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Vincent Cattoir et al.
Antimicrobial agents and chemotherapy, 52(8), 2929-2932 (2008-06-04)
A novel QnrB-like plasmid-mediated resistance determinant, QnrB19, was identified from an Escherichia coli clinical isolate from Colombia. Its gene was associated with an ISEcp1-like insertion element that did not act as a promoter for its expression. Using an in vitro
Myriam Arriaga-Alba et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 228-234 (2012-12-04)
The aim of this work is to evaluate vitamins B antimutagenic effect against alkylatings methyl-N-nitro-N-nitrosoguanidine (MNNG), ethyl-N-nitro-N'- nitrosoguanidine (ENNG), frameshift mutagens 2-aminoanthracene (2AA) and 2-acetyl-amino-fluorene (2AF) and ROS-generating antibiotics norfloxacin (NOR) and nalidixic acid (NLX), using the in vitro Ames
Marianne Gunell et al.
Antimicrobial agents and chemotherapy, 53(9), 3832-3836 (2009-07-15)
Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC
Yu Bin Ho et al.
The Science of the total environment, 488-489, 261-267 (2014-05-20)
Repeated applications of animal manure as fertilizer are normal agricultural practices that may release veterinary antibiotics and hormones into the environment from treated animals. Broiler manure samples and their respective manure-amended agricultural soil samples were collected in selected locations in
Yoshikazu Asahina et al.
Journal of medicinal chemistry, 48(9), 3443-3446 (2005-04-29)
Novel 1-trifluoromethyl-4-quinolone derivatives (8a,b) were synthesized, and the antibacterial activity of each was evaluated. An oxidative desulfurization-fluorination reaction was employed to introduce a trifluoromethyl group at the N-1 position as a key step. Among the derivatives, 8a was found to
Jürgen A Bohnert et al.
Antimicrobial agents and chemotherapy, 54(9), 3770-3775 (2010-07-08)
AcrAB-TolC is the major constitutively expressed efflux pump system that provides resistance to a variety of antimicrobial agents and dyes in Escherichia coli. However, no systematically optimized real-time dye efflux assay has been published for the measurement of its activity
Sandra Aedo et al.
Antimicrobial agents and chemotherapy, 56(11), 5458-5464 (2012-08-08)
DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradient centrifugation to separate unbound from
Victor Kuete et al.
Antimicrobial agents and chemotherapy, 54(5), 1749-1752 (2010-02-18)
The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated. The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were
Milagrosa Montes et al.
Antimicrobial agents and chemotherapy, 54(1), 93-97 (2009-10-07)
The aim of this study was to determine the prevalence and characteristics of non-fluoroquinolone (FQ)-susceptible Streptococcus pyogenes isolates and to study their mechanisms of resistance. We performed a prospective prevalence study with 468 isolates collected from 2005 to 2007 and
Dae-Wi Kim et al.
Applied and environmental microbiology, 79(1), 314-321 (2012-10-30)
Microbacterium sp. 4N2-2, isolated from a wastewater treatment plant, converts the antibacterial fluoroquinolone norfloxacin to N-acetylnorfloxacin and three other metabolites. Because N-acetylation results in loss of antibacterial activity, identification of the enzyme responsible is important for understanding fluoroquinolone resistance. The
Ying-Jun Zhou et al.
FEMS microbiology letters, 355(2), 124-130 (2014-05-13)
The antimicrobial activity of one 3-hydroxypyridin-4-one (HPO) hexadentate (1) and three HPO hexadentate-based dendrimeric chelators (2-4) was evaluated. They were found to exhibit marked inhibitory effect on the growth of two Gram-positive bacteria and two Gram-negative bacteria. The combination treatment
Norfloxacin, ciprofloxacin, and ofloxacin: current clinical roles.
D C Hooper et al.
Current clinical topics in infectious diseases, 10, 194-240 (1989-01-01)
Hervé Nicoloff et al.
Antimicrobial agents and chemotherapy, 51(4), 1293-1303 (2007-01-16)
Thirteen spontaneous multiple-antibiotic-resistant (Mar) mutants of Escherichia coli AG100 were isolated on Luria-Bertani (LB) agar in the presence of tetracycline (4 microg/ml). The phenotype was linked to insertion sequence (IS) insertions in marR or acrR or unstable large tandem genomic
Guyue Cheng et al.
Analytical and bioanalytical chemistry, 406(30), 7899-7910 (2014-10-31)
Fluoroquinolones (FQNs) are broad-spectrum antibacterial agents widely used in animal husbandry and aquaculture. The residues and antimicrobial resistance of such antibiotics are a major public health concern. To realize multianalyte detection of FQN residues, a genetically modified bacterium, Escherichia coli
Zhe Meng et al.
