Chemical research in toxicology, 28(3), 394-400 (2014-10-18)
Carcinogenic formaldehyde is produced by endogenous protein oxidation and various exogenous sources. With formaldehyde being both ubiquitous in the ambient environment and one of the most common reactive carbonyls produced from endogenous metabolism, quantifying formaldehyde exposure is an essential step...
Jorge L Torres-Fuentes et al.
Journal of cellular physiology, 230(12), 3068-3075 (2015-05-20)
The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse with the oocyte plasma membrane, and it occurs only in...
Ming-Jun Tsai et al.
PloS one, 10(7), e0131026-e0131026 (2015-07-15)
Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application. Naringenin-loaded elastic liposomes...
Farida F Khan et al.
Biochemical and biophysical research communications, 451(1), 101-106 (2014-07-30)
The Asx-like (ASXL) family proteins are chromatin factors that play dual roles in transcriptional activation and repression. ASXL2 is highly expressed in the heart and is required for proper heart development and function. Here, we identify a novel ASXL2-binding partner...
Li-Ping Zhu et al.
Microbial cell factories, 14, 105-105 (2015-07-22)
Exotic genes, especially clustered multiple-genes for a complex pathway, are normally integrated into chromosome for heterologous expression. The influences of insertion sites on heterologous expression and allotropic expressions of exotic genes on host remain mostly unclear. We compared the integration...
Shaun Martin et al.
Journal of cellular biochemistry, 116(3), 438-449 (2014-10-23)
Glucose-regulated protein 78 (GRP78) is a stress sensor which interacts with unfolded protein response (UPR) activators in the endoplasmic reticulum (ER). The aim of this study was to test the hypothesis that GRP78 has distinct functional roles in mediating the...
Jing Qin et al.
Biomedical chromatography : BMC, 29(7), 1068-1075 (2014-12-18)
Zhenju antihypertensive compound (ZJAHC) is a combined Chinese-Western medicine formula including clonidine (CLO), hydrochlorothiazide (HCT), rutin, Chrysanthemum indicum extract and pearl powder. Compared with CLO preparations, ZJAHC shows improved activities and decreased adverse effects. It is believed that the side...
Mikaella Vouri et al.
Oncotarget, 6(18), 16183-16197 (2015-05-20)
Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene overactivation. The Axl receptor tyrosine kinase is found overexpressed in GBM and thought to contribute to invasiveness, chemoresistance and poor survival. Here, we have evaluated...
Bin Ji et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 107-113 (2015-08-12)
A simple and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of cinnamaldehyde, cinnamic acid, and 2-methoxy cinnamic acid in rat whole blood. It was the first time to study the pharmacokinetics of...
Carla Martin et al.
Immunologic research, 63(1-3), 131-143 (2015-09-24)
An evolving premise is that cytoprotective autophagy responses are essential to monocyte-macrophage differentiation. Whether autophagy functions similarly during the monocyte-to-dendritic cell (DC) transition is unclear. IL-10, which induces apoptosis in maturing human DCs, has been shown to inhibit starvation-induced autophagy...
Stephen W C Chung et al.
Journal of agricultural and food chemistry, 62(25), 5805-5811 (2014-06-06)
This paper reports the development of a method for the quantitative analysis of perfluorinated compounds (PFCs), including C6-C14 perfluorinated carboxylic acids (PFCAs) and C4-C12 perfluorinated sulfonates (PFSAs), in fish and fatty foods by ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)...
Giada Pietrosi et al.
Cell transplantation, 24(8), 1627-1638 (2014-06-28)
Fetal hepatocytes have a high regenerative capacity. The aim of the study was to assess treatment safety and clinical efficacy of human fetal liver cell transplantation through splenic artery infusion. Patients with end-stage chronic liver disease on the waiting list...
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