Food chemistry, 174, 597-605 (2014-12-23)
A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)
Lauren Becnel Boyd et al.
Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)
Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)
Matthew G Blango et al.
Antimicrobial agents and chemotherapy, 54(5), 1855-1863 (2010-03-17)
Numerous antibiotics have proven to be effective at ameliorating the clinical symptoms of urinary tract infections (UTIs), but recurrent and chronic infections continue to plague many individuals. Most UTIs are caused by strains of uropathogenic Escherichia coli (UPEC), which can
Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates.
Béatrice Berçot et al.
Antimicrobial agents and chemotherapy, 52(12), 4526-4527 (2008-10-08)
Abugafar M L Hossion et al.
Journal of medicinal chemistry, 54(11), 3686-3703 (2011-05-04)
A structure-guided molecular design approach was used to optimize quercetin diacylglycoside analogues that inhibit bacterial DNA gyrase and topoisomerase IV and show potent antibacterial activity against a wide spectrum of relevant pathogens responsible for hospital- and community-acquired infections. In this
Bacterial resistance to norfloxacin and other newer quinolones: pattern and prospects.
D R Nalin
European journal of cancer & clinical oncology, 24 Suppl 1, S55-S61 (1988-01-01)
Jun Okuda et al.
Antimicrobial agents and chemotherapy, 54(11), 4917-4919 (2010-09-02)
A mini-Tn5 insertion into a ciprofloxacin (CIP)-resistant mutant of Vibrio cholerae O1 revealed that overexpression of the vca0421 gene, which encodes a hypothetical protein, in the CIP-resistant mutant carrying a mutation in the quinolone resistance-determining region (QRDR) of the gyrA
C T Lee et al.
Scandinavian journal of infectious diseases. Supplementum, 56, 49-54 (1988-01-01)
In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients. A single oral dose of norfloxacin 800 mg cured 99.2% of 783 patients with penicillinase
Novel variants of the qnrB gene, qnrB22 and qnrB23, in Citrobacter werkmanii and Citrobacter freundii.
Il Kwon Bae et al.
Antimicrobial agents and chemotherapy, 54(7), 3068-3069 (2010-04-28)
Bo Fang et al.
European journal of medicinal chemistry, 45(9), 4388-4398 (2010-07-06)
A series of novel amine-derived bis-azole compounds were designed by the systematical structural modification of Fluconazole and synthesized by a convenient and efficient method, and the antimicrobial activities for all prepared compounds were evaluated in vitro against six representative bacterial
Gemma O'Donnell et al.
Journal of natural products, 72(3), 360-365 (2008-12-20)
From Allium stipitatum, three pyridine-N-oxide alkaloids (1-3) possessing disulfide functional groups were isolated. The structures of these natural products were elucidated by spectroscopic means as 2-(methyldithio)pyridine-N-oxide (1), 2-[(methylthiomethyl)dithio]pyridine-N-oxide (2), and 2,2'-dithio-bis-pyridine-N-oxide (3). The proposed structure of 1 was confirmed by
S M Hasan et al.
European journal of medicinal chemistry, 44(12), 4896-4903 (2009-08-29)
A series of 6-aminomethyl-2-aryl-1-benzopyran-4-one derivatives (10-24) were synthesized. The compounds were tested for anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. Among the tested compounds, six compounds 11, 13, 16, 18, 21 and 23 showed higher degree of anti-inflammatory activity (>75%
Determination of ofloxacin, norfloxacin, and ciprofloxacin in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry.
Lee B-H, et al.
Journal of Chromatography A, 1139(1), 45-52 (2007)
Sabine Renggli et al.
Journal of bacteriology, 195(18), 4067-4073 (2013-07-10)
Bactericidal antibiotics kill by different mechanisms as a result of a specific interaction with their cellular targets. Over the past few years, alternative explanations for cidality have been proposed based on a postulated common pathway, depending on the intracellular production
Markus Fridén et al.
Journal of medicinal chemistry, 52(20), 6233-6243 (2009-09-22)
New experimental methodologies were applied to measure the unbound brain-to-plasma concentration ratio (K(p,uu,brain)) and the unbound CSF-to-plasma concentration ratio (K(p,uu,CSF)) in rats for 43 structurally diverse drugs. The relationship between chemical structure and K(p,uu,brain) was dominated by hydrogen bonding. Contrary
Kenichiro Shimizu et al.
Antimicrobial agents and chemotherapy, 52(10), 3823-3825 (2008-07-23)
A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia
